GO Annotations Graph

• Symbol: Alox15
• Name: arachidonate 15-lipoxygenase
• ID: MGI:87997

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	ISO	J:155856
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	ISO	J:164563
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	IDA	J:18190
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	IBA	J:265628
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ISO	J:164563
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	IDA	J:18190
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ISO	J:155856
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	IBA	J:265628
Molecular Function	GO:0051213	dioxygenase activity	IEA	J:60000
Molecular Function	GO:0051120	hepoxilin A3 synthase activity	ISO	J:155856
Molecular Function	GO:0047977	hepoxilin-epoxide hydrolase activity	ISO	J:155856
Molecular Function	GO:0005506	iron ion binding	IEA	J:72247
Molecular Function	GO:0016165	linoleate 13S-lipoxygenase activity	ISO	J:164563
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	J:72247
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:120937
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IDA	J:200335
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005811	lipid droplet	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:200335
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0043277	apoptotic cell clearance	IMP	J:187327
Biological Process	GO:0019369	arachidonic acid metabolic process	IMP	J:44778
Biological Process	GO:0019369	arachidonic acid metabolic process	ISO	J:155856
Biological Process	GO:0019369	arachidonic acid metabolic process	IDA	J:18190
Biological Process	GO:0019369	arachidonic acid metabolic process	ISO	J:164563
Biological Process	GO:0030282	bone mineralization	IMP	J:87403
Biological Process	GO:0071277	cellular response to calcium ion	ISO	J:164563
Biological Process	GO:0035963	cellular response to interleukin-13	ISO	J:164563
Biological Process	GO:0006631	fatty acid metabolic process	IEA	J:60000
Biological Process	GO:0051122	hepoxilin biosynthetic process	ISO	J:155856
Biological Process	GO:0043651	linoleic acid metabolic process	ISO	J:164563
Biological Process	GO:0043651	linoleic acid metabolic process	IBA	J:265628
Biological Process	GO:0006629	lipid metabolic process	ISO	J:164563
Biological Process	GO:0034440	lipid oxidation	IBA	J:265628
Biological Process	GO:2001303	lipoxin A4 biosynthetic process	IMP	J:98733
Biological Process	GO:0019372	lipoxygenase pathway	ISO	J:164563
Biological Process	GO:0019372	lipoxygenase pathway	ISO	J:155856
Biological Process	GO:0019372	lipoxygenase pathway	IDA	J:18190
Biological Process	GO:0019372	lipoxygenase pathway	IMP	J:44778
Biological Process	GO:0002820	negative regulation of adaptive immune response	IMP	J:187327
Biological Process	GO:0001503	ossification	IMP	J:87403
Biological Process	GO:0006646	phosphatidylethanolamine biosynthetic process	IMP	J:187327
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IMP	J:200335
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0034116	positive regulation of heterotypic cell-cell adhesion	ISO	J:155856
Biological Process	GO:1901074	regulation of engulfment of apoptotic cell	IMP	J:187327
Biological Process	GO:1901074	regulation of engulfment of apoptotic cell	IMP	J:200335
Biological Process	GO:0050727	regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0035358	regulation of peroxisome proliferator activated receptor signaling pathway	IMP	J:200339
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IMP	J:184646
Biological Process	GO:0042060	wound healing	IMP	J:98733