GO Annotations Graph

• Symbol: Pla2g3
• Name: phospholipase A2, group III
• ID: MGI:2444945

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	IMP	J:197334
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004623	phospholipase A2 activity	IEA	J:72247
Molecular Function	GO:0004623	phospholipase A2 activity	IEA	J:72245
Molecular Function	GO:0004620	phospholipase activity	IDA	J:256369
Cellular Component	GO:0005814	centriole	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0055037	recycling endosome	ISO	J:164563
Biological Process	GO:0001675	acrosome assembly	IMP	J:161462
Biological Process	GO:0050482	arachidonic acid secretion	IEA	J:72247
Biological Process	GO:0048468	cell development	IMP	J:197334
Biological Process	GO:0048469	cell maturation	IMP	J:256369
Biological Process	GO:0030030	cell projection organization	IEA	J:60000
Biological Process	GO:0060271	cilium assembly	ISO	J:164563
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	ISO	J:164563
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0019372	lipoxygenase pathway	IMP	J:161462
Biological Process	GO:0034374	low-density lipoprotein particle remodeling	ISO	J:164563
Biological Process	GO:0042116	macrophage activation	IDA	J:256369
Biological Process	GO:0043303	mast cell degranulation	IMP	J:197334
Biological Process	GO:1900222	negative regulation of amyloid-beta clearance	IDA	J:243822
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:243822
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:243822
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:243822
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:0046473	phosphatidic acid metabolic process	ISO	J:164563
Biological Process	GO:0046470	phosphatidylcholine metabolic process	ISO	J:164563
Biological Process	GO:0046470	phosphatidylcholine metabolic process	IMP	J:161462
Biological Process	GO:0046337	phosphatidylethanolamine metabolic process	ISO	J:164563
Biological Process	GO:0046471	phosphatidylglycerol metabolic process	ISO	J:164563
Biological Process	GO:0046488	phosphatidylinositol metabolic process	ISO	J:164563
Biological Process	GO:0006658	phosphatidylserine metabolic process	ISO	J:164563
Biological Process	GO:0006644	phospholipid metabolic process	IDA	J:256369
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	IMP	J:256369
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	IMP	J:256369
Biological Process	GO:1903595	positive regulation of histamine secretion by mast cell	ISO	J:164563
Biological Process	GO:1903595	positive regulation of histamine secretion by mast cell	IMP	J:197334
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	ISO	J:164563
Biological Process	GO:0060376	positive regulation of mast cell differentiation	IMP	J:197334
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:164563
Biological Process	GO:0010976	positive regulation of neuron projection development	IMP	J:289093
Biological Process	GO:0031394	positive regulation of prostaglandin biosynthetic process	IMP	J:197334
Biological Process	GO:0031394	positive regulation of prostaglandin biosynthetic process	ISO	J:164563
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	IMP	J:256369
Biological Process	GO:0002532	production of molecular mediator involved in inflammatory response	IMP	J:256369
Biological Process	GO:2001135	regulation of endocytic recycling	ISO	J:164563
Biological Process	GO:0007288	sperm axoneme assembly	IMP	J:161462