GO Annotations Graph

• Symbol: Grin2b
• Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
• ID: MGI:95821

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:155856
Molecular Function	GO:0005262	calcium channel activity	IMP	J:102147
Molecular Function	GO:0050839	cell adhesion molecule binding	ISO	J:155856
Molecular Function	GO:0031749	D2 dopamine receptor binding	ISO	J:155856
Molecular Function	GO:0005234	extracellularly glutamate-gated ion channel activity	ISO	J:155856
Molecular Function	GO:0016595	glutamate binding	ISO	J:155856
Molecular Function	GO:0022849	glutamate-gated calcium ion channel activity	ISO	J:164563
Molecular Function	GO:0016594	glycine binding	ISO	J:164563
Molecular Function	GO:1901363	heterocyclic compound binding	ISO	J:155856
Molecular Function	GO:0005149	interleukin-1 receptor binding	ISO	J:155856
Molecular Function	GO:0004970	ionotropic glutamate receptor activity	ISO	J:155856
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	ISO	J:155856
Molecular Function	GO:0015276	ligand-gated monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005261	monoatomic cation channel activity	IGI	J:21285
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0042165	neurotransmitter binding	ISO	J:155856
Molecular Function	GO:0099583	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	ISO	J:155856
Molecular Function	GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	IMP	J:152455
Molecular Function	GO:0004972	NMDA glutamate receptor activity	ISO	J:155856
Molecular Function	GO:0004972	NMDA glutamate receptor activity	ISO	J:164563
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IBA	J:265628
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IGI	J:21285
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:45446
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:102147
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:103962
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:84361
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IGI	J:84361
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IGI	J:1333
Molecular Function	GO:0005515	protein binding	IPI	J:249721
Molecular Function	GO:0005515	protein binding	IPI	J:181943
Molecular Function	GO:0005515	protein binding	IPI	J:181943
Molecular Function	GO:0005515	protein binding	IPI	J:304172
Molecular Function	GO:0005515	protein binding	IPI	J:161179
Molecular Function	GO:0005515	protein binding	IPI	J:161179
Molecular Function	GO:0005515	protein binding	IPI	J:119025
Molecular Function	GO:0005515	protein binding	IPI	J:119025
Molecular Function	GO:0005515	protein binding	IPI	J:119798
Molecular Function	GO:0005515	protein binding	IPI	J:144029
Molecular Function	GO:0005515	protein binding	IPI	J:146779
Molecular Function	GO:0005515	protein binding	IPI	J:145953
Molecular Function	GO:0005515	protein binding	IPI	J:227842
Molecular Function	GO:0005515	protein binding	IPI	J:63100
Molecular Function	GO:0005515	protein binding	IPI	J:145953
Molecular Function	GO:0005515	protein binding	IPI	J:63100
Molecular Function	GO:0005515	protein binding	IPI	J:241916
Molecular Function	GO:0005515	protein binding	IPI	J:127744
Molecular Function	GO:0005515	protein binding	IPI	J:145953
Molecular Function	GO:0005515	protein binding	IPI	J:282038
Molecular Function	GO:0005515	protein binding	IPI	J:116426
Molecular Function	GO:0005515	protein binding	IPI	J:208030
Molecular Function	GO:0005515	protein binding	IPI	J:322379
Molecular Function	GO:0005515	protein binding	IPI	J:152628
Molecular Function	GO:0005515	protein binding	IPI	J:37859
Molecular Function	GO:0005515	protein binding	IPI	J:33060
Molecular Function	GO:0005515	protein binding	IPI	J:124046
Molecular Function	GO:0005515	protein binding	IPI	J:298978
Molecular Function	GO:0005515	protein binding	IPI	J:124046
Molecular Function	GO:0005515	protein binding	IPI	J:124046
Molecular Function	GO:0005515	protein binding	IPI	J:106962
Molecular Function	GO:0005515	protein binding	IPI	J:176220
Molecular Function	GO:0005515	protein binding	IPI	J:95556
Molecular Function	GO:0005515	protein binding	IPI	J:98227
Molecular Function	GO:0005515	protein binding	IPI	J:124046
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Molecular Function	GO:0038023	signaling receptor activity	IEA	J:72247
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0036094	small molecule binding	ISO	J:155856
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO	J:155856
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA	J:265628
Molecular Function	GO:0008270	zinc ion binding	ISO	J:155856
Cellular Component	GO:0097440	apical dendrite	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:227842
Cellular Component	GO:0009986	cell surface	IDA	J:128028
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IMP	J:128028
Cellular Component	GO:0009986	cell surface	IDA	J:176220
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0044307	dendritic branch	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0005789	endoplasmic reticulum membrane	TAS	Reactome:R-MMU-9610352
Cellular Component	GO:0005789	endoplasmic reticulum membrane	TAS	Reactome:R-MMU-9610428
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:152455
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:152455
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	ISO	J:155856
Cellular Component	GO:0005770	late endosome	IDA	J:282038
Cellular Component	GO:0005764	lysosome	IDA	J:282038
Cellular Component	GO:0016020	membrane	IDA	J:37859
Cellular Component	GO:0016020	membrane	IDA	J:298978
Cellular Component	GO:0016020	membrane	IDA	J:62660
Cellular Component	GO:0016020	membrane	IDA	J:34361
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	IDA	J:184110
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	ISO	J:155856
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	ISO	J:164563
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	IBA	J:265628
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	IPI	J:37859
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-3928613
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-3928635
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9610641
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0098794	postsynapse	IDA	J:237681
Cellular Component	GO:0098794	postsynapse	IDA	J:298978
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IDA	J:227842
Cellular Component	GO:0014069	postsynaptic density	IDA	J:175650
Cellular Component	GO:0014069	postsynaptic density	IDA	J:260353
Cellular Component	GO:0014069	postsynaptic density	IDA	J:96798
Cellular Component	GO:0014069	postsynaptic density	IDA	J:101558
Cellular Component	GO:0014069	postsynaptic density	IDA	J:176220
Cellular Component	GO:0014069	postsynaptic density	IDA	J:187362
Cellular Component	GO:0014069	postsynaptic density	IDA	J:207532
Cellular Component	GO:0098839	postsynaptic density membrane	ISO	J:155856
Cellular Component	GO:0098839	postsynaptic density membrane	IBA	J:265628
Cellular Component	GO:0098839	postsynaptic density membrane	IDA	J:152455
Cellular Component	GO:0098839	postsynaptic density membrane	IDA	J:152455
Cellular Component	GO:0045211	postsynaptic membrane	NAS	J:92648
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:84686
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:83403
Cellular Component	GO:0048787	presynaptic active zone membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:114728
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	IDA	J:86846
Cellular Component	GO:0045202	synapse	IDA	J:298978
Cellular Component	GO:0045202	synapse	IDA	J:119025
Cellular Component	GO:0043083	synaptic cleft	ISO	J:155856
Cellular Component	GO:0097060	synaptic membrane	IDA	J:227842
Cellular Component	GO:0008021	synaptic vesicle	IDA	J:62660
Cellular Component	GO:0008021	synaptic vesicle	IDA	J:160616
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Cellular Component	GO:0030658	transport vesicle membrane	TAS	Reactome:R-MMU-9610428
Cellular Component	GO:0030658	transport vesicle membrane	TAS	Reactome:R-MMU-9610641
Cellular Component	GO:0030018	Z disc	ISO	J:155856
Biological Process	GO:0001508	action potential	ISO	J:155856
Biological Process	GO:0008306	associative learning	ISO	J:155856
Biological Process	GO:0001662	behavioral fear response	ISO	J:155856
Biological Process	GO:0001662	behavioral fear response	IMP	J:119025
Biological Process	GO:0048266	behavioral response to pain	IMP	J:103722
Biological Process	GO:0097553	calcium ion transmembrane import into cytosol	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	IMP	J:102147
Biological Process	GO:0006816	calcium ion transport	IMP	J:101085
Biological Process	GO:0007268	chemical synaptic transmission	IMP	J:31622
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	IMP	J:101558
Biological Process	GO:0009790	embryo development	IMP	J:45446
Biological Process	GO:0060079	excitatory postsynaptic potential	IBA	J:265628
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:103962
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:114728
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:41902
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:85901
Biological Process	GO:0060079	excitatory postsynaptic potential	IGI	J:86846
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:84361
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:101085
Biological Process	GO:0042596	fear response	IMP	J:114728
Biological Process	GO:0001701	in utero embryonic development	IMP	J:41902
Biological Process	GO:0035235	ionotropic glutamate receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007612	learning	IDA	J:57250
Biological Process	GO:0007612	learning	IMP	J:119025
Biological Process	GO:0007611	learning or memory	ISO	J:155856
Biological Process	GO:0007611	learning or memory	TAS	J:114138
Biological Process	GO:0060291	long-term synaptic potentiation	IBA	J:265628
Biological Process	GO:0060291	long-term synaptic potentiation	IGI	J:163089
Biological Process	GO:0060291	long-term synaptic potentiation	IMP	J:129729
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0007613	memory	IDA	J:57250
Biological Process	GO:0007613	memory	IMP	J:204131
Biological Process	GO:0007613	memory	IMP	J:114728
Biological Process	GO:0006812	monoatomic cation transport	IGI	J:21285
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:1902951	negative regulation of dendritic spine maintenance	IGI	J:190064
Biological Process	GO:0098989	NMDA selective glutamate receptor signaling pathway	ISO	J:155856
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:2001056	positive regulation of cysteine-type endopeptidase activity	ISO	J:155856
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0014049	positive regulation of glutamate secretion	ISO	J:155856
Biological Process	GO:1901216	positive regulation of neuron death	IGI	J:190064
Biological Process	GO:0050806	positive regulation of synaptic transmission	ISO	J:155856
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0051290	protein heterotetramerization	ISO	J:155856
Biological Process	GO:0043113	receptor clustering	ISO	J:155856
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	ISO	J:155856
Biological Process	GO:0043408	regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	NAS	J:88689
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	TAS	J:114138
Biological Process	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0060078	regulation of postsynaptic membrane potential	IMP	J:114728
Biological Process	GO:0010738	regulation of protein kinase A signaling	IMP	J:204131
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:107683
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:119025
Biological Process	GO:0045471	response to ethanol	ISO	J:164563
Biological Process	GO:0045471	response to ethanol	IMP	J:85901
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0010243	response to organonitrogen compound	ISO	J:155856
Biological Process	GO:0048511	rhythmic process	ISO	J:155856
Biological Process	GO:0046960	sensitization	ISO	J:155856
Biological Process	GO:0007423	sensory organ development	IMP	J:31622
Biological Process	GO:0001964	startle response	IMP	J:89405
Biological Process	GO:0001964	startle response	IGI	J:101619
Biological Process	GO:0001967	suckling behavior	IMP	J:31622
Biological Process	GO:0035249	synaptic transmission, glutamatergic	IBA	J:265628