About   Help   FAQ
GO Annotations Graph
Symbol
Name
ID
Ern1
endoplasmic reticulum (ER) to nucleus signalling 1
MGI:1930134

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0043531ADP bindingISOJ:164563
Molecular FunctionGO:0005524ATP bindingISOJ:164563
Molecular FunctionGO:0016443bidentate ribonuclease III activityIEAJ:72245
Molecular FunctionGO:0003824catalytic activityIEAJ:60000
Molecular FunctionGO:0004519endonuclease activityIDAJ:107824
Molecular FunctionGO:0004521endoribonuclease activityIDAJ:95320
Molecular FunctionGO:0004521endoribonuclease activityISOJ:164563
Molecular FunctionGO:0019899enzyme bindingISOJ:164563
Molecular FunctionGO:0030544Hsp70 protein bindingISOJ:164563
Molecular FunctionGO:0051879Hsp90 protein bindingISOJ:164563
Molecular FunctionGO:0051879Hsp90 protein bindingISOJ:155856
Molecular FunctionGO:0016787hydrolase activityIEAJ:60000
Molecular FunctionGO:0042802identical protein bindingISOJ:164563
Molecular FunctionGO:0016301kinase activityIEAJ:60000
Molecular FunctionGO:0000287magnesium ion bindingISOJ:164563
Molecular FunctionGO:0046872metal ion bindingIEAJ:60000
Molecular FunctionGO:0000166nucleotide bindingIEAJ:60000
Molecular FunctionGO:0005515protein bindingIPIJ:136554
Molecular FunctionGO:0005515protein bindingIPIJ:200442
Molecular FunctionGO:0005515protein bindingIPIJ:145150
Molecular FunctionGO:0005515protein bindingIPIJ:147348
Molecular FunctionGO:0005515protein bindingIPIJ:201886
Molecular FunctionGO:0042803protein homodimerization activityISOJ:164563
Molecular FunctionGO:0004672protein kinase activityIEAJ:72247
Molecular FunctionGO:0004674protein serine/threonine kinase activityISOJ:164563
Molecular FunctionGO:0004540ribonuclease activityIEAJ:72247
Molecular FunctionGO:0016740transferase activityIEAJ:60000
Cellular ComponentGO:1990597AIP1-IRE1 complexIPIJ:136554
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0005783endoplasmic reticulumISOJ:164563
Cellular ComponentGO:0005789endoplasmic reticulum membraneIDAJ:57921
Cellular ComponentGO:0030176integral component of endoplasmic reticulum membraneISOJ:164563
Cellular ComponentGO:0016021integral component of membraneIEAJ:60000
Cellular ComponentGO:1990630IRE1-RACK1-PP2A complexISOJ:164563
Cellular ComponentGO:1990604IRE1-TRAF2-ASK1 complexISOJ:164563
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0005739mitochondrionIDAJ:192731
Cellular ComponentGO:0005637nuclear inner membraneIDAJ:107824
Biological ProcessGO:0007257activation of JUN kinase activityISOJ:164563
Biological ProcessGO:0007257activation of JUN kinase activityIMPJ:132966
Biological ProcessGO:0006987activation of signaling protein activity involved in unfolded protein responseISOJ:164563
Biological ProcessGO:0006915apoptotic processIEAJ:60000
Biological ProcessGO:0007050cell cycle arrestIDAJ:66969
Biological ProcessGO:0071333cellular response to glucose stimulusISOJ:164563
Biological ProcessGO:0035924cellular response to vascular endothelial growth factor stimulusISOJ:164563
Biological ProcessGO:0030968endoplasmic reticulum unfolded protein responseIDAJ:62257
Biological ProcessGO:0030968endoplasmic reticulum unfolded protein responseIDAJ:70005
Biological ProcessGO:0030968endoplasmic reticulum unfolded protein responseIDAJ:95320
Biological ProcessGO:0001935endothelial cell proliferationISOJ:164563
Biological ProcessGO:1901142insulin metabolic processISOJ:164563
Biological ProcessGO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIDAJ:66969
Biological ProcessGO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIMPJ:147348
Biological ProcessGO:0036498IRE1-mediated unfolded protein responseISOJ:164563
Biological ProcessGO:0008152metabolic processIEAJ:60000
Biological ProcessGO:0006379mRNA cleavageISOJ:164563
Biological ProcessGO:0070055mRNA endonucleolytic cleavage involved in unfolded protein responseISOJ:164563
Biological ProcessGO:0006397mRNA processingIEAJ:72247
Biological ProcessGO:0070054mRNA splicing, via endonucleolytic cleavage and ligationISOJ:164563
Biological ProcessGO:0036289peptidyl-serine autophosphorylationISOJ:164563
Biological ProcessGO:1990579peptidyl-serine trans-autophosphorylationISOJ:164563
Biological ProcessGO:0016310phosphorylationIEAJ:60000
Biological ProcessGO:1900103positive regulation of endoplasmic reticulum unfolded protein responseISOJ:164563
Biological ProcessGO:0033120positive regulation of RNA splicingISOJ:164563
Biological ProcessGO:0046777protein autophosphorylationIDAJ:70005
Biological ProcessGO:0046777protein autophosphorylationISOJ:164563
Biological ProcessGO:0006468protein phosphorylationISOJ:164563
Biological ProcessGO:0006355regulation of transcription, DNA-templatedIEAJ:60000
Biological ProcessGO:0034976response to endoplasmic reticulum stressISOJ:164563
Biological ProcessGO:0006986response to unfolded proteinIEAJ:60000
Biological ProcessGO:0090502RNA phosphodiester bond hydrolysis, endonucleolyticISOJ:164563
Biological ProcessGO:0006351transcription, DNA-templatedIEAJ:60000


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/13/2022
MGI 6.21
The Jackson Laboratory