GO Annotations Graph

• Symbol: Cftr
• Name: cystic fibrosis transmembrane conductance regulator
• ID: MGI:88388

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0140359	ABC-type transporter activity	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0016887	ATP hydrolysis activity	ISO	J:164563
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	IBA	J:265628
Molecular Function	GO:0015106	bicarbonate transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0015106	bicarbonate transmembrane transporter activity	IMP	J:185780
Molecular Function	GO:0005254	chloride channel activity	ISO	J:164563
Molecular Function	GO:0005254	chloride channel activity	IMP	J:221546
Molecular Function	GO:0005254	chloride channel activity	IDA	J:158652
Molecular Function	GO:0019869	chloride channel inhibitor activity	ISO	J:164563
Molecular Function	GO:0015108	chloride transmembrane transporter activity	IMP	J:185780
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0005260	intracellularly ATP-gated chloride channel activity	ISO	J:164563
Molecular Function	GO:0016853	isomerase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:220505
Molecular Function	GO:0005515	protein binding	IPI	J:185780
Molecular Function	GO:0005515	protein binding	IPI	J:144738
Molecular Function	GO:0005515	protein binding	IPI	J:185780
Molecular Function	GO:0005515	protein binding	IPI	J:200383
Molecular Function	GO:0005515	protein binding	IPI	J:185780
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:164563
Molecular Function	GO:0106138	Sec61 translocon complex binding	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:176213
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IBA	J:265628
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:106991
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0034707	chloride channel complex	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:221546
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005769	early endosome	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005902	microvillus	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:221546
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0055037	recycling endosome	ISO	J:164563
Biological Process	GO:0097186	amelogenesis	IDA	J:306590
Biological Process	GO:0015701	bicarbonate transport	ISO	J:164563
Biological Process	GO:0015701	bicarbonate transport	ISO	J:155856
Biological Process	GO:0015701	bicarbonate transport	IBA	J:265628
Biological Process	GO:0071320	cellular response to cAMP	IDA	J:185780
Biological Process	GO:1904322	cellular response to forskolin	ISO	J:164563
Biological Process	GO:1902476	chloride transmembrane transport	IDA	J:158652
Biological Process	GO:1902476	chloride transmembrane transport	IDA	J:306590
Biological Process	GO:1902476	chloride transmembrane transport	IMP	J:221546
Biological Process	GO:1902476	chloride transmembrane transport	ISO	J:164563
Biological Process	GO:1902476	chloride transmembrane transport	IBA	J:265628
Biological Process	GO:0006821	chloride transport	ISO	J:155856
Biological Process	GO:0006821	chloride transport	IGI	J:144738
Biological Process	GO:0006695	cholesterol biosynthetic process	IMP	J:121216
Biological Process	GO:0030301	cholesterol transport	IMP	J:121216
Biological Process	GO:0070166	enamel mineralization	ISO	J:155856
Biological Process	GO:0051649	establishment of localization in cell	IGI	J:144738
Biological Process	GO:0051454	intracellular pH elevation	IMP	J:185780
Biological Process	GO:0030324	lung development	ISO	J:155856
Biological Process	GO:0060081	membrane hyperpolarization	IMP	J:185780
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0050891	multicellular organismal-level water homeostasis	ISO	J:164563
Biological Process	GO:2000077	negative regulation of type B pancreatic cell development	ISO	J:155856
Biological Process	GO:1905460	negative regulation of vascular associated smooth muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:1902161	positive regulation of cyclic nucleotide-gated ion channel activity	ISO	J:164563
Biological Process	GO:1902161	positive regulation of cyclic nucleotide-gated ion channel activity	IMP	J:221546
Biological Process	GO:0070175	positive regulation of enamel mineralization	IDA	J:306590
Biological Process	GO:1904446	positive regulation of establishment of Sertoli cell barrier	ISO	J:155856
Biological Process	GO:0045921	positive regulation of exocytosis	IMP	J:221546
Biological Process	GO:0045921	positive regulation of exocytosis	ISO	J:164563
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:164563
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	J:221546
Biological Process	GO:0033005	positive regulation of mast cell activation	ISO	J:155856
Biological Process	GO:1902943	positive regulation of voltage-gated chloride channel activity	ISO	J:164563
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0035725	sodium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0048240	sperm capacitation	IMP	J:185780
Biological Process	GO:0030321	transepithelial chloride transport	ISO	J:155856
Biological Process	GO:0035377	transepithelial water transport	ISO	J:164563
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247
Biological Process	GO:0042311	vasodilation	ISO	J:155856
Biological Process	GO:0006904	vesicle docking involved in exocytosis	IMP	J:221546
Biological Process	GO:0006833	water transport	ISO	J:155856