GO Annotations Graph

• Symbol: Slc12a6
• Name: solute carrier family 12, member 6
• ID: MGI:2135960

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008519	ammonium transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0015079	potassium ion transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0015379	potassium:chloride symporter activity	IDA	J:55435
Molecular Function	GO:0015379	potassium:chloride symporter activity	ISO	J:164563
Molecular Function	GO:0015379	potassium:chloride symporter activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:80982
Molecular Function	GO:0005515	protein binding	IPI	J:80982
Molecular Function	GO:0019901	protein kinase binding	IPI	J:278187
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Cellular Component	GO:0030424	axon	IDA	J:76182
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:175181
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:76182
Cellular Component	GO:0005886	plasma membrane	IDA	J:55435
Biological Process	GO:0140157	ammonium import across plasma membrane	ISO	J:164563
Biological Process	GO:0006884	cell volume homeostasis	IBA	J:265628
Biological Process	GO:0071476	cellular hypotonic response	ISO	J:164563
Biological Process	GO:0071477	cellular hypotonic salinity response	ISO	J:164563
Biological Process	GO:0071333	cellular response to glucose stimulus	IDA	J:202948
Biological Process	GO:0007268	chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0055064	chloride ion homeostasis	IDA	J:55435
Biological Process	GO:0055064	chloride ion homeostasis	IBA	J:265628
Biological Process	GO:1902476	chloride transmembrane transport	IBA	J:265628
Biological Process	GO:0006811	monoatomic ion transport	ISO	J:164563
Biological Process	GO:0055075	potassium ion homeostasis	IDA	J:55435
Biological Process	GO:0055075	potassium ion homeostasis	IBA	J:265628
Biological Process	GO:1990573	potassium ion import across plasma membrane	ISO	J:164563
Biological Process	GO:1990573	potassium ion import across plasma membrane	IBA	J:265628
Biological Process	GO:0071805	potassium ion transmembrane transport	ISO	J:164563