GO Annotations Graph

• Symbol: F2
• Name: coagulation factor II
• ID: MGI:88380

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0004175	endopeptidase activity	IMP	J:329322
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0001530	lipopolysaccharide binding	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	IMP	J:329322
Molecular Function	GO:0008233	peptidase activity	IMP	J:133917
Molecular Function	GO:0005515	protein binding	IPI	J:26852
Molecular Function	GO:0004252	serine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004252	serine-type endopeptidase activity	IBA	J:265628
Molecular Function	GO:0004252	serine-type endopeptidase activity	IDA	J:139818
Molecular Function	GO:0004252	serine-type endopeptidase activity	IDA	J:139818
Molecular Function	GO:0008236	serine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0070053	thrombospondin receptor activity	ISO	J:164563
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ISO	J:155856
Cellular Component	GO:0062023	collagen-containing extracellular matrix	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:1905370	serine-type endopeptidase complex	ISO	J:164563
Biological Process	GO:0006953	acute-phase response	IEA	J:60000
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	ISO	J:164563
Biological Process	GO:0007596	blood coagulation	ISO	J:155856
Biological Process	GO:0072377	blood coagulation, common pathway	ISO	J:164563
Biological Process	GO:0007166	cell surface receptor signaling pathway	ISO	J:164563
Biological Process	GO:0051838	cytolysis by host of symbiont cells	ISO	J:164563
Biological Process	GO:0042730	fibrinolysis	ISO	J:164563
Biological Process	GO:0007599	hemostasis	IEA	J:60000
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	IDA	J:329322
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	IMP	J:329322
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	IDA	J:329322
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	IMP	J:329322
Biological Process	GO:0048712	negative regulation of astrocyte differentiation	ISO	J:164563
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	ISO	J:164563
Biological Process	GO:0045861	negative regulation of proteolysis	ISO	J:164563
Biological Process	GO:0070945	neutrophil-mediated killing of gram-negative bacterium	ISO	J:164563
Biological Process	GO:0030168	platelet activation	ISO	J:164563
Biological Process	GO:0030168	platelet activation	IBA	J:265628
Biological Process	GO:0030168	platelet activation	IDA	J:121278
Biological Process	GO:0030194	positive regulation of blood coagulation	ISO	J:164563
Biological Process	GO:0030194	positive regulation of blood coagulation	ISO	J:155856
Biological Process	GO:0030194	positive regulation of blood coagulation	IBA	J:265628
Biological Process	GO:0030307	positive regulation of cell growth	IGI	J:139818
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:139818
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:164563
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:329322
Biological Process	GO:0032024	positive regulation of insulin secretion	IDA	J:329322
Biological Process	GO:0090218	positive regulation of lipid kinase activity	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IGI	J:139818
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IGI	J:139818
Biological Process	GO:1900738	positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0008360	regulation of cell shape	IGI	J:139818
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IDA	J:138062
Biological Process	GO:0009611	response to wounding	ISO	J:164563
Biological Process	GO:0070493	thrombin-activated receptor signaling pathway	ISO	J:139818
Biological Process	GO:0031638	zymogen activation	ISO	J:164563