GO Annotations Graph

• Symbol: Dpyd
• Name: dihydropyrimidine dehydrogenase
• ID: MGI:2139667

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051539	4 iron, 4 sulfur cluster binding	IEA	J:60000
Molecular Function	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	ISO	J:155856
Molecular Function	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	ISO	J:164563
Molecular Function	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	IBA	J:265628
Molecular Function	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	IDA	J:5178
Molecular Function	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	IDA	J:5178
Molecular Function	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	ISO	J:21749
Molecular Function	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	IDA	J:5178
Molecular Function	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	IDA	J:5178
Molecular Function	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	IDA	J:83143
Molecular Function	GO:0071949	FAD binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0005506	iron ion binding	ISO	J:155856
Molecular Function	GO:0051536	iron-sulfur cluster binding	IEA	J:60000
Molecular Function	GO:0051536	iron-sulfur cluster binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0050661	NADP binding	ISO	J:155856
Molecular Function	GO:0050661	NADP binding	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	IEA	J:72247
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:155856
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0002058	uracil binding	ISO	J:155856
Molecular Function	GO:0002058	uracil binding	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:5178
Cellular Component	GO:0005829	cytosol	IDA	J:5178
Cellular Component	GO:0005829	cytosol	IDA	J:83143
Cellular Component	GO:0005829	cytosol	IDA	J:83143
Biological Process	GO:0007623	circadian rhythm	ISO	J:155856
Biological Process	GO:0006248	CMP catabolic process	IDA	J:5178
Biological Process	GO:0006249	dCMP catabolic process	IDA	J:5178
Biological Process	GO:0046074	dTMP catabolic process	ISO	J:21749
Biological Process	GO:0046079	dUMP catabolic process	IDA	J:5178
Biological Process	GO:0006145	purine nucleobase catabolic process	ISO	J:164563
Biological Process	GO:0006208	pyrimidine nucleobase catabolic process	ISO	J:155856
Biological Process	GO:0006208	pyrimidine nucleobase catabolic process	ISO	J:164563
Biological Process	GO:0006208	pyrimidine nucleobase catabolic process	IDA	J:83143
Biological Process	GO:0007584	response to nutrient	ISO	J:155856
Biological Process	GO:0014070	response to organic cyclic compound	ISO	J:155856
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0006214	thymidine catabolic process	ISO	J:164563
Biological Process	GO:0006210	thymine catabolic process	ISO	J:164563
Biological Process	GO:0006210	thymine catabolic process	IBA	J:265628
Biological Process	GO:0046050	UMP catabolic process	IDA	J:5178
Biological Process	GO:0006212	uracil catabolic process	ISO	J:164563
Biological Process	GO:0006212	uracil catabolic process	IBA	J:265628
Biological Process	GO:0019860	uracil metabolic process	ISO	J:155856