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GO Annotations Graph
Symbol
Name
ID
Ide
insulin degrading enzyme
MGI:96412

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005524ATP bindingISOJ:164563
Molecular FunctionGO:0005524ATP bindingISOJ:155856
Molecular FunctionGO:0016887ATPase activityISOJ:155856
Molecular FunctionGO:0001540beta-amyloid bindingISOJ:155856
Molecular FunctionGO:0031626beta-endorphin bindingISOJ:155856
Molecular FunctionGO:0003824catalytic activityIEAJ:72247
Molecular FunctionGO:0003824catalytic activityIEAJ:60000
Molecular FunctionGO:0001948glycoprotein bindingISOJ:164563
Molecular FunctionGO:0016787hydrolase activityIEAJ:60000
Molecular FunctionGO:0043559insulin bindingISOJ:164563
Molecular FunctionGO:0043559insulin bindingISOJ:155856
Molecular FunctionGO:0046872metal ion bindingIEAJ:72247
Molecular FunctionGO:0046872metal ion bindingIEAJ:60000
Molecular FunctionGO:0004222metalloendopeptidase activityIBAJ:161428
Molecular FunctionGO:0004222metalloendopeptidase activityISOJ:155856
Molecular FunctionGO:0004222metalloendopeptidase activityISOJ:164563
Molecular FunctionGO:0008237metallopeptidase activityIEAJ:60000
Molecular FunctionGO:0000166nucleotide bindingIEAJ:60000
Molecular FunctionGO:0008233peptidase activityIEAJ:60000
Molecular FunctionGO:0042277peptide bindingISOJ:164563
Molecular FunctionGO:0017046peptide hormone bindingISOJ:155856
Molecular FunctionGO:0042803protein homodimerization activityISOJ:155856
Molecular FunctionGO:0042803protein homodimerization activityISOJ:164563
Molecular FunctionGO:0005102receptor bindingISOJ:164563
Molecular FunctionGO:0043130ubiquitin bindingISOJ:164563
Molecular FunctionGO:0008270zinc ion bindingIBAJ:161428
Molecular FunctionGO:0008270zinc ion bindingISOJ:155856
Molecular FunctionGO:0008270zinc ion bindingISOJ:164563
Cellular ComponentGO:0009986cell surfaceISOJ:164563
Cellular ComponentGO:0009986cell surfaceISOJ:155856
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0005829cytosolIBAJ:161428
Cellular ComponentGO:0005829cytosolISOJ:155856
Cellular ComponentGO:0005829cytosolISOJ:164563
Cellular ComponentGO:0031597cytosolic proteasome complexISOJ:155856
Cellular ComponentGO:0005576extracellular regionIEAJ:60000
Cellular ComponentGO:0005615extracellular spaceISOJ:155856
Cellular ComponentGO:0005615extracellular spaceISOJ:164563
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0005739mitochondrionISOJ:164563
Cellular ComponentGO:0005739mitochondrionIDAJ:151002
Cellular ComponentGO:0005654nucleoplasmISOJ:164563
Cellular ComponentGO:0005634nucleusISOJ:155856
Cellular ComponentGO:0005782peroxisomal matrixIBAJ:161428
Cellular ComponentGO:0005782peroxisomal matrixISOJ:155856
Cellular ComponentGO:0005777peroxisomeISOJ:164563
Cellular ComponentGO:0005886plasma membraneIEAJ:60000
Biological ProcessGO:0050435beta-amyloid metabolic processISOJ:155856
Biological ProcessGO:0050435beta-amyloid metabolic processISOJ:164563
Biological ProcessGO:0010815bradykinin catabolic processISOJ:164563
Biological ProcessGO:0044257cellular protein catabolic processISOJ:155856
Biological ProcessGO:0008340determination of adult lifespanISOJ:164563
Biological ProcessGO:0042447hormone catabolic processISOJ:155856
Biological ProcessGO:1901143insulin catabolic processISOJ:164563
Biological ProcessGO:1901142insulin metabolic processISOJ:164563
Biological ProcessGO:0008152metabolic processIEAJ:60000
Biological ProcessGO:0045861negative regulation of proteolysisISOJ:155856
Biological ProcessGO:0043171peptide catabolic processIBAJ:161428
Biological ProcessGO:0032461positive regulation of protein oligomerizationISOJ:164563
Biological ProcessGO:0051291protein heterooligomerizationISOJ:155856
Biological ProcessGO:0051260protein homooligomerizationISOJ:164563
Biological ProcessGO:0051289protein homotetramerizationISOJ:155856
Biological ProcessGO:0016485protein processingIBAJ:161428
Biological ProcessGO:0006508proteolysisISOJ:164563
Biological ProcessGO:0051603proteolysis involved in cellular protein catabolic processISOJ:164563
Biological ProcessGO:0051603proteolysis involved in cellular protein catabolic processISOJ:155856
Biological ProcessGO:0051603proteolysis involved in cellular protein catabolic processIBAJ:161428
Biological ProcessGO:0010992ubiquitin homeostasisISOJ:164563


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory