GO Annotations Graph

• Symbol: Gcg
• Name: glucagon
• ID: MGI:95674

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031767	gastric inhibitory polypeptide receptor binding	ISO	J:164563
Molecular Function	GO:0031769	glucagon receptor binding	ISO	J:155856
Molecular Function	GO:0031769	glucagon receptor binding	IBA	J:265628
Molecular Function	GO:0005179	hormone activity	ISO	J:155856
Molecular Function	GO:0005179	hormone activity	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:270934
Cellular Component	GO:0005737	cytoplasm	IDA	J:160042
Cellular Component	GO:0005737	cytoplasm	IDA	J:168575
Cellular Component	GO:0005737	cytoplasm	IDA	J:127471
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IDA	J:179825
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:126780
Cellular Component	GO:0005886	plasma membrane	IDA	J:270934
Cellular Component	GO:0034774	secretory granule lumen	TAS	Reactome:R-MMU-508205
Cellular Component	GO:0034774	secretory granule lumen	TAS	Reactome:R-MMU-508217
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	J:160042
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0071377	cellular response to glucagon stimulus	IDA	J:270934
Biological Process	GO:0006094	gluconeogenesis	IDA	J:204007
Biological Process	GO:0042593	glucose homeostasis	IDA	J:179825
Biological Process	GO:0043066	negative regulation of apoptotic process	IDA	J:160042
Biological Process	GO:0043066	negative regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0032099	negative regulation of appetite	ISO	J:155856
Biological Process	GO:1900118	negative regulation of execution phase of apoptosis	IDA	J:160042
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	IDA	J:160042
Biological Process	GO:0090280	positive regulation of calcium ion import	IDA	J:160042
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:160042
Biological Process	GO:0045722	positive regulation of gluconeogenesis	IDA	J:204007
Biological Process	GO:0051571	positive regulation of histone H3-K4 methylation	IGI	J:204007
Biological Process	GO:0051571	positive regulation of histone H3-K4 methylation	IGI	J:204007
Biological Process	GO:0051571	positive regulation of histone H3-K4 methylation	IGI	J:204007
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	IDA	J:160042
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	IBA	J:265628
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IDA	J:160042
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	IDA	J:160042
Biological Process	GO:0032092	positive regulation of protein binding	IDA	J:160042
Biological Process	GO:0045860	positive regulation of protein kinase activity	IDA	J:160042
Biological Process	GO:0010737	protein kinase A signaling	IMP	J:160042
Biological Process	GO:0010737	protein kinase A signaling	IBA	J:265628
Biological Process	GO:0050796	regulation of insulin secretion	IDA	J:179825
Biological Process	GO:0050796	regulation of insulin secretion	IDA	J:89497
Biological Process	GO:0014823	response to activity	IDA	J:179825