GO Annotations Graph

• Symbol: Nefh
• Name: neurofilament, heavy polypeptide
• ID: MGI:97309

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:155856
Molecular Function	GO:0005200	structural constituent of cytoskeleton	ISO	J:155856
Molecular Function	GO:0005200	structural constituent of cytoskeleton	ISO	J:164563
Molecular Function	GO:0099184	structural constituent of postsynaptic intermediate filament cytoskeleton	IBA	J:265628
Molecular Function	GO:0099184	structural constituent of postsynaptic intermediate filament cytoskeleton	IMP	J:263470
Molecular Function	GO:0099184	structural constituent of postsynaptic intermediate filament cytoskeleton	IDA	J:263470
Molecular Function	GO:0015643	toxic substance binding	ISO	J:155856
Cellular Component	GO:0097440	apical dendrite	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0030424	axon	ISO	J:168713
Cellular Component	GO:0030424	axon	IDA	J:76723
Cellular Component	GO:0150017	basal proximal dendrite	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005856	cytoskeleton	ISO	J:164563
Cellular Component	GO:0005882	intermediate filament	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0097418	neurofibrillary tangle	ISO	J:164563
Cellular Component	GO:0005883	neurofilament	IBA	J:265628
Cellular Component	GO:0005883	neurofilament	IDA	J:91243
Cellular Component	GO:0005883	neurofilament	IDA	J:158711
Cellular Component	GO:0005883	neurofilament	IDA	J:54791
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IDA	J:187362
Cellular Component	GO:0099160	postsynaptic intermediate filament cytoskeleton	IDA	J:263470
Cellular Component	GO:0099160	postsynaptic intermediate filament cytoskeleton	IDA	J:263470
Cellular Component	GO:0099160	postsynaptic intermediate filament cytoskeleton	IDA	J:263470
Cellular Component	GO:0099160	postsynaptic intermediate filament cytoskeleton	IDA	J:263470
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:263470
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:263470
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:263470
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:263470
Biological Process	GO:0061564	axon development	IMP	J:78119
Biological Process	GO:0061564	axon development	ISO	J:164563
Biological Process	GO:0061564	axon development	IBA	J:265628
Biological Process	GO:0031103	axon regeneration	ISO	J:155856
Biological Process	GO:0007420	brain development	ISO	J:155856
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0045110	intermediate filament bundle assembly	ISO	J:155856
Biological Process	GO:0045110	intermediate filament bundle assembly	IGI	J:56931
Biological Process	GO:0045110	intermediate filament bundle assembly	IGI	J:56931
Biological Process	GO:0045104	intermediate filament cytoskeleton organization	IMP	J:86249
Biological Process	GO:0000226	microtubule cytoskeleton organization	IGI	J:56931
Biological Process	GO:0033693	neurofilament bundle assembly	ISO	J:164563
Biological Process	GO:0060052	neurofilament cytoskeleton organization	IMP	J:165204
Biological Process	GO:0060052	neurofilament cytoskeleton organization	IGI	J:56931
Biological Process	GO:0060052	neurofilament cytoskeleton organization	IGI	J:56931
Biological Process	GO:0001552	ovarian follicle atresia	ISO	J:155856
Biological Process	GO:0048936	peripheral nervous system neuron axonogenesis	IMP	J:165204
Biological Process	GO:0048936	peripheral nervous system neuron axonogenesis	IMP	J:165204
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IDA	J:263470
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IMP	J:263470
Biological Process	GO:1902513	regulation of organelle transport along microtubule	ISO	J:164563
Biological Process	GO:1903935	response to sodium arsenite	ISO	J:155856