GO Annotations Graph

• Symbol: Nlrc3
• Name: NLR family, CARD domain containing 3
• ID: MGI:2444070

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	IDA	J:240431
Molecular Function	GO:0005515	protein binding	IPI	J:187586
Cellular Component	GO:0034451	centriolar satellite	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISS	J:114713
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	ISS	J:114713
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IGI	J:187586
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IMP	J:187586
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	IMP	J:209896
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:240431
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	IMP	J:240431
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IGI	J:187586
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:73065
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:187586
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:209896
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0045824	negative regulation of innate immune response	IMP	J:209896
Biological Process	GO:0032687	negative regulation of interferon-alpha production	IMP	J:209896
Biological Process	GO:0032688	negative regulation of interferon-beta production	IMP	J:209896
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	IMP	J:187586
Biological Process	GO:0032695	negative regulation of interleukin-12 production	IMP	J:187586
Biological Process	GO:0032715	negative regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IMP	J:209896
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IMP	J:187586
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISS	J:114713
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	IMP	J:240431
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IMP	J:187586
Biological Process	GO:0031396	regulation of protein ubiquitination	IDA	J:187586
Biological Process	GO:0031396	regulation of protein ubiquitination	IMP	J:187586
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:187586
Biological Process	GO:0042110	T cell activation	ISS	J:114713