GO Annotations Graph

• Symbol: Flcn
• Name: folliculin
• ID: MGI:2442184

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0004857	enzyme inhibitor activity	ISO	J:164563
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:164563
Molecular Function	GO:0005096	GTPase activator activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:201276
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0044291	cell-cell contact zone	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005929	cilium	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:164563
Cellular Component	GO:0005764	lysosome	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0030496	midbody	ISO	J:164563
Cellular Component	GO:0072686	mitotic spindle	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0072111	cell proliferation involved in kidney development	IMP	J:143922
Biological Process	GO:0072111	cell proliferation involved in kidney development	IMP	J:161878
Biological Process	GO:0072111	cell proliferation involved in kidney development	IMP	J:130978
Biological Process	GO:0072111	cell proliferation involved in kidney development	IMP	J:154667
Biological Process	GO:0072111	cell proliferation involved in kidney development	IMP	J:130978
Biological Process	GO:0072111	cell proliferation involved in kidney development	IMP	J:161878
Biological Process	GO:0007043	cell-cell junction assembly	IMP	J:196228
Biological Process	GO:0034198	cellular response to amino acid starvation	ISO	J:164563
Biological Process	GO:0009267	cellular response to starvation	ISO	J:164563
Biological Process	GO:0097009	energy homeostasis	IMP	J:192024
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:161878
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:130978
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IMP	J:173708
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IMP	J:130978
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IMP	J:130978
Biological Process	GO:0030097	hemopoiesis	IMP	J:173708
Biological Process	GO:0001701	in utero embryonic development	IMP	J:173708
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	IMP	J:173708
Biological Process	GO:0032418	lysosome localization	ISO	J:164563
Biological Process	GO:0016525	negative regulation of angiogenesis	NAS	J:192024
Biological Process	GO:2001170	negative regulation of ATP biosynthetic process	IMP	J:192024
Biological Process	GO:1903444	negative regulation of brown fat cell differentiation	IMP	J:285017
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:220672
Biological Process	GO:1901723	negative regulation of cell proliferation involved in kidney development	IMP	J:154667
Biological Process	GO:1901723	negative regulation of cell proliferation involved in kidney development	IMP	J:130978
Biological Process	GO:1901723	negative regulation of cell proliferation involved in kidney development	IMP	J:161878
Biological Process	GO:1901723	negative regulation of cell proliferation involved in kidney development	IMP	J:143922
Biological Process	GO:1901856	negative regulation of cellular respiration	IMP	J:192024
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	IMP	J:232555
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:196261
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:130978
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:161878
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IMP	J:173708
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IMP	J:130978
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:192024
Biological Process	GO:0045820	negative regulation of glycolytic process	ISO	J:164563
Biological Process	GO:1901859	negative regulation of mitochondrial DNA metabolic process	IMP	J:192024
Biological Process	GO:0010823	negative regulation of mitochondrion organization	IMP	J:192024
Biological Process	GO:1901862	negative regulation of muscle tissue development	IMP	J:192024
Biological Process	GO:1901874	negative regulation of post-translational protein modification	IMP	J:196261
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IMP	J:154667
Biological Process	GO:1900181	negative regulation of protein localization to nucleus	ISO	J:164563
Biological Process	GO:0035024	negative regulation of Rho protein signal transduction	ISO	J:164563
Biological Process	GO:0032007	negative regulation of TOR signaling	IMP	J:130978
Biological Process	GO:0032007	negative regulation of TOR signaling	IMP	J:143922
Biological Process	GO:0032007	negative regulation of TOR signaling	IMP	J:173708
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:196261
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	IMP	J:173708
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IMP	J:196261
Biological Process	GO:0032008	positive regulation of TOR signaling	ISO	J:164563
Biological Process	GO:0032008	positive regulation of TOR signaling	IMP	J:147582
Biological Process	GO:1904263	positive regulation of TORC1 signaling	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	IBA	J:265628
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	IMP	J:173708
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:154667
Biological Process	GO:0032465	regulation of cytokinesis	ISO	J:164563
Biological Process	GO:2000973	regulation of pro-B cell differentiation	IMP	J:189078
Biological Process	GO:0001932	regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0046578	regulation of Ras protein signal transduction	ISO	J:164563
Biological Process	GO:0032006	regulation of TOR signaling	IMP	J:161878
Biological Process	GO:0031929	TOR signaling	ISO	J:164563
Biological Process	GO:0031929	TOR signaling	IMP	J:147582
Biological Process	GO:0031929	TOR signaling	IMP	J:173708
Biological Process	GO:0031929	TOR signaling	IMP	J:130978
Biological Process	GO:0031929	TOR signaling	IMP	J:130978
Biological Process	GO:0031929	TOR signaling	IMP	J:143922
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IMP	J:173708