GO Annotations Graph

• Symbol: Atp1a1
• Name: ATPase, Na+/K+ transporting, alpha 1 polypeptide
• ID: MGI:88105

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043531	ADP binding	ISO	J:155856
Molecular Function	GO:0030506	ankyrin binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0016887	ATP hydrolysis activity	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:72247
Molecular Function	GO:0008556	P-type potassium transmembrane transporter activity	IEA	J:72247
Molecular Function	GO:0005391	P-type sodium:potassium-exchanging transporter activity	ISO	J:155856
Molecular Function	GO:0005391	P-type sodium:potassium-exchanging transporter activity	ISO	J:164563
Molecular Function	GO:0005391	P-type sodium:potassium-exchanging transporter activity	IBA	J:265628
Molecular Function	GO:0005391	P-type sodium:potassium-exchanging transporter activity	IDA	J:203477
Molecular Function	GO:0005391	P-type sodium:potassium-exchanging transporter activity	IMP	J:55191
Molecular Function	GO:0005391	P-type sodium:potassium-exchanging transporter activity	IMP	J:95157
Molecular Function	GO:0016791	phosphatase activity	IMP	J:55191
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	ISO	J:155856
Molecular Function	GO:0030955	potassium ion binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:103813
Molecular Function	GO:0005515	protein binding	IPI	J:103813
Molecular Function	GO:0005515	protein binding	IPI	J:95157
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:164563
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:155856
Molecular Function	GO:0031402	sodium ion binding	ISO	J:155856
Molecular Function	GO:1990239	steroid hormone binding	ISO	J:164563
Molecular Function	GO:0005215	transporter activity	IEA	J:72247
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:176751
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:183948
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:18532
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0014704	intercalated disc	ISO	J:155856
Cellular Component	GO:0016328	lateral plasma membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:99929
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0031090	organelle membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:62912
Cellular Component	GO:0005886	plasma membrane	IDA	J:62912
Cellular Component	GO:0005886	plasma membrane	IDA	J:62912
Cellular Component	GO:0005886	plasma membrane	IDA	J:119891
Cellular Component	GO:0014069	postsynaptic density	IDA	J:187362
Cellular Component	GO:0032991	protein-containing complex	ISO	J:199676
Cellular Component	GO:0042383	sarcolemma	IDA	J:103813
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	IBA	J:265628
Cellular Component	GO:0042383	sarcolemma	IDA	J:95157
Cellular Component	GO:0005890	sodium:potassium-exchanging ATPase complex	ISO	J:164563
Cellular Component	GO:0005890	sodium:potassium-exchanging ATPase complex	ISO	J:155856
Cellular Component	GO:0005890	sodium:potassium-exchanging ATPase complex	IBA	J:265628
Cellular Component	GO:0036126	sperm flagellum	ISO	J:164563
Cellular Component	GO:0030315	T-tubule	IDA	J:103813
Cellular Component	GO:0030315	T-tubule	ISO	J:155856
Cellular Component	GO:0030315	T-tubule	ISO	J:164563
Biological Process	GO:0071260	cellular response to mechanical stimulus	ISO	J:155856
Biological Process	GO:0071383	cellular response to steroid hormone stimulus	ISO	J:164563
Biological Process	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient	IMP	J:55191
Biological Process	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient	NAS	J:319965
Biological Process	GO:0060047	heart contraction	IMP	J:55191
Biological Process	GO:0030007	intracellular potassium ion homeostasis	ISO	J:164563
Biological Process	GO:0030007	intracellular potassium ion homeostasis	IBA	J:265628
Biological Process	GO:0006883	intracellular sodium ion homeostasis	ISO	J:164563
Biological Process	GO:0006883	intracellular sodium ion homeostasis	IBA	J:265628
Biological Process	GO:0060081	membrane hyperpolarization	ISO	J:155856
Biological Process	GO:0086009	membrane repolarization	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0031947	negative regulation of glucocorticoid biosynthetic process	IMP	J:117414
Biological Process	GO:0045822	negative regulation of heart contraction	IMP	J:95157
Biological Process	GO:0045823	positive regulation of heart contraction	IMP	J:55191
Biological Process	GO:0045989	positive regulation of striated muscle contraction	IMP	J:114415
Biological Process	GO:1990573	potassium ion import across plasma membrane	ISO	J:164563
Biological Process	GO:1990573	potassium ion import across plasma membrane	ISO	J:155856
Biological Process	GO:1990573	potassium ion import across plasma membrane	IBA	J:265628
Biological Process	GO:0071805	potassium ion transmembrane transport	IMP	J:55191
Biological Process	GO:0006813	potassium ion transport	ISO	J:155856
Biological Process	GO:1902600	proton transmembrane transport	NAS	J:319965
Biological Process	GO:1902600	proton transmembrane transport	IBA	J:265628
Biological Process	GO:0008217	regulation of blood pressure	IGI	J:102928
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	ISO	J:155856
Biological Process	GO:0002028	regulation of sodium ion transport	ISO	J:155856
Biological Process	GO:0002026	regulation of the force of heart contraction	IMP	J:55191
Biological Process	GO:0002026	regulation of the force of heart contraction	IMP	J:95157
Biological Process	GO:0009410	response to xenobiotic stimulus	IMP	J:117414
Biological Process	GO:0036376	sodium ion export across plasma membrane	ISO	J:155856
Biological Process	GO:0036376	sodium ion export across plasma membrane	ISO	J:164563
Biological Process	GO:0036376	sodium ion export across plasma membrane	IBA	J:265628
Biological Process	GO:0035725	sodium ion transmembrane transport	IMP	J:55191
Biological Process	GO:0006814	sodium ion transport	ISO	J:155856
Biological Process	GO:0055085	transmembrane transport	ISO	J:155856