GO Annotations Graph

• Symbol: Kars1
• Name: lysyl-tRNA synthetase 1
• ID: MGI:1934754

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016597	amino acid binding	ISO	J:155856
Molecular Function	GO:0004812	aminoacyl-tRNA ligase activity	IEA	J:60000
Molecular Function	GO:0004812	aminoacyl-tRNA ligase activity	IEA	J:72247
Molecular Function	GO:0003877	ATP adenylyltransferase activity	ISO	J:164563
Molecular Function	GO:0003877	ATP adenylyltransferase activity	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016874	ligase activity	IEA	J:60000
Molecular Function	GO:0004824	lysine-tRNA ligase activity	ISO	J:164563
Molecular Function	GO:0004824	lysine-tRNA ligase activity	ISO	J:155856
Molecular Function	GO:0004824	lysine-tRNA ligase activity	IBA	J:265628
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0097110	scaffold protein binding	IPI	J:93041
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0000049	tRNA binding	ISO	J:164563
Molecular Function	GO:0000049	tRNA binding	ISO	J:155856
Molecular Function	GO:0000049	tRNA binding	IBA	J:265628
Cellular Component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	ISO	J:164563
Cellular Component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	IDA	J:93041
Cellular Component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	ISO	J:155856
Cellular Component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0002276	basophil activation involved in immune response	ISO	J:164563
Biological Process	GO:0002276	basophil activation involved in immune response	ISO	J:155856
Biological Process	GO:0002276	basophil activation involved in immune response	IBA	J:265628
Biological Process	GO:0015966	diadenosine tetraphosphate biosynthetic process	ISO	J:155856
Biological Process	GO:0015966	diadenosine tetraphosphate biosynthetic process	ISO	J:164563
Biological Process	GO:0015966	diadenosine tetraphosphate biosynthetic process	IBA	J:265628
Biological Process	GO:0070371	ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0070371	ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0006430	lysyl-tRNA aminoacylation	ISO	J:164563
Biological Process	GO:0006430	lysyl-tRNA aminoacylation	ISO	J:155856
Biological Process	GO:0006430	lysyl-tRNA aminoacylation	IBA	J:265628
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0002863	positive regulation of inflammatory response to antigenic stimulus	ISO	J:164563
Biological Process	GO:0043032	positive regulation of macrophage activation	ISO	J:164563
Biological Process	GO:0043032	positive regulation of macrophage activation	IBA	J:265628
Biological Process	GO:0010165	response to X-ray	ISO	J:155856
Biological Process	GO:0006412	translation	IEA	J:60000
Biological Process	GO:0006418	tRNA aminoacylation for protein translation	IEA	J:72247