GO Annotations Graph

• Symbol: Crh
• Name: corticotropin releasing hormone
• ID: MGI:88496

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0017045	corticotropin-releasing hormone activity	IBA	J:265628
Molecular Function	GO:0051430	corticotropin-releasing hormone receptor 1 binding	ISO	J:155856
Molecular Function	GO:0051431	corticotropin-releasing hormone receptor 2 binding	ISO	J:155856
Molecular Function	GO:0005179	hormone activity	IEA	J:60000
Molecular Function	GO:0005179	hormone activity	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9017984
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	IDA	J:286599
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0043196	varicosity	ISO	J:155856
Biological Process	GO:0030325	adrenal gland development	IMP	J:62908
Biological Process	GO:0008306	associative learning	ISO	J:155856
Biological Process	GO:0071314	cellular response to cocaine	ISO	J:155856
Biological Process	GO:0007565	female pregnancy	ISO	J:164563
Biological Process	GO:0006704	glucocorticoid biosynthetic process	IMP	J:62908
Biological Process	GO:0008628	hormone-mediated apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:0006954	inflammatory response	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	IMP	J:90690
Biological Process	GO:0007611	learning or memory	ISO	J:155856
Biological Process	GO:0035641	locomotory exploration behavior	IGI	J:147475
Biological Process	GO:0060291	long-term synaptic potentiation	ISO	J:155856
Biological Process	GO:0030324	lung development	IMP	J:62908
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:155856
Biological Process	GO:0032811	negative regulation of epinephrine secretion	ISO	J:155856
Biological Process	GO:0032811	negative regulation of epinephrine secretion	IBA	J:265628
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0070093	negative regulation of glucagon secretion	ISO	J:155856
Biological Process	GO:0070093	negative regulation of glucagon secretion	IBA	J:265628
Biological Process	GO:0033685	negative regulation of luteinizing hormone secretion	ISO	J:155856
Biological Process	GO:0010700	negative regulation of norepinephrine secretion	ISO	J:155856
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	ISO	J:155856
Biological Process	GO:2000987	positive regulation of behavioral fear response	ISO	J:155856
Biological Process	GO:0090280	positive regulation of calcium ion import	ISO	J:155856
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	ISO	J:155856
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:2000854	positive regulation of corticosterone secretion	ISO	J:155856
Biological Process	GO:0051461	positive regulation of corticotropin secretion	ISO	J:164563
Biological Process	GO:0051461	positive regulation of corticotropin secretion	ISO	J:155856
Biological Process	GO:0051464	positive regulation of cortisol secretion	ISO	J:164563
Biological Process	GO:0051464	positive regulation of cortisol secretion	IBA	J:265628
Biological Process	GO:0060456	positive regulation of digestive system process	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:2000310	regulation of NMDA receptor activity	ISO	J:164563
Biological Process	GO:2000310	regulation of NMDA receptor activity	ISO	J:155856
Biological Process	GO:0014062	regulation of serotonin secretion	ISO	J:155856
Biological Process	GO:0001963	synaptic transmission, dopaminergic	ISO	J:155856
Biological Process	GO:0001963	synaptic transmission, dopaminergic	ISO	J:164563