GO Annotations Graph

• Symbol: Cacna2d1
• Name: calcium channel, voltage-dependent, alpha2/delta subunit 1
• ID: MGI:88295

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005262	calcium channel activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:188385
Molecular Function	GO:0005515	protein binding	IPI	J:121567
Molecular Function	GO:0005245	voltage-gated calcium channel activity	ISO	J:164563
Molecular Function	GO:0005245	voltage-gated calcium channel activity	ISO	J:164563
Molecular Function	GO:0005245	voltage-gated calcium channel activity	ISO	J:155856
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IBA	J:265628
Molecular Function	GO:0086057	voltage-gated calcium channel activity involved in bundle of His cell action potential	ISO	J:164563
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:1990454	L-type voltage-gated calcium channel complex	ISO	J:164563
Cellular Component	GO:1990454	L-type voltage-gated calcium channel complex	ISO	J:155856
Cellular Component	GO:1990454	L-type voltage-gated calcium channel complex	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	EXP	J:326640
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0048787	presynaptic active zone membrane	ISO	J:155856
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:96149
Cellular Component	GO:0030315	T-tubule	IDA	J:96149
Cellular Component	GO:0005891	voltage-gated calcium channel complex	ISO	J:155856
Cellular Component	GO:0005891	voltage-gated calcium channel complex	ISO	J:164563
Cellular Component	GO:0005891	voltage-gated calcium channel complex	IMP	J:247020
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0070588	calcium ion transmembrane transport	NAS	J:320086
Biological Process	GO:0061577	calcium ion transmembrane transport via high voltage-gated calcium channel	ISO	J:155856
Biological Process	GO:0006816	calcium ion transport	ISO	J:164563
Biological Process	GO:0060402	calcium ion transport into cytosol	ISO	J:155856
Biological Process	GO:0086002	cardiac muscle cell action potential involved in contraction	ISO	J:164563
Biological Process	GO:1904646	cellular response to amyloid-beta	ISO	J:164563
Biological Process	GO:0086048	membrane depolarization during bundle of His cell action potential	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:1901843	positive regulation of high voltage-gated calcium channel activity	ISO	J:155856
Biological Process	GO:0045933	positive regulation of muscle contraction	NAS	J:320086
Biological Process	GO:1901387	positive regulation of voltage-gated calcium channel activity	ISO	J:155856
Biological Process	GO:1902514	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISO	J:164563
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:164563
Biological Process	GO:0051924	regulation of calcium ion transport	IMP	J:96149
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	ISO	J:164563
Biological Process	GO:0098903	regulation of membrane repolarization during action potential	ISO	J:155856
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	ISO	J:164563