Tlr4 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Tlr4
toll-like receptor 4
MGI:96824

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0001530	lipopolysaccharide binding	ISO	J:155856
Molecular Function	GO:0001530	lipopolysaccharide binding	ISO	J:164563
Molecular Function	GO:0001530	lipopolysaccharide binding	IBA	J:265628
Molecular Function	GO:0001875	lipopolysaccharide immune receptor activity	IDA	J:244275
Molecular Function	GO:0001875	lipopolysaccharide immune receptor activity	ISO	J:164563
Molecular Function	GO:0001875	lipopolysaccharide immune receptor activity	IBA	J:265628
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:224712
Molecular Function	GO:0005515	protein binding	IPI	J:195394
Molecular Function	GO:0005515	protein binding	IPI	J:245260
Molecular Function	GO:0005515	protein binding	IPI	J:188561
Molecular Function	GO:0005515	protein binding	IPI	J:138824
Molecular Function	GO:0005515	protein binding	IPI	J:224870
Molecular Function	GO:0005515	protein binding	IPI	J:244275
Molecular Function	GO:0005515	protein binding	IPI	J:127195
Molecular Function	GO:0005515	protein binding	IPI	J:266414
Molecular Function	GO:0005515	protein binding	IPI	J:217935
Molecular Function	GO:0005515	protein binding	IPI	J:184807
Molecular Function	GO:0005515	protein binding	IPI	J:145634
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0038023	signaling receptor activity	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IEA	J:72247
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0046696	lipopolysaccharide receptor complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0001891	phagocytic cup	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:266466
Cellular Component	GO:0005886	plasma membrane	IDA	J:231509
Cellular Component	GO:0043235	receptor complex	IDA	J:244275
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Biological Process	GO:0002218	activation of innate immune response	IMP	J:96405
Biological Process	GO:0007250	activation of NF-kappaB-inducing kinase activity	NAS	J:114045
Biological Process	GO:0014002	astrocyte development	IMP	J:188377
Biological Process	GO:0042100	B cell proliferation	IMP	J:76115
Biological Process	GO:0002322	B cell proliferation involved in immune response	IMP	J:63145
Biological Process	GO:1904646	cellular response to amyloid-beta	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:266466
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:156686
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:191553
Biological Process	GO:0071222	cellular response to lipopolysaccharide	TAS	J:286766
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:87393
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:63145
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:63145
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:215205
Biological Process	GO:0071223	cellular response to lipoteichoic acid	IMP	J:76115
Biological Process	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	ISO	J:164563
Biological Process	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	IGI	J:158401
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	IMP	J:191553
Biological Process	GO:0071346	cellular response to type II interferon	ISO	J:164563
Biological Process	GO:0042742	defense response to bacterium	ISO	J:164563
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IBA	J:265628
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IMP	J:96405
Biological Process	GO:0032497	detection of lipopolysaccharide	IDA	J:244275
Biological Process	GO:0032497	detection of lipopolysaccharide	ISO	J:164563
Biological Process	GO:0032497	detection of lipopolysaccharide	TAS	J:161025
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	ISO	J:155856
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	ISO	J:155856
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IDA	J:132126
Biological Process	GO:0010467	gene expression	IMP	J:136381
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IDA	J:132126
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IDA	J:102721
Biological Process	GO:0007252	I-kappaB phosphorylation	ISO	J:164563
Biological Process	GO:0007252	I-kappaB phosphorylation	IMP	J:145634
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IMP	J:191553
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0006954	inflammatory response	IMP	J:136381
Biological Process	GO:0045087	innate immune response	TAS	J:161025
Biological Process	GO:0002758	innate immune response-activating signaling pathway	ISO	J:155856
Biological Process	GO:0032608	interferon-beta production	IMP	J:96405
Biological Process	GO:0032613	interleukin-10 production	IDA	J:173330
Biological Process	GO:0032635	interleukin-6 production	IMP	J:76115
Biological Process	GO:0032635	interleukin-6 production	IDA	J:132126
Biological Process	GO:0060729	intestinal epithelial structure maintenance	IMP	J:156686
Biological Process	GO:0007254	JNK cascade	IGI	J:102721
Biological Process	GO:0007254	JNK cascade	IDA	J:132126
Biological Process	GO:0007254	JNK cascade	IDA	J:102721
Biological Process	GO:0006691	leukotriene metabolic process	ISO	J:155856
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IDA	J:244275
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IGI	J:63145
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	ISO	J:63145
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IGI	J:63145
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IGI	J:63145
Biological Process	GO:0046651	lymphocyte proliferation	IMP	J:110454
Biological Process	GO:0042116	macrophage activation	ISO	J:164563
Biological Process	GO:0042116	macrophage activation	ISS	J:113899
Biological Process	GO:0042116	macrophage activation	TAS	J:286766
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:76115
Biological Process	GO:0010934	macrophage cytokine production	IDA	J:132126
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:59296
Biological Process	GO:0010934	macrophage cytokine production	IDA	J:173330
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:110454
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:87393
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:96405
Biological Process	GO:0045576	mast cell activation	NAS	J:114045
Biological Process	GO:0045576	mast cell activation	NAS	J:114018
Biological Process	GO:0045342	MHC class II biosynthetic process	IMP	J:76115
Biological Process	GO:0014004	microglia differentiation	IMP	J:136381
Biological Process	GO:0001774	microglial cell activation	ISO	J:155856
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	ISO	J:164563
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	IGI	J:158401
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	IMP	J:249899
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IMP	J:156686
Biological Process	GO:0032700	negative regulation of interleukin-17 production	IMP	J:131398
Biological Process	GO:0032700	negative regulation of interleukin-17 production	IMP	J:156686
Biological Process	GO:0032707	negative regulation of interleukin-23 production	IMP	J:131398
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IMP	J:156686
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IMP	J:131398
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IMP	J:156686
Biological Process	GO:0032689	negative regulation of type II interferon production	IMP	J:156686
Biological Process	GO:0022008	neurogenesis	IMP	J:136381
Biological Process	GO:0006809	nitric oxide biosynthetic process	IMP	J:76115
Biological Process	GO:0002537	nitric oxide production involved in inflammatory response	IMP	J:59296
Biological Process	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway	IDA	J:132126
Biological Process	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA	J:132126
Biological Process	GO:0006909	phagocytosis	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0030890	positive regulation of B cell proliferation	IMP	J:76115
Biological Process	GO:1903974	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	ISO	J:164563
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	ISO	J:164563
Biological Process	GO:0032722	positive regulation of chemokine production	ISO	J:164563
Biological Process	GO:0032722	positive regulation of chemokine production	IDA	J:161025
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	IGI	J:158401
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	ISO	J:164563
Biological Process	GO:0043388	positive regulation of DNA binding	ISO	J:155856
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:132126
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:158401
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:158401
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:158401
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:158401
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:191553
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:191553
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	J:152781
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	J:132126
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	J:102721
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:155856
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0050729	positive regulation of inflammatory response	IGI	J:158401
Biological Process	GO:0032727	positive regulation of interferon-alpha production	IDA	J:161025
Biological Process	GO:0032728	positive regulation of interferon-beta production	IDA	J:161025
Biological Process	GO:0032728	positive regulation of interferon-beta production	IMP	J:96405
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:205721
Biological Process	GO:0032732	positive regulation of interleukin-1 production	IDA	J:161025
Biological Process	GO:0032732	positive regulation of interleukin-1 production	NAS	J:114045
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IDA	J:161025
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IDA	J:173330
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IDA	J:244275
Biological Process	GO:0032735	positive regulation of interleukin-12 production	ISO	J:164563
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IDA	J:161025
Biological Process	GO:0032736	positive regulation of interleukin-13 production	NAS	J:114045
Biological Process	GO:0032755	positive regulation of interleukin-6 production	NAS	J:114045
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:161025
Biological Process	GO:0032755	positive regulation of interleukin-6 production	NAS	J:169799
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:244275
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:76115
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:87393
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:132126
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	IGI	J:102721
Biological Process	GO:0046330	positive regulation of JNK cascade	IDA	J:102721
Biological Process	GO:0046330	positive regulation of JNK cascade	IDA	J:132126
Biological Process	GO:0050671	positive regulation of lymphocyte proliferation	IMP	J:110454
Biological Process	GO:0043032	positive regulation of macrophage activation	IGI	J:158401
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:76115
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:110454
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IDA	J:132126
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IDA	J:173330
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:87393
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IDA	J:132126
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:76115
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:76115
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:96405
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:59296
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IMP	J:156686
Biological Process	GO:1904466	positive regulation of matrix metallopeptidase secretion	ISO	J:164563
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	IMP	J:76115
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:155856
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:298909
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:73065
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	IGI	J:158401
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	IMP	J:76115
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	IDA	J:161025
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	IDA	J:205721
Biological Process	GO:0070430	positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	IDA	J:132126
Biological Process	GO:0070434	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA	J:132126
Biological Process	GO:1903223	positive regulation of oxidative stress-induced neuron death	IGI	J:158401
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0010572	positive regulation of platelet activation	IMP	J:146708
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	IMP	J:158401
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	IMP	J:191553
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	IMP	J:191553
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	IMP	J:191553
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	IMP	J:191553
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	IMP	J:191553
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	IDA	J:132126
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:161025
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IDA	J:161025
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:59296
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IDA	J:132126
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:76115
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:87393
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:110454
Biological Process	GO:0032729	positive regulation of type II interferon production	IMP	J:131398
Biological Process	GO:0002730	regulation of dendritic cell cytokine production	IDA	J:143745
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:131398
Biological Process	GO:0051930	regulation of sensory perception of pain	ISO	J:155856
Biological Process	GO:0032680	regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:0009617	response to bacterium	IMP	J:103167
Biological Process	GO:0045471	response to ethanol	ISO	J:155856
Biological Process	GO:0070542	response to fatty acid	ISO	J:155856
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:155856
Biological Process	GO:0032496	response to lipopolysaccharide	IGI	J:70821
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:76115
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:54987
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:123792
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:73065
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:54987
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:110454
Biological Process	GO:0006979	response to oxidative stress	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0051403	stress-activated MAPK cascade	IDA	J:132126
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	IDA	J:244275
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	ISO	J:164563
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	IDA	J:231509
Biological Process	GO:0002224	toll-like receptor signaling pathway	ISO	J:155856
Biological Process	GO:0002224	toll-like receptor signaling pathway	ISO	J:164563
Biological Process	GO:0002224	toll-like receptor signaling pathway	IBA	J:265628
Biological Process	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	IGI	J:158401
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:76115
Biological Process	GO:0032640	tumor necrosis factor production	IDA	J:132126
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:59296
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:87393
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:59296
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:110454
Biological Process	GO:0032609	type II interferon production	IGI	J:70821
Biological Process	GO:0002246	wound healing involved in inflammatory response	IMP	J:191553

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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