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GO Annotations Graph
Symbol
Name
ID
Nos3
nitric oxide synthase 3, endothelial cell
MGI:97362

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0003779actin bindingISOJ:155856
Molecular FunctionGO:0003785actin monomer bindingISOJ:164563
Molecular FunctionGO:0034618arginine bindingISOJ:164563
Molecular FunctionGO:0008013beta-catenin bindingISOJ:155856
Molecular FunctionGO:0045296cadherin bindingISOJ:155856
Molecular FunctionGO:0005516calmodulin bindingISOJ:155856
Molecular FunctionGO:0050660flavin adenine dinucleotide bindingIEAJ:72247
Molecular FunctionGO:0010181FMN bindingIEAJ:72247
Molecular FunctionGO:0020037heme bindingISOJ:164563
Molecular FunctionGO:0051879Hsp90 protein bindingISOJ:155856
Molecular FunctionGO:0005506iron ion bindingIEAJ:72247
Molecular FunctionGO:0046872metal ion bindingIEAJ:60000
Molecular FunctionGO:0050661NADP bindingIEAJ:72247
Molecular FunctionGO:0004517nitric-oxide synthase activityISOJ:155856
Molecular FunctionGO:0004517nitric-oxide synthase activityIMPJ:97766
Molecular FunctionGO:0004517nitric-oxide synthase activityISOJ:164563
Molecular FunctionGO:0050998nitric-oxide synthase bindingISOJ:155856
Molecular FunctionGO:0016491oxidoreductase activityIEAJ:60000
Molecular FunctionGO:0016491oxidoreductase activityIEAJ:72247
Molecular FunctionGO:0097110scaffold protein bindingIPIJ:215922
Molecular FunctionGO:0097110scaffold protein bindingISOJ:155856
Molecular FunctionGO:0034617tetrahydrobiopterin bindingISOJ:164563
Cellular ComponentGO:0045177apical part of cellISOJ:155856
Cellular ComponentGO:0005901caveolaISOJ:164563
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0005737cytoplasmISOJ:155856
Cellular ComponentGO:0005737cytoplasmIDAJ:74206
Cellular ComponentGO:0005856cytoskeletonIEAJ:60000
Cellular ComponentGO:0005829cytosolISOJ:155856
Cellular ComponentGO:0005794Golgi apparatusISOJ:155856
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0045121membrane raftISOJ:155856
Cellular ComponentGO:0005739mitochondrionISOJ:155856
Cellular ComponentGO:0005730nucleolusISOJ:155856
Cellular ComponentGO:0005634nucleusISOJ:155856
Cellular ComponentGO:0005634nucleusIDAJ:74206
Cellular ComponentGO:0005886plasma membraneISOJ:155856
Cellular ComponentGO:0042383sarcolemmaISOJ:155856
Cellular ComponentGO:0012506vesicle membraneISOJ:155856
Biological ProcessGO:0001525angiogenesisIMPJ:98913
Biological ProcessGO:0006527arginine catabolic processISOJ:164563
Biological ProcessGO:0001974blood vessel remodelingIMPJ:119620
Biological ProcessGO:0071260cellular response to mechanical stimulusISOJ:155856
Biological ProcessGO:0071560cellular response to transforming growth factor beta stimulusISOJ:155856
Biological ProcessGO:0043542endothelial cell migrationISOJ:164563
Biological ProcessGO:0001701in utero embryonic developmentIMPJ:74206
Biological ProcessGO:0031663lipopolysaccharide-mediated signaling pathwayIMPJ:97766
Biological ProcessGO:0030324lung developmentIMPJ:98913
Biological ProcessGO:0045776negative regulation of blood pressureIBAJ:161428
Biological ProcessGO:0051926negative regulation of calcium ion transportIMPJ:113533
Biological ProcessGO:0008285negative regulation of cell proliferationIMPJ:119620
Biological ProcessGO:0051346negative regulation of hydrolase activityIMPJ:113533
Biological ProcessGO:0014740negative regulation of muscle hyperplasiaIMPJ:119620
Biological ProcessGO:0043267negative regulation of potassium ion transportIMPJ:113533
Biological ProcessGO:0048662negative regulation of smooth muscle cell proliferationISOJ:155856
Biological ProcessGO:0006809nitric oxide biosynthetic processISOJ:155856
Biological ProcessGO:0006809nitric oxide biosynthetic processISOJ:164563
Biological ProcessGO:0006809nitric oxide biosynthetic processIMPJ:97766
Biological ProcessGO:0007263nitric oxide mediated signal transductionIBAJ:161428
Biological ProcessGO:0001542ovulation from ovarian follicleIMPJ:73964
Biological ProcessGO:0055114oxidation-reduction processIEAJ:72247
Biological ProcessGO:0055114oxidation-reduction processIEAJ:60000
Biological ProcessGO:0045766positive regulation of angiogenesisIMPJ:139343
Biological ProcessGO:0043065positive regulation of apoptotic processISOJ:155856
Biological ProcessGO:0031284positive regulation of guanylate cyclase activityIBAJ:161428
Biological ProcessGO:0031284positive regulation of guanylate cyclase activityISOJ:164563
Biological ProcessGO:0045909positive regulation of vasodilationIBAJ:161428
Biological ProcessGO:0050880regulation of blood vessel sizeIMPJ:119620
Biological ProcessGO:0002028regulation of sodium ion transportIMPJ:113533
Biological ProcessGO:0003100regulation of systemic arterial blood pressure by endothelinISOJ:164563
Biological ProcessGO:0003057regulation of the force of heart contraction by chemical signalIGIJ:144878
Biological ProcessGO:0019430removal of superoxide radicalsISOJ:164563
Biological ProcessGO:0032355response to estradiolISOJ:155856
Biological ProcessGO:0007165signal transductionISOJ:155856
Biological ProcessGO:0014806smooth muscle hyperplasiaIMPJ:119620


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory