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GO Annotations Graph
Symbol
Name
ID
Cftr
cystic fibrosis transmembrane conductance regulator
MGI:88388

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005524ATP bindingIEAJ:60000
Molecular FunctionGO:0005524ATP bindingIEAJ:72247
Molecular FunctionGO:0016887ATPase activityIEAJ:72247
Molecular FunctionGO:0042626ATPase activity, coupled to transmembrane movement of substancesIEAJ:72247
Molecular FunctionGO:0015106bicarbonate transmembrane transporter activityIMPJ:185780
Molecular FunctionGO:0005260channel-conductance-controlling ATPase activityIEAJ:72245
Molecular FunctionGO:0005254chloride channel activityIMPJ:221546
Molecular FunctionGO:0005254chloride channel activityISOJ:164563
Molecular FunctionGO:0019869chloride channel inhibitor activityISOJ:164563
Molecular FunctionGO:0015108chloride transmembrane transporter activityIMPJ:185780
Molecular FunctionGO:0019899enzyme bindingISOJ:164563
Molecular FunctionGO:0016787hydrolase activityIEAJ:60000
Molecular FunctionGO:0000166nucleotide bindingIEAJ:60000
Molecular FunctionGO:0030165PDZ domain bindingISOJ:164563
Molecular FunctionGO:0005515protein bindingIPIJ:185780
Molecular FunctionGO:0005515protein bindingIPIJ:185780
Molecular FunctionGO:0005515protein bindingIPIJ:185780
Molecular FunctionGO:0005515protein bindingIPIJ:144738
Molecular FunctionGO:0005515protein bindingIPIJ:200383
Molecular FunctionGO:0005515protein bindingIPIJ:220505
Cellular ComponentGO:0016324apical plasma membraneISOJ:164563
Cellular ComponentGO:0016324apical plasma membraneISOJ:155856
Cellular ComponentGO:0016324apical plasma membraneIDAJ:106991
Cellular ComponentGO:0016323basolateral plasma membraneISOJ:155856
Cellular ComponentGO:0009986cell surfaceISOJ:164563
Cellular ComponentGO:0034707chloride channel complexIEAJ:60000
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0005737cytoplasmISOJ:155856
Cellular ComponentGO:0030659cytoplasmic vesicle membraneISOJ:155856
Cellular ComponentGO:0005829cytosolIDAJ:221546
Cellular ComponentGO:0005829cytosolISOJ:164563
Cellular ComponentGO:0005769early endosomeISOJ:164563
Cellular ComponentGO:0031205colocalizes_with
endoplasmic reticulum Sec complex
ISOJ:164563
Cellular ComponentGO:0005768endosomeIEAJ:60000
Cellular ComponentGO:0070062extracellular exosomeISOJ:164563
Cellular ComponentGO:0016021integral component of membraneIEAJ:72247
Cellular ComponentGO:0016021integral component of membraneIEAJ:60000
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0016020membraneIEAJ:72247
Cellular ComponentGO:0005902microvillusISOJ:155856
Cellular ComponentGO:0005886plasma membraneISOJ:164563
Cellular ComponentGO:0005886plasma membraneIDAJ:221546
Cellular ComponentGO:0043234protein complexISOJ:164563
Cellular ComponentGO:0055037recycling endosomeISOJ:164563
Biological ProcessGO:0015701bicarbonate transportISOJ:155856
Biological ProcessGO:0071320cellular response to cAMPIDAJ:185780
Biological ProcessGO:1902476chloride transmembrane transportIMPJ:221546
Biological ProcessGO:1902476chloride transmembrane transportISOJ:164563
Biological ProcessGO:0006821chloride transportISOJ:155856
Biological ProcessGO:0006821chloride transportIGIJ:144738
Biological ProcessGO:0006695cholesterol biosynthetic processIMPJ:121216
Biological ProcessGO:0030301cholesterol transportIMPJ:121216
Biological ProcessGO:0051454intracellular pH elevationIMPJ:185780
Biological ProcessGO:0015705iodide transportISOJ:155856
Biological ProcessGO:0006811ion transportIEAJ:72247
Biological ProcessGO:0006811ion transportIEAJ:60000
Biological ProcessGO:0030324lung developmentISOJ:155856
Biological ProcessGO:0060081membrane hyperpolarizationIMPJ:185780
Biological ProcessGO:1902161positive regulation of cyclic nucleotide-gated ion channel activityIMPJ:221546
Biological ProcessGO:1902161positive regulation of cyclic nucleotide-gated ion channel activityISOJ:164563
Biological ProcessGO:0045921positive regulation of exocytosisISOJ:164563
Biological ProcessGO:0045921positive regulation of exocytosisIMPJ:221546
Biological ProcessGO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulusISOJ:164563
Biological ProcessGO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulusIMPJ:221546
Biological ProcessGO:0045909positive regulation of vasodilationISOJ:155856
Biological ProcessGO:1902943positive regulation of voltage-gated chloride channel activityISOJ:164563
Biological ProcessGO:0048240sperm capacitationIMPJ:185780
Biological ProcessGO:0030321transepithelial chloride transportISOJ:155856
Biological ProcessGO:0055085transmembrane transportIEAJ:72247
Biological ProcessGO:0006810transportIEAJ:60000
Biological ProcessGO:0006810transportIEAJ:72247
Biological ProcessGO:0042311vasodilationISOJ:155856
Biological ProcessGO:0006904vesicle docking involved in exocytosisIMPJ:221546
Biological ProcessGO:0006833water transportISOJ:155856


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory