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GO Annotations Graph
Symbol
Name
ID
Furin
furin (paired basic amino acid cleaving enzyme)
MGI:97513

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0004175endopeptidase activityISOJ:164563
Molecular FunctionGO:0016787hydrolase activityIEAJ:60000
Molecular FunctionGO:0046872metal ion bindingIEAJ:60000
Molecular FunctionGO:0048406nerve growth factor bindingISOJ:164563
Molecular FunctionGO:0008233peptidase activityISOJ:164563
Molecular FunctionGO:0008233peptidase activityISOJ:95653
Molecular FunctionGO:0008233peptidase activityISOJ:90197
Molecular FunctionGO:0042277peptide bindingISOJ:164563
Molecular FunctionGO:0002020protease bindingISOJ:164563
Molecular FunctionGO:0005515protein bindingIPIJ:51716
Molecular FunctionGO:0004252serine-type endopeptidase activityISOJ:164563
Molecular FunctionGO:0004252serine-type endopeptidase activityIBAJ:161428
Molecular FunctionGO:0004252serine-type endopeptidase activityISOJ:155856
Molecular FunctionGO:0004867serine-type endopeptidase inhibitor activityISOJ:164563
Molecular FunctionGO:0008236serine-type peptidase activityIEAJ:60000
Cellular ComponentGO:0009986cell surfaceISOJ:164563
Cellular ComponentGO:0005769early endosomeTASJ:79598
Cellular ComponentGO:0005783endoplasmic reticulumISOJ:164563
Cellular ComponentGO:0005789endoplasmic reticulum membraneISOJ:155856
Cellular ComponentGO:0070062extracellular exosomeISOJ:164563
Cellular ComponentGO:0005615extracellular spaceIBAJ:161428
Cellular ComponentGO:0005794Golgi apparatusIEAJ:60000
Cellular ComponentGO:0031985Golgi cisternaISOJ:155856
Cellular ComponentGO:0016021integral component of membraneTASJ:79598
Cellular ComponentGO:0016020membraneISOJ:164563
Cellular ComponentGO:0045121membrane raftISOJ:164563
Cellular ComponentGO:0005886plasma membraneISOJ:155856
Cellular ComponentGO:0005802trans-Golgi networkISOJ:164563
Cellular ComponentGO:0030140trans-Golgi network transport vesicleISOJ:89488
Cellular ComponentGO:0012510trans-Golgi network transport vesicle membraneTASJ:79598
Biological ProcessGO:0008283cell proliferationISOJ:164563
Biological ProcessGO:0010951negative regulation of endopeptidase activityISOJ:164563
Biological ProcessGO:0032804negative regulation of low-density lipoprotein particle receptor catabolic processISOJ:164563
Biological ProcessGO:0032911negative regulation of transforming growth factor beta1 productionISOJ:164563
Biological ProcessGO:0032902nerve growth factor productionISOJ:164563
Biological ProcessGO:0043043peptide biosynthetic processISOJ:164563
Biological ProcessGO:0016486peptide hormone processingISOJ:164563
Biological ProcessGO:0030335positive regulation of cell migrationISOJ:155856
Biological ProcessGO:0030511positive regulation of transforming growth factor beta receptor signaling pathwayISOJ:155856
Biological ProcessGO:0016485protein processingIMPJ:203527
Biological ProcessGO:0016485protein processingIDAJ:163721
Biological ProcessGO:0016485protein processingIMPJ:169483
Biological ProcessGO:0016485protein processingISOJ:164563
Biological ProcessGO:0016485protein processingISOJ:155856
Biological ProcessGO:0016485protein processingISOJ:95653
Biological ProcessGO:0006508proteolysisIEAJ:72247
Biological ProcessGO:0006508proteolysisIEAJ:60000
Biological ProcessGO:0052548regulation of endopeptidase activityISOJ:164563
Biological ProcessGO:0045714regulation of low-density lipoprotein particle receptor biosynthetic processIMPJ:169483
Biological ProcessGO:0042176regulation of protein catabolic processISOJ:164563
Biological ProcessGO:0009966regulation of signal transductionIDAJ:127541
Biological ProcessGO:0032940secretion by cellISOJ:164563
Biological ProcessGO:0006465signal peptide processingISOJ:164563


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory