GO Annotations Graph

• Symbol: Sfrp1
• Name: secreted frizzled-related protein 1
• ID: MGI:892014

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0005109	frizzled binding	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:147775
Molecular Function	GO:0017147	Wnt-protein binding	ISO	J:164563
Molecular Function	GO:0017147	Wnt-protein binding	IBA	J:265628
Molecular Function	GO:0017147	Wnt-protein binding	ISO	J:121773
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:130925
Biological Process	GO:0030036	actin cytoskeleton organization	ISO	J:130925
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:106551
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:157031
Biological Process	GO:0060346	bone trabecula formation	IMP	J:89547
Biological Process	GO:0060070	canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0060070	canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:157031
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0071391	cellular response to estrogen stimulus	IDA	J:140742
Biological Process	GO:0071391	cellular response to estrogen stimulus	ISO	J:164563
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	ISO	J:164563
Biological Process	GO:0071363	cellular response to growth factor stimulus	ISO	J:164563
Biological Process	GO:0071504	cellular response to heparin	ISO	J:164563
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0071481	cellular response to X-ray	IDA	J:164747
Biological Process	GO:0090246	convergent extension involved in somitogenesis	IGI	J:135313
Biological Process	GO:0090246	convergent extension involved in somitogenesis	IGI	J:135313
Biological Process	GO:0046546	development of primary male sexual characteristics	IGI	J:147206
Biological Process	GO:0048546	digestive tract morphogenesis	IGI	J:147041
Biological Process	GO:0048546	digestive tract morphogenesis	IGI	J:147041
Biological Process	GO:0048546	digestive tract morphogenesis	IGI	J:147041
Biological Process	GO:0071542	dopaminergic neuron differentiation	IDA	J:227463
Biological Process	GO:0009950	dorsal/ventral axis specification	ISO	J:164563
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IMP	J:89547
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IMP	J:89547
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IMP	J:89547
Biological Process	GO:0008585	female gonad development	IGI	J:147206
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	ISO	J:164563
Biological Process	GO:0060218	hematopoietic stem cell differentiation	ISO	J:164563
Biological Process	GO:0030097	hemopoiesis	IMP	J:152080
Biological Process	GO:0008584	male gonad development	IGI	J:147206
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0060766	negative regulation of androgen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0045578	negative regulation of B cell differentiation	IMP	J:140742
Biological Process	GO:0045578	negative regulation of B cell differentiation	ISO	J:164563
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IGI	J:157031
Biological Process	GO:0046851	negative regulation of bone remodeling	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:155856
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:164862
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:121773
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:157031
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:2000080	negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation	ISO	J:164563
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:2000270	negative regulation of fibroblast apoptotic process	ISO	J:164563
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:157031
Biological Process	GO:0046676	negative regulation of insulin secretion	ISO	J:164563
Biological Process	GO:0043508	negative regulation of JUN kinase activity	IGI	J:147041
Biological Process	GO:0043508	negative regulation of JUN kinase activity	IGI	J:147041
Biological Process	GO:0030279	negative regulation of ossification	ISO	J:164563
Biological Process	GO:0030279	negative regulation of ossification	IMP	J:150387
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	IMP	J:89547
Biological Process	GO:0033689	negative regulation of osteoblast proliferation	ISO	J:164563
Biological Process	GO:0033689	negative regulation of osteoblast proliferation	IMP	J:89547
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	ISO	J:155856
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	IMP	J:89547
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation	IGI	J:135313
Biological Process	GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation	IGI	J:135313
Biological Process	GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation	IGI	J:135313
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	ISO	J:155856
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IGI	J:147041
Biological Process	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification	ISO	J:164563
Biological Process	GO:0014034	neural crest cell fate commitment	IMP	J:157931
Biological Process	GO:0001843	neural tube closure	IGI	J:157031
Biological Process	GO:0021915	neural tube development	IGI	J:157031
Biological Process	GO:0035567	non-canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0030316	osteoclast differentiation	IMP	J:89547
Biological Process	GO:0003402	planar cell polarity pathway involved in axis elongation	IGI	J:135313
Biological Process	GO:0003402	planar cell polarity pathway involved in axis elongation	IGI	J:135313
Biological Process	GO:0003402	planar cell polarity pathway involved in axis elongation	IGI	J:135313
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	IGI	J:135313
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	IGI	J:135313
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	IGI	J:135313
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IMP	J:89547
Biological Process	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:0045600	positive regulation of fat cell differentiation	ISO	J:164563
Biological Process	GO:0045600	positive regulation of fat cell differentiation	ISO	J:78619
Biological Process	GO:2000271	positive regulation of fibroblast apoptotic process	ISO	J:164563
Biological Process	GO:2000052	positive regulation of non-canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	ISO	J:164563
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IMP	J:136160
Biological Process	GO:0060687	regulation of branching involved in prostate gland morphogenesis	IMP	J:136160
Biological Process	GO:0010564	regulation of cell cycle process	ISO	J:164563
Biological Process	GO:0090175	regulation of establishment of planar polarity	IGI	J:147041
Biological Process	GO:0090175	regulation of establishment of planar polarity	IGI	J:147041
Biological Process	GO:0090175	regulation of establishment of planar polarity	IGI	J:147041
Biological Process	GO:1904956	regulation of midbrain dopaminergic neuron differentiation	IGI	J:190506
Biological Process	GO:0010975	regulation of neuron projection development	IDA	J:190506
Biological Process	GO:0030278	regulation of ossification	ISO	J:155856
Biological Process	GO:0014070	response to organic cyclic compound	ISO	J:164563
Biological Process	GO:0009410	response to xenobiotic stimulus	IDA	J:164747
Biological Process	GO:0035019	somatic stem cell population maintenance	IMP	J:152080
Biological Process	GO:0001756	somitogenesis	IEP	J:53153
Biological Process	GO:0001756	somitogenesis	IGI	J:106551
Biological Process	GO:0044345	stromal-epithelial cell signaling involved in prostate gland development	IEP	J:164785
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	ISO	J:130925
Biological Process	GO:0001657	ureteric bud development	IEP	J:112220
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000
Biological Process	GO:0090244	Wnt signaling pathway involved in somitogenesis	IGI	J:135313
Biological Process	GO:0090244	Wnt signaling pathway involved in somitogenesis	IGI	J:135313
Biological Process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	IDA	J:136160