GO Annotations Graph

• Symbol: Ldlrap1
• Name: low density lipoprotein receptor adaptor protein 1
• ID: MGI:2140175

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	IPI	J:126870
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:164563
Molecular Function	GO:0035650	AP-1 adaptor complex binding	ISO	J:164563
Molecular Function	GO:0035612	AP-2 adaptor complex binding	ISO	J:164563
Molecular Function	GO:0035615	clathrin adaptor activity	ISO	J:164563
Molecular Function	GO:0030276	clathrin binding	ISO	J:164563
Molecular Function	GO:0030276	clathrin binding	ISO	J:80188
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	ISO	J:164563
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISO	J:164563
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:126870
Molecular Function	GO:0005515	protein binding	IPI	J:84694
Molecular Function	GO:0035591	signaling adaptor activity	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:80188
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0009925	basal plasma membrane	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:126870
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005769	early endosome	IBA	J:265628
Cellular Component	GO:0005769	early endosome	IDA	J:84694
Cellular Component	GO:0005883	neurofilament	IDA	J:126870
Cellular Component	GO:0055037	recycling endosome	ISO	J:164563
Biological Process	GO:0042982	amyloid precursor protein metabolic process	ISO	J:164563
Biological Process	GO:0071345	cellular response to cytokine stimulus	ISO	J:164563
Biological Process	GO:0042632	cholesterol homeostasis	ISO	J:164563
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:84694
Biological Process	GO:0008203	cholesterol metabolic process	IEA	J:60000
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0034383	low-density lipoprotein particle clearance	ISO	J:164563
Biological Process	GO:1905581	positive regulation of low-density lipoprotein particle clearance	ISO	J:164563
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	ISO	J:164563
Biological Process	GO:1905602	positive regulation of receptor-mediated endocytosis involved in cholesterol transport	ISO	J:164563
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0031623	receptor internalization	ISO	J:164563
Biological Process	GO:0006898	receptor-mediated endocytosis	ISO	J:164563
Biological Process	GO:0090118	receptor-mediated endocytosis involved in cholesterol transport	ISO	J:164563
Biological Process	GO:0043393	regulation of protein binding	ISO	J:164563
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000