GO Annotations Graph

• Symbol: Agtr1a
• Name: angiotensin II receptor, type 1a
• ID: MGI:87964

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001596	angiotensin type I receptor activity	ISO	J:155856
Molecular Function	GO:0001596	angiotensin type I receptor activity	ISO	J:164563
Molecular Function	GO:0001596	angiotensin type I receptor activity	IBA	J:265628
Molecular Function	GO:0001596	angiotensin type I receptor activity	IDA	J:82904
Molecular Function	GO:0004945	angiotensin type II receptor activity	ISO	J:164563
Molecular Function	GO:0031711	bradykinin receptor binding	ISO	J:164563
Molecular Function	GO:0031748	D1 dopamine receptor binding	ISO	J:155856
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:55477
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:103853
Cellular Component	GO:0005737	cytoplasm	IDA	J:103853
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0012505	endomembrane system	ISO	J:155856
Cellular Component	GO:0005768	endosome	IDA	J:90272
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0031968	organelle outer membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:103853
Cellular Component	GO:0005886	plasma membrane	IDA	J:90272
Cellular Component	GO:0005886	plasma membrane	IDA	J:103853
Cellular Component	GO:0055037	recycling endosome	ISO	J:155856
Biological Process	GO:0042976	activation of Janus kinase activity	ISO	J:155856
Biological Process	GO:0038166	angiotensin-activated signaling pathway	ISO	J:164563
Biological Process	GO:0038166	angiotensin-activated signaling pathway	ISO	J:155856
Biological Process	GO:0001568	blood vessel development	IGI	J:46007
Biological Process	GO:0002035	brain renin-angiotensin system	IMP	J:121666
Biological Process	GO:0002035	brain renin-angiotensin system	IMP	J:103184
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:164563
Biological Process	GO:0060326	cell chemotaxis	ISO	J:164563
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	ISO	J:155856
Biological Process	GO:0042416	dopamine biosynthetic process	ISO	J:155856
Biological Process	GO:0042756	drinking behavior	ISO	J:155856
Biological Process	GO:0042756	drinking behavior	IMP	J:103184
Biological Process	GO:0042756	drinking behavior	IMP	J:78903
Biological Process	GO:0042756	drinking behavior	IGI	J:103184
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IC	J:82904
Biological Process	GO:0010467	gene expression	IMP	J:206174
Biological Process	GO:0007507	heart development	IMP	J:121666
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0006954	inflammatory response	IGI	J:148250
Biological Process	GO:0006954	inflammatory response	IGI	J:148250
Biological Process	GO:0001822	kidney development	ISO	J:164563
Biological Process	GO:0001822	kidney development	IGI	J:46007
Biological Process	GO:0001822	kidney development	IMP	J:78903
Biological Process	GO:0001822	kidney development	IGI	J:46007
Biological Process	GO:0001822	kidney development	IGI	J:46007
Biological Process	GO:0001822	kidney development	IMP	J:78903
Biological Process	GO:0001822	kidney development	IMP	J:78903
Biological Process	GO:0002034	maintenance of blood vessel diameter homeostasis by renin-angiotensin	ISO	J:164563
Biological Process	GO:0034392	negative regulation of smooth muscle cell apoptotic process	IMP	J:154247
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:78697
Biological Process	GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway	ISO	J:164563
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0045777	positive regulation of blood pressure	ISO	J:155856
Biological Process	GO:0045777	positive regulation of blood pressure	IGI	J:115136
Biological Process	GO:0045777	positive regulation of blood pressure	IDA	J:95908
Biological Process	GO:0045777	positive regulation of blood pressure	IMP	J:95908
Biological Process	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	ISO	J:155856
Biological Process	GO:1905665	positive regulation of calcium ion import across plasma membrane	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:1905920	positive regulation of CoA-transferase activity	ISO	J:164563
Biological Process	GO:0001819	positive regulation of cytokine production	IMP	J:156435
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	IBA	J:265628
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	ISO	J:164563
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	ISO	J:164563
Biological Process	GO:0032430	positive regulation of phospholipase A2 activity	ISO	J:164563
Biological Process	GO:0051247	positive regulation of protein metabolic process	ISO	J:164563
Biological Process	GO:0001921	positive regulation of receptor recycling	ISO	J:155856
Biological Process	GO:0032930	positive regulation of superoxide anion generation	ISO	J:155856
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	IMP	J:154247
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:255410
Biological Process	GO:0006885	regulation of pH	ISO	J:155856
Biological Process	GO:0002019	regulation of renal output by angiotensin	IMP	J:78903
Biological Process	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	IGI	J:46007
Biological Process	GO:1905459	regulation of vascular associated smooth muscle cell apoptotic process	IGI	J:154247
Biological Process	GO:0019229	regulation of vasoconstriction	ISO	J:164563
Biological Process	GO:0002001	renin secretion into blood stream	IMP	J:78903
Biological Process	GO:0002018	renin-angiotensin regulation of aldosterone production	ISO	J:155856
Biological Process	GO:0002018	renin-angiotensin regulation of aldosterone production	IMP	J:78903
Biological Process	GO:0043627	response to estrogen	ISO	J:155856
Biological Process	GO:0007266	Rho protein signal transduction	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:1990874	vascular associated smooth muscle cell proliferation	IMP	J:154247
Biological Process	GO:0042310	vasoconstriction	ISO	J:155856
Biological Process	GO:0046718	viral entry into host cell	ISO	J:164563