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GO Annotations Graph
Symbol
Name
ID
Tirap
toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
MGI:2152213

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005546phosphatidylinositol-4,5-bisphosphate bindingIDAJ:171185
Molecular FunctionGO:0005515protein bindingIPIJ:71392
Molecular FunctionGO:0005515protein bindingIPIJ:180126
Molecular FunctionGO:0005515protein bindingIPIJ:169794
Molecular FunctionGO:0046982protein heterodimerization activityISOJ:164563
Molecular FunctionGO:0046982protein heterodimerization activityIDAJ:71392
Molecular FunctionGO:0042803protein homodimerization activityIDAJ:71392
Molecular FunctionGO:0005080protein kinase C bindingISOJ:164563
Molecular FunctionGO:0035663Toll-like receptor 2 bindingISOJ:164563
Molecular FunctionGO:0035663Toll-like receptor 2 bindingIPIJ:169893
Molecular FunctionGO:0035662Toll-like receptor 4 bindingISOJ:164563
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0030139endocytic vesicleIDAJ:171185
Cellular ComponentGO:0045171intercellular bridgeISOJ:164563
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0005654nucleoplasmISOJ:164563
Cellular ComponentGO:0005886plasma membraneISOJ:164563
Cellular ComponentGO:0032587ruffle membraneIDAJ:171185
Biological ProcessGO:00709353'-UTR-mediated mRNA stabilizationISOJ:164563
Biological ProcessGO:0007257activation of JUN kinase activityISOJ:71392
Biological ProcessGO:0007166cell surface receptor signaling pathwayIPIJ:72250
Biological ProcessGO:0007166cell surface receptor signaling pathwayISOJ:71392
Biological ProcessGO:0071221cellular response to bacterial lipopeptideIMPJ:96018
Biological ProcessGO:0071223cellular response to lipoteichoic acidIMPJ:96018
Biological ProcessGO:0050830defense response to Gram-positive bacteriumIMPJ:96018
Biological ProcessGO:0007249I-kappaB kinase/NF-kappaB signalingIMPJ:72250
Biological ProcessGO:0007249I-kappaB kinase/NF-kappaB signalingISOJ:71392
Biological ProcessGO:0002376immune system processIEAJ:60000
Biological ProcessGO:0006954inflammatory responseIEAJ:60000
Biological ProcessGO:0045087innate immune responseIEAJ:60000
Biological ProcessGO:0030099myeloid cell differentiationIMPJ:72250
Biological ProcessGO:0044130negative regulation of growth of symbiont in hostIMPJ:96018
Biological ProcessGO:0030890positive regulation of B cell proliferationIMPJ:96773
Biological ProcessGO:2000340positive regulation of chemokine (C-X-C motif) ligand 1 productionIMPJ:122157
Biological ProcessGO:2000343positive regulation of chemokine (C-X-C motif) ligand 2 productionIMPJ:122157
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeISOJ:164563
Biological ProcessGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingISOJ:164563
Biological ProcessGO:0045089positive regulation of innate immune responseIMPJ:122157
Biological ProcessGO:0032735positive regulation of interleukin-12 productionIMPJ:96773
Biological ProcessGO:0032738positive regulation of interleukin-15 productionISOJ:164563
Biological ProcessGO:0045410positive regulation of interleukin-6 biosynthetic processIMPJ:96773
Biological ProcessGO:0045410positive regulation of interleukin-6 biosynthetic processIDAJ:169799
Biological ProcessGO:0045410positive regulation of interleukin-6 biosynthetic processISOJ:164563
Biological ProcessGO:0045410positive regulation of interleukin-6 biosynthetic processIMPJ:122157
Biological ProcessGO:0045410positive regulation of interleukin-6 biosynthetic processIMPJ:169893
Biological ProcessGO:0032757positive regulation of interleukin-8 productionISOJ:164563
Biological ProcessGO:0032757positive regulation of interleukin-8 productionIMPJ:122157
Biological ProcessGO:0046330positive regulation of JNK cascadeISOJ:164563
Biological ProcessGO:0090023positive regulation of neutrophil chemotaxisIMPJ:169888
Biological ProcessGO:0051092positive regulation of NF-kappaB transcription factor activityISOJ:164563
Biological ProcessGO:0051092positive regulation of NF-kappaB transcription factor activityIMPJ:96773
Biological ProcessGO:0090073positive regulation of protein homodimerization activityISOJ:164563
Biological ProcessGO:0034137positive regulation of toll-like receptor 2 signaling pathwayISOJ:164563
Biological ProcessGO:0034141positive regulation of toll-like receptor 3 signaling pathwayIDAJ:169893
Biological ProcessGO:0034145positive regulation of toll-like receptor 4 signaling pathwayISOJ:164563
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionIMPJ:122157
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionISOJ:164563
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionIMPJ:96018
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionIMPJ:96773
Biological ProcessGO:0045088regulation of innate immune responseNASJ:96773
Biological ProcessGO:0032648regulation of interferon-beta productionIDAJ:169792
Biological ProcessGO:0032658regulation of interleukin-15 productionIMPJ:169880
Biological ProcessGO:0009617response to bacteriumISOJ:71392
Biological ProcessGO:0032496response to lipopolysaccharideISOJ:164563
Biological ProcessGO:0007165signal transductionIEAJ:72247
Biological ProcessGO:0035665TIRAP-dependent toll-like receptor 4 signaling pathwayISOJ:164563


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory