GO Annotations Graph

• Symbol: Ldha
• Name: lactate dehydrogenase A
• ID: MGI:96759

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003824	catalytic activity	IEA	J:72247
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0019900	kinase binding	ISO	J:155856
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	ISO	J:155856
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	ISO	J:164563
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	IBA	J:265628
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	IMP	J:22177
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	IMP	J:14326
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	IDA	J:166607
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	IDA	J:6674
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	IMP	J:15477
Molecular Function	GO:0004457	lactate dehydrogenase activity	ISO	J:155856
Molecular Function	GO:0004457	lactate dehydrogenase activity	IMP	J:14326
Molecular Function	GO:0004457	lactate dehydrogenase activity	IMP	J:14326
Molecular Function	GO:0004457	lactate dehydrogenase activity	IMP	J:14326
Molecular Function	GO:0051287	NAD binding	ISO	J:155856
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:116259
Cellular Component	GO:0005737	cytoplasm	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IDA	J:166357
Cellular Component	GO:0005829	cytosol	IDA	J:76215
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:1990204	oxidoreductase complex	ISO	J:164563
Cellular Component	GO:0035686	sperm fibrous sheath	IDA	J:111771
Biological Process	GO:0019752	carboxylic acid metabolic process	IEA	J:72247
Biological Process	GO:0031668	cellular response to extracellular stimulus	IDA	J:54434
Biological Process	GO:0019661	glucose catabolic process to lactate via pyruvate	IMP	J:14326
Biological Process	GO:0019244	lactate biosynthetic process from pyruvate	IC	J:6674
Biological Process	GO:0006089	lactate metabolic process	ISO	J:164563
Biological Process	GO:0006089	lactate metabolic process	ISO	J:155856
Biological Process	GO:0006089	lactate metabolic process	IBA	J:265628
Biological Process	GO:0019674	NAD metabolic process	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0042867	pyruvate catabolic process	IDA	J:166607
Biological Process	GO:0042867	pyruvate catabolic process	IMP	J:14326
Biological Process	GO:0006090	pyruvate metabolic process	ISO	J:164563
Biological Process	GO:0006090	pyruvate metabolic process	IBA	J:265628