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GO Annotations Graph
Symbol
Name
ID
App
amyloid beta (A4) precursor protein
MGI:88059

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0033130acetylcholine receptor bindingISOJ:164563
Molecular FunctionGO:0003677DNA bindingIDAJ:100260
Molecular FunctionGO:0019899enzyme bindingISOJ:164563
Molecular FunctionGO:0070851growth factor receptor bindingISOJ:155856
Molecular FunctionGO:0008201heparin bindingIEAJ:60000
Molecular FunctionGO:0008201heparin bindingIEAJ:72247
Molecular FunctionGO:0042802identical protein bindingISOJ:164563
Molecular FunctionGO:0046872metal ion bindingIEAJ:60000
Molecular FunctionGO:0016504peptidase activator activityISOJ:155856
Molecular FunctionGO:0030414peptidase inhibitor activityIEAJ:60000
Molecular FunctionGO:0005515protein bindingIPIJ:163792
Molecular FunctionGO:0005515protein bindingIPIJ:118164
Molecular FunctionGO:0005515protein bindingIPIJ:126870
Molecular FunctionGO:0005515protein bindingIPIJ:174507
Molecular FunctionGO:0005515protein bindingIPIJ:57129
Molecular FunctionGO:0005515protein bindingIPIJ:174472
Molecular FunctionGO:0005515protein bindingIPIJ:76516
Molecular FunctionGO:0005515protein bindingIPIJ:167925
Molecular FunctionGO:0005515protein bindingIPIJ:143818
Molecular FunctionGO:0005515protein bindingIPIJ:182473
Molecular FunctionGO:0005515protein bindingIPIJ:114737
Molecular FunctionGO:0005515protein bindingIPIJ:143818
Molecular FunctionGO:0005515protein bindingIPIJ:154833
Molecular FunctionGO:0005515protein bindingIPIJ:145671
Molecular FunctionGO:0005515protein bindingIPIJ:85533
Molecular FunctionGO:0005515protein bindingIPIJ:206895
Molecular FunctionGO:0005515protein bindingIPIJ:206895
Molecular FunctionGO:0005515protein bindingIPIJ:103763
Molecular FunctionGO:0005515protein bindingIPIJ:114052
Molecular FunctionGO:0051425PTB domain bindingISOJ:164563
Molecular FunctionGO:0005102receptor bindingISOJ:164563
Molecular FunctionGO:0004867serine-type endopeptidase inhibitor activityISOJ:164563
Molecular FunctionGO:0046914transition metal ion bindingIEAJ:72247
Cellular ComponentGO:0045177apical part of cellIDAJ:95286
Cellular ComponentGO:0097449astrocyte projectionISOJ:155856
Cellular ComponentGO:0030424axonIDAJ:73257
Cellular ComponentGO:0030424axonISOJ:155856
Cellular ComponentGO:0030424axonIDAJ:98609
Cellular ComponentGO:0009986cell surfaceISOJ:164563
Cellular ComponentGO:0009986cell surfaceISOJ:155856
Cellular ComponentGO:0005911cell-cell junctionIDAJ:205441
Cellular ComponentGO:0035253ciliary rootletIDAJ:102734
Cellular ComponentGO:0005905coated pitIEAJ:60000
Cellular ComponentGO:0005737cytoplasmIDAJ:63791
Cellular ComponentGO:0005737cytoplasmISOJ:155856
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0031410cytoplasmic vesicleIDAJ:98609
Cellular ComponentGO:0031410cytoplasmic vesicleIDAJ:73257
Cellular ComponentGO:0005768endosomeISOJ:164563
Cellular ComponentGO:0030134ER to Golgi transport vesicleIDAJ:158452
Cellular ComponentGO:0070062extracellular exosomeISOJ:164563
Cellular ComponentGO:0005615extracellular spaceISOJ:164563
Cellular ComponentGO:0005615extracellular spaceISOJ:155856
Cellular ComponentGO:0005794Golgi apparatusISOJ:155856
Cellular ComponentGO:0005794Golgi apparatusISOJ:164563
Cellular ComponentGO:0005794Golgi apparatusIDAJ:102734
Cellular ComponentGO:0030426growth coneISOJ:155856
Cellular ComponentGO:1990812growth cone filopodiumISOJ:155856
Cellular ComponentGO:1990761growth cone lamellipodiumISOJ:155856
Cellular ComponentGO:0016021integral component of membraneIDAJ:85358
Cellular ComponentGO:0043231intracellular membrane-bounded organelleISOJ:164563
Cellular ComponentGO:0044304main axonISOJ:155856
Cellular ComponentGO:0016020membraneIDAJ:46769
Cellular ComponentGO:0016020membraneTASJ:76516
Cellular ComponentGO:0016020membraneIDAJ:100835
Cellular ComponentGO:0016020membraneIDAJ:63791
Cellular ComponentGO:0016020membraneIDAJ:85358
Cellular ComponentGO:0045121membrane raftISOJ:164563
Cellular ComponentGO:0031594neuromuscular junctionIDAJ:63791
Cellular ComponentGO:0043005neuron projectionISOJ:155856
Cellular ComponentGO:0043005neuron projectionIDAJ:104505
Cellular ComponentGO:0005641nuclear envelope lumenISOJ:164563
Cellular ComponentGO:0048471perinuclear region of cytoplasmISOJ:164563
Cellular ComponentGO:0048471perinuclear region of cytoplasmIDAJ:18694
Cellular ComponentGO:0005886plasma membraneISOJ:164563
Cellular ComponentGO:0005886plasma membraneIDAJ:107993
Cellular ComponentGO:0005886plasma membraneISOJ:155856
Cellular ComponentGO:0043235receptor complexISOJ:194542
Cellular ComponentGO:0005791rough endoplasmic reticulumISOJ:155856
Cellular ComponentGO:0051233spindle midzoneIDAJ:95286
Cellular ComponentGO:0043195terminal boutonISOJ:155856
Biological ProcessGO:0008344adult locomotory behaviorIMPJ:21937
Biological ProcessGO:0008344adult locomotory behaviorIMPJ:53824
Biological ProcessGO:0008344adult locomotory behaviorIMPJ:49959
Biological ProcessGO:0008344adult locomotory behaviorIMPJ:25512
Biological ProcessGO:1990000amyloid fibril formationISOJ:164563
Biological ProcessGO:0019731antibacterial humoral responseISOJ:164563
Biological ProcessGO:0019731antibacterial humoral responseISOJ:155856
Biological ProcessGO:0019732antifungal humoral responseISOJ:155856
Biological ProcessGO:0019732antifungal humoral responseISOJ:164563
Biological ProcessGO:0006915apoptotic processIEAJ:60000
Biological ProcessGO:0008088axo-dendritic transportIMPJ:73257
Biological ProcessGO:0008088axo-dendritic transportIGIJ:164887
Biological ProcessGO:0016199axon midline choice point recognitionIMPJ:21937
Biological ProcessGO:0007409axonogenesisIMPJ:101975
Biological ProcessGO:0007155cell adhesionIEAJ:60000
Biological ProcessGO:0006878cellular copper ion homeostasisIMPJ:58021
Biological ProcessGO:0006878cellular copper ion homeostasisIGIJ:93279
Biological ProcessGO:0009987cellular processISOJ:164563
Biological ProcessGO:0071874cellular response to norepinephrine stimulusISOJ:155856
Biological ProcessGO:0008203cholesterol metabolic processIMPJ:126954
Biological ProcessGO:0008203cholesterol metabolic processIGIJ:126954
Biological ProcessGO:0048669collateral sprouting in absence of injuryIGIJ:98108
Biological ProcessGO:0050829defense response to Gram-negative bacteriumISOJ:155856
Biological ProcessGO:0050829defense response to Gram-negative bacteriumISOJ:164563
Biological ProcessGO:0050830defense response to Gram-positive bacteriumISOJ:164563
Biological ProcessGO:0050830defense response to Gram-positive bacteriumISOJ:155856
Biological ProcessGO:0016358dendrite developmentIGIJ:98108
Biological ProcessGO:0016358dendrite developmentIMPJ:101975
Biological ProcessGO:0016358dendrite developmentIMPJ:53824
Biological ProcessGO:0006897endocytosisIMPJ:101438
Biological ProcessGO:0030198extracellular matrix organizationIGIJ:93306
Biological ProcessGO:0030900forebrain developmentIMPJ:21937
Biological ProcessGO:0030900forebrain developmentIMPJ:54584
Biological ProcessGO:0045087innate immune responseISOJ:155856
Biological ProcessGO:0045087innate immune responseISOJ:164563
Biological ProcessGO:0035235ionotropic glutamate receptor signaling pathwayIMPJ:101438
Biological ProcessGO:0007626locomotory behaviorIGIJ:45851
Biological ProcessGO:0007617mating behaviorIGIJ:45851
Biological ProcessGO:0006378mRNA polyadenylationIDAJ:103763
Biological ProcessGO:0010951negative regulation of endopeptidase activityISOJ:164563
Biological ProcessGO:0045665negative regulation of neuron differentiationIDAJ:145671
Biological ProcessGO:0045665negative regulation of neuron differentiationIGIJ:145671
Biological ProcessGO:0010466negative regulation of peptidase activityIEAJ:60000
Biological ProcessGO:0007399nervous system developmentIEAJ:72247
Biological ProcessGO:0050885neuromuscular process controlling balanceIGIJ:45851
Biological ProcessGO:0051402neuron apoptotic processIGIJ:106153
Biological ProcessGO:0051402neuron apoptotic processISOJ:164563
Biological ProcessGO:0031175neuron projection developmentIDAJ:20179
Biological ProcessGO:0016322neuron remodelingIMPJ:54292
Biological ProcessGO:0007219Notch signaling pathwayIEAJ:60000
Biological ProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleIMPJ:95286
Biological ProcessGO:0045931positive regulation of mitotic cell cycleIMPJ:95286
Biological ProcessGO:0010952positive regulation of peptidase activityISOJ:155856
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIDAJ:100260
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIGIJ:100260
Biological ProcessGO:0051260protein homooligomerizationISOJ:201575
Biological ProcessGO:0006468protein phosphorylationIMPJ:101438
Biological ProcessGO:0007176regulation of epidermal growth factor-activated receptor activityIGIJ:122380
Biological ProcessGO:0010468regulation of gene expressionIDAJ:101575
Biological ProcessGO:0040014regulation of multicellular organism growthIMPJ:49959
Biological ProcessGO:0043393regulation of protein bindingIGIJ:126954
Biological ProcessGO:0043393regulation of protein bindingIMPJ:126954
Biological ProcessGO:0050803regulation of synapse structure or activityIMPJ:54292
Biological ProcessGO:0006417regulation of translationIDAJ:103763
Biological ProcessGO:0006979response to oxidative stressIGIJ:106153
Biological ProcessGO:0001878response to yeastISOJ:155856
Biological ProcessGO:0001878response to yeastISOJ:164563
Biological ProcessGO:0051563smooth endoplasmic reticulum calcium ion homeostasisIGIJ:81726
Biological ProcessGO:0001967suckling behaviorIGIJ:45851
Biological ProcessGO:0051124synaptic growth at neuromuscular junctionIGIJ:98108
Biological ProcessGO:0008542visual learningIMPJ:57197


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory