Cacna1s GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Cacna1s
calcium channel, voltage-dependent, L type, alpha 1S subunit
MGI:88294

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005262	calcium channel activity	IEA	J:60000
Molecular Function	GO:0005516	calmodulin binding	IEA	J:60000
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	ISO	J:155856
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	ISO	J:164563
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0036094	small molecule binding	ISO	J:164563
Molecular Function	GO:0005245	voltage-gated calcium channel activity	ISO	J:164563
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IMP	J:103273
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IDA	J:87930
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0044327	dendritic spine head	ISO	J:155856
Cellular Component	GO:0031674	I band	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:37052
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:104730
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:87930
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:96149
Cellular Component	GO:0030315	T-tubule	ISO	J:164563
Cellular Component	GO:0030315	T-tubule	IDA	J:96149
Cellular Component	GO:0030315	T-tubule	IDA	J:37052
Cellular Component	GO:0030315	T-tubule	IDA	J:56913
Cellular Component	GO:0005891	voltage-gated calcium channel complex	ISO	J:155856
Cellular Component	GO:0005891	voltage-gated calcium channel complex	ISO	J:164563
Cellular Component	GO:0005891	voltage-gated calcium channel complex	IBA	J:265628
Biological Process	GO:0098703	calcium ion import across plasma membrane	IBA	J:265628
Biological Process	GO:0070588	calcium ion transmembrane transport	NAS	J:320086
Biological Process	GO:0006816	calcium ion transport	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	ISO	J:155856
Biological Process	GO:0006816	calcium ion transport	IMP	J:641
Biological Process	GO:0006816	calcium ion transport	IMP	J:115325
Biological Process	GO:0006816	calcium ion transport	IDA	J:87930
Biological Process	GO:0006816	calcium ion transport	IMP	J:103273
Biological Process	GO:0007029	endoplasmic reticulum organization	IMP	J:5283
Biological Process	GO:0002074	extraocular skeletal muscle development	IMP	J:105090
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0055001	muscle cell development	IMP	J:5283
Biological Process	GO:0006936	muscle contraction	ISO	J:164563
Biological Process	GO:0006936	muscle contraction	IMP	J:15029
Biological Process	GO:0006936	muscle contraction	IDA	J:18533
Biological Process	GO:0006936	muscle contraction	IMP	J:7390
Biological Process	GO:0006936	muscle contraction	IMP	J:5371
Biological Process	GO:0007520	myoblast fusion	IMP	J:106306
Biological Process	GO:0007528	neuromuscular junction development	IMP	J:7296
Biological Process	GO:0007528	neuromuscular junction development	IMP	J:6592
Biological Process	GO:0007528	neuromuscular junction development	IMP	J:7295
Biological Process	GO:0045933	positive regulation of muscle contraction	NAS	J:320086
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:0043501	skeletal muscle adaptation	IMP	J:105758
Biological Process	GO:0048741	skeletal muscle fiber development	IMP	J:109963
Biological Process	GO:0048741	skeletal muscle fiber development	IMP	J:4724
Biological Process	GO:0048741	skeletal muscle fiber development	IDA	J:18533
Biological Process	GO:0007519	skeletal muscle tissue development	IMP	J:14970
Biological Process	GO:0007519	skeletal muscle tissue development	IMP	J:7644
Biological Process	GO:0007519	skeletal muscle tissue development	IMP	J:28645
Biological Process	GO:0007519	skeletal muscle tissue development	IMP	J:4466
Biological Process	GO:0001501	skeletal system development	IMP	J:7655
Biological Process	GO:0006941	striated muscle contraction	IMP	J:3462
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23