GO Annotations Graph

• Symbol: Il12a
• Name: interleukin 12a
• ID: MGI:96539

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IDA	J:65439
Molecular Function	GO:0008083	growth factor activity	ISO	J:164563
Molecular Function	GO:0042163	interleukin-12 beta subunit binding	ISO	J:164563
Molecular Function	GO:0042163	interleukin-12 beta subunit binding	IPI	J:91804
Molecular Function	GO:0005143	interleukin-12 receptor binding	IEA	J:72247
Molecular Function	GO:0045513	interleukin-27 binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:167328
Molecular Function	GO:0005515	protein binding	IPI	J:127800
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:164687
Cellular Component	GO:0005737	cytoplasm	IDA	J:73394
Cellular Component	GO:0005788	endoplasmic reticulum lumen	TAS	Reactome:R-MMU-8950489
Cellular Component	GO:0031904	endosome lumen	TAS	Reactome:R-MMU-8950510
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9006466
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:15406
Cellular Component	GO:0005615	extracellular space	IDA	J:91804
Cellular Component	GO:0005796	Golgi lumen	TAS	Reactome:R-MMU-8950489
Cellular Component	GO:0005796	Golgi lumen	TAS	Reactome:R-MMU-8950510
Cellular Component	GO:0043514	interleukin-12 complex	ISO	J:164563
Cellular Component	GO:0043514	interleukin-12 complex	ISO	J:164563
Cellular Component	GO:0043514	interleukin-12 complex	IDA	J:91804
Cellular Component	GO:0043514	interleukin-12 complex	IGI	J:15406
Cellular Component	GO:0042022	interleukin-12 receptor complex	NAS	J:37050
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	IGI	J:98417
Biological Process	GO:0008283	cell population proliferation	IDA	J:98417
Biological Process	GO:0008283	cell population proliferation	IGI	J:98417
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:143745
Biological Process	GO:0098586	cellular response to virus	ISO	J:164563
Biological Process	GO:0042832	defense response to protozoan	IDA	J:142066
Biological Process	GO:0042832	defense response to protozoan	IDA	J:143745
Biological Process	GO:0042832	defense response to protozoan	IGI	J:111178
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0006955	immune response	NAS	J:319975
Biological Process	GO:0035722	interleukin-12-mediated signaling pathway	ISO	J:164563
Biological Process	GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0032700	negative regulation of interleukin-17 production	ISO	J:164563
Biological Process	GO:0050709	negative regulation of protein secretion	ISO	J:164563
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	ISO	J:164563
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:164563
Biological Process	GO:2000510	positive regulation of dendritic cell chemotaxis	ISO	J:164563
Biological Process	GO:0050671	positive regulation of lymphocyte proliferation	ISO	J:164563
Biological Process	GO:0032946	positive regulation of mononuclear cell proliferation	ISO	J:164563
Biological Process	GO:0032816	positive regulation of natural killer cell activation	ISO	J:164563
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	ISO	J:164563
Biological Process	GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	ISO	J:164563
Biological Process	GO:0032819	positive regulation of natural killer cell proliferation	ISO	J:164563
Biological Process	GO:0051135	positive regulation of NK T cell activation	ISO	J:164563
Biological Process	GO:0051142	positive regulation of NK T cell proliferation	ISO	J:164563
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0034393	positive regulation of smooth muscle cell apoptotic process	ISO	J:164563
Biological Process	GO:0045582	positive regulation of T cell differentiation	IGI	J:191418
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	ISO	J:164563
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:0042102	positive regulation of T cell proliferation	IDA	J:65966
Biological Process	GO:0042102	positive regulation of T cell proliferation	IDA	J:65439
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	IGI	J:111178
Biological Process	GO:0032729	positive regulation of type II interferon production	IGI	J:98417
Biological Process	GO:0032729	positive regulation of type II interferon production	IGI	J:98417
Biological Process	GO:0032729	positive regulation of type II interferon production	IDA	J:173261
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0010224	response to UV-B	ISO	J:164563
Biological Process	GO:0042098	T cell proliferation	IDA	J:65439
Biological Process	GO:0035711	T-helper 1 cell activation	IDA	J:189858
Biological Process	GO:0035744	T-helper 1 cell cytokine production	IGI	J:98417
Biological Process	GO:0035744	T-helper 1 cell cytokine production	IGI	J:98417
Biological Process	GO:0032609	type II interferon production	IGI	J:111178
Biological Process	GO:0032609	type II interferon production	IDA	J:173261