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GO Annotations Graph
Symbol
Name
ID
Pde5a
phosphodiesterase 5A, cGMP-specific
MGI:2651499

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:00475553',5'-cyclic-GMP phosphodiesterase activityISOJ:155856
Molecular FunctionGO:00041143',5'-cyclic-nucleotide phosphodiesterase activityIMPJ:153189
Molecular FunctionGO:0003824catalytic activityIEAJ:60000
Molecular FunctionGO:0030553cGMP bindingIDAJ:139897
Molecular FunctionGO:0030553cGMP bindingIDAJ:82087
Molecular FunctionGO:0004112cyclic-nucleotide phosphodiesterase activityIDAJ:82087
Molecular FunctionGO:0016787hydrolase activityIEAJ:60000
Molecular FunctionGO:0046872metal ion bindingIEAJ:60000
Molecular FunctionGO:0000166nucleotide bindingIEAJ:60000
Molecular FunctionGO:0008081phosphoric diester hydrolase activityIEAJ:72247
Cellular ComponentGO:0005829cytosolISOJ:155856
Biological ProcessGO:0046069cGMP catabolic processISOJ:164563
Biological ProcessGO:0046069cGMP catabolic processIDAJ:82087
Biological ProcessGO:0046068cGMP metabolic processIMPJ:164532
Biological ProcessGO:0046068cGMP metabolic processIMPJ:153189
Biological ProcessGO:0008152metabolic processIEAJ:60000
Biological ProcessGO:0055118negative regulation of cardiac muscle contractionIMPJ:146192
Biological ProcessGO:0042130negative regulation of T cell proliferationIMPJ:124590
Biological ProcessGO:0043065positive regulation of apoptotic processISOJ:155856
Biological ProcessGO:0010613positive regulation of cardiac muscle hypertrophyIMPJ:146192
Biological ProcessGO:0002678positive regulation of chronic inflammatory responseISOJ:155856
Biological ProcessGO:0045745positive regulation of G-protein coupled receptor protein signaling pathwayICJ:146192
Biological ProcessGO:0043406positive regulation of MAP kinase activityIMPJ:146192
Biological ProcessGO:0060282positive regulation of oocyte developmentIGIJ:153189
Biological ProcessGO:0060282positive regulation of oocyte developmentIMPJ:153189
Biological ProcessGO:0045907positive regulation of vasoconstrictionISOJ:155856
Biological ProcessGO:0030823regulation of cGMP metabolic processIGIJ:101420
Biological ProcessGO:0002026regulation of the force of heart contractionISOJ:155856
Biological ProcessGO:0055119relaxation of cardiac muscleIMPJ:146192
Biological ProcessGO:0007614short-term memoryISOJ:155856
Biological ProcessGO:0007165signal transductionIEAJ:72247


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/13/2022
MGI 6.21
The Jackson Laboratory