GO Annotations Graph

• Symbol: Pcsk5
• Name: proprotein convertase subtilisin/kexin type 5
• ID: MGI:97515

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004175	endopeptidase activity	IDA	J:139345
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004175	endopeptidase activity	IDA	J:136243
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	ISO	J:95653
Molecular Function	GO:0042277	peptide binding	IDA	J:137491
Molecular Function	GO:0004252	serine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004252	serine-type endopeptidase activity	IDA	J:27310
Molecular Function	GO:0004252	serine-type endopeptidase activity	IBA	J:265628
Molecular Function	GO:0008236	serine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0008236	serine-type peptidase activity	IEA	J:72247
Cellular Component	GO:0005788	endoplasmic reticulum lumen	TAS	Reactome:R-MMU-181788
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IDA	J:137491
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005797	Golgi medial cisterna	ISO	J:155856
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:1990635	proximal dendrite	ISO	J:155856
Cellular Component	GO:0005802	trans-Golgi network	ISO	J:155856
Cellular Component	GO:0005802	trans-Golgi network	IBA	J:265628
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:136243
Biological Process	GO:0009952	anterior/posterior pattern specification	ISO	J:164563
Biological Process	GO:0003279	cardiac septum development	IMP	J:222159
Biological Process	GO:0060976	coronary vasculature development	IMP	J:222159
Biological Process	GO:0140447	cytokine precursor processing	IDA	J:136243
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:222159
Biological Process	GO:0007566	embryo implantation	IMP	J:137433
Biological Process	GO:0048566	embryonic digestive tract development	ISO	J:164563
Biological Process	GO:0048566	embryonic digestive tract development	IMP	J:136243
Biological Process	GO:0048706	embryonic skeletal system development	ISO	J:164563
Biological Process	GO:0048706	embryonic skeletal system development	IMP	J:136243
Biological Process	GO:0007565	female pregnancy	IEA	J:60000
Biological Process	GO:0007507	heart development	IMP	J:136243
Biological Process	GO:0001822	kidney development	ISO	J:164563
Biological Process	GO:0001822	kidney development	IMP	J:136243
Biological Process	GO:0035108	limb morphogenesis	IMP	J:136243
Biological Process	GO:0043043	peptide biosynthetic process	IDA	J:136243
Biological Process	GO:0043043	peptide biosynthetic process	ISO	J:164563
Biological Process	GO:0043043	peptide biosynthetic process	IDA	J:27310
Biological Process	GO:0016486	peptide hormone processing	IDA	J:139345
Biological Process	GO:0016486	peptide hormone processing	IDA	J:27310
Biological Process	GO:0016486	peptide hormone processing	IDA	J:136243
Biological Process	GO:0016486	peptide hormone processing	ISO	J:164563
Biological Process	GO:0016486	peptide hormone processing	IBA	J:265628
Biological Process	GO:0033625	positive regulation of integrin activation	ISO	J:155856
Biological Process	GO:2001046	positive regulation of integrin-mediated signaling pathway	ISO	J:155856
Biological Process	GO:1905609	positive regulation of smooth muscle cell-matrix adhesion	ISO	J:155856
Biological Process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0016485	protein processing	IDA	J:27310
Biological Process	GO:0016485	protein processing	IDA	J:136243
Biological Process	GO:0016485	protein processing	ISO	J:164563
Biological Process	GO:0016485	protein processing	IDA	J:139345
Biological Process	GO:0016485	protein processing	IDA	J:169483
Biological Process	GO:0016485	protein processing	ISO	J:95653
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0006508	proteolysis	IEA	J:72247
Biological Process	GO:0030323	respiratory tube development	IMP	J:136243
Biological Process	GO:0006465	signal peptide processing	ISO	J:164563
Biological Process	GO:0019058	viral life cycle	IDA	J:137491