GO Annotations Graph

• Symbol: Cacna1d
• Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
• ID: MGI:88293

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051393	alpha-actinin binding	ISO	J:164563
Molecular Function	GO:0030506	ankyrin binding	ISO	J:155856
Molecular Function	GO:0030506	ankyrin binding	IPI	J:185021
Molecular Function	GO:0005262	calcium channel activity	ISO	J:164563
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	ISO	J:155856
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	ISO	J:164563
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	IBA	J:265628
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	IDA	J:86180
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:119891
Molecular Function	GO:0005245	voltage-gated calcium channel activity	ISO	J:164563
Molecular Function	GO:0005245	voltage-gated calcium channel activity	ISO	J:155856
Molecular Function	GO:0099635	voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels	TAS	Reactome:R-MMU-9659489
Molecular Function	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	IMP	J:63515
Molecular Function	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	IDA	J:63515
Molecular Function	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	IDA	J:63515
Molecular Function	GO:0086059	voltage-gated calcium channel activity involved SA node cell action potential	ISO	J:164563
Molecular Function	GO:0086059	voltage-gated calcium channel activity involved SA node cell action potential	IMP	J:151611
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0098683	cochlear hair cell ribbon synapse	IDA	J:63515
Cellular Component	GO:0098683	cochlear hair cell ribbon synapse	IDA	J:63515
Cellular Component	GO:0098683	cochlear hair cell ribbon synapse	IMP	J:63515
Cellular Component	GO:0098683	cochlear hair cell ribbon synapse	IDA	J:263450
Cellular Component	GO:0098683	cochlear hair cell ribbon synapse	IDA	J:263450
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0032590	dendrite membrane	ISO	J:155856
Cellular Component	GO:1990454	L-type voltage-gated calcium channel complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:185021
Cellular Component	GO:0005886	plasma membrane	IDA	J:186061
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-525831
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9659489
Cellular Component	GO:0005886	plasma membrane	IC	J:86180
Cellular Component	GO:0005886	plasma membrane	IDA	J:119891
Cellular Component	GO:0048787	presynaptic active zone membrane	IDA	J:263450
Cellular Component	GO:0048787	presynaptic active zone membrane	IDA	J:263450
Cellular Component	GO:0150001	primary dendrite	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0005891	voltage-gated calcium channel complex	ISO	J:164563
Cellular Component	GO:0005891	voltage-gated calcium channel complex	IBA	J:265628
Cellular Component	GO:0005891	voltage-gated calcium channel complex	TAS	J:76458
Cellular Component	GO:0030018	Z disc	IDA	J:130245
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP	J:108922
Biological Process	GO:0070509	calcium ion import	ISO	J:164563
Biological Process	GO:0070509	calcium ion import	ISO	J:155856
Biological Process	GO:0098703	calcium ion import across plasma membrane	IBA	J:265628
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:99822
Biological Process	GO:0006816	calcium ion transport	ISO	J:155856
Biological Process	GO:0006816	calcium ion transport	ISO	J:164563
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:155856
Biological Process	GO:0086002	cardiac muscle cell action potential involved in contraction	ISO	J:164563
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:99822
Biological Process	GO:0086046	membrane depolarization during SA node cell action potential	ISO	J:164563
Biological Process	GO:0086046	membrane depolarization during SA node cell action potential	IMP	J:99822
Biological Process	GO:0030001	metal ion transport	ISO	J:155856
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0045762	positive regulation of adenylate cyclase activity	IDA	J:266464
Biological Process	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISO	J:155856
Biological Process	GO:0051928	positive regulation of calcium ion transport	ISO	J:164563
Biological Process	GO:0032793	positive regulation of CREB transcription factor activity	ISO	J:155856
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:1904181	positive regulation of membrane depolarization	ISO	J:155856
Biological Process	GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization	IMP	J:130245
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	ISO	J:164563
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	IMP	J:99822
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:1901379	regulation of potassium ion transmembrane transport	IMP	J:130245
Biological Process	GO:1901016	regulation of potassium ion transmembrane transporter activity	IMP	J:130245
Biological Process	GO:0007605	sensory perception of sound	ISO	J:164563
Biological Process	GO:0007605	sensory perception of sound	IMP	J:117764
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247