Shank3 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Shank3
SH3 and multiple ankyrin repeat domains 3
MGI:1930016

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IEA	J:60000
Molecular Function	GO:0001664	G protein-coupled receptor binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	IPI	J:108736
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	IPI	J:150922
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:251297
Molecular Function	GO:0005515	protein binding	IPI	J:249721
Molecular Function	GO:0005515	protein binding	IPI	J:249721
Molecular Function	GO:0005515	protein binding	IPI	J:314369
Molecular Function	GO:0005515	protein binding	IPI	J:245377
Molecular Function	GO:0005515	protein binding	IPI	J:281389
Molecular Function	GO:0005515	protein binding	IPI	J:281389
Molecular Function	GO:0005515	protein binding	IPI	J:108736
Molecular Function	GO:0005515	protein binding	IPI	J:249721
Molecular Function	GO:0005515	protein binding	IPI	J:251297
Molecular Function	GO:0005515	protein binding	IPI	J:280803
Molecular Function	GO:0005515	protein binding	IPI	J:94527
Molecular Function	GO:0005515	protein binding	IPI	J:94527
Molecular Function	GO:0043621	protein self-association	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	IPI	J:108736
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:155856
Molecular Function	GO:0098919	structural constituent of postsynaptic density	ISO	J:155856
Molecular Function	GO:0098919	structural constituent of postsynaptic density	IDA	J:235641
Molecular Function	GO:0098919	structural constituent of postsynaptic density	IDA	J:235641
Molecular Function	GO:0098919	structural constituent of postsynaptic density	IEP	J:235641
Molecular Function	GO:0098919	structural constituent of postsynaptic density	IMP	J:235641
Molecular Function	GO:0098919	structural constituent of postsynaptic density	IDA	J:235641
Molecular Function	GO:0030160	synaptic receptor adaptor activity	ISO	J:155856
Molecular Function	GO:0030160	synaptic receptor adaptor activity	IBA	J:265628
Molecular Function	GO:0008270	zinc ion binding	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0060170	ciliary membrane	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0043197	dendritic spine	IBA	J:265628
Cellular Component	GO:0060076	excitatory synapse	IC	J:171113
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:235641
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:235641
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:235641
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:235641
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:235641
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:235641
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:235641
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:235641
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:235641
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:235641
Cellular Component	GO:0043005	neuron projection	IDA	J:184110
Cellular Component	GO:0044309	neuron spine	IDA	J:108736
Cellular Component	GO:0005886	plasma membrane	IDA	J:108736
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IBA	J:265628
Cellular Component	GO:0099092	postsynaptic density, intracellular component	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	IBA	J:265628
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0030534	adult behavior	ISO	J:164563
Biological Process	GO:0097113	AMPA glutamate receptor clustering	IMP	J:184110
Biological Process	GO:0097113	AMPA glutamate receptor clustering	IMP	J:184110
Biological Process	GO:0097113	AMPA glutamate receptor clustering	IMP	J:173402
Biological Process	GO:0008306	associative learning	IMP	J:225991
Biological Process	GO:0048854	brain morphogenesis	IMP	J:171113
Biological Process	GO:0060997	dendritic spine morphogenesis	IMP	J:171113
Biological Process	GO:0060997	dendritic spine morphogenesis	IMP	J:175320
Biological Process	GO:0060997	dendritic spine morphogenesis	IMP	J:173402
Biological Process	GO:0001838	embryonic epithelial tube formation	IGI	J:94527
Biological Process	GO:0035640	exploration behavior	IMP	J:173402
Biological Process	GO:0010467	gene expression	IMP	J:266519
Biological Process	GO:0014009	glial cell proliferation	IMP	J:237767
Biological Process	GO:0097117	guanylate kinase-associated protein clustering	IMP	J:173402
Biological Process	GO:0007612	learning	ISO	J:164563
Biological Process	GO:0007612	learning	IMP	J:173402
Biological Process	GO:0007611	learning or memory	IMP	J:173402
Biological Process	GO:0040011	locomotion	IMP	J:173402
Biological Process	GO:0007626	locomotory behavior	IMP	J:173402
Biological Process	GO:0035641	locomotory exploration behavior	IMP	J:171113
Biological Process	GO:0035641	locomotory exploration behavior	IMP	J:173402
Biological Process	GO:0060292	long-term synaptic depression	IMP	J:184110
Biological Process	GO:0060291	long-term synaptic potentiation	IMP	J:173402
Biological Process	GO:0000165	MAPK cascade	IGI	J:94527
Biological Process	GO:0000165	MAPK cascade	IGI	J:94527
Biological Process	GO:0007613	memory	IMP	J:173402
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:235641
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IEP	J:235641
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:235641
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:235641
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:235641
Biological Process	GO:0032232	negative regulation of actin filament bundle assembly	IDA	J:148808
Biological Process	GO:0045794	negative regulation of cell volume	IMP	J:171113
Biological Process	GO:0061351	neural precursor cell proliferation	IMP	J:237767
Biological Process	GO:0050885	neuromuscular process controlling balance	IMP	J:173402
Biological Process	GO:0097114	NMDA glutamate receptor clustering	IMP	J:173402
Biological Process	GO:2000969	positive regulation of AMPA receptor activity	IMP	J:171113
Biological Process	GO:0060999	positive regulation of dendritic spine development	IMP	J:184110
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	IMP	J:184110
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	IMP	J:171113
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	IMP	J:175320
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	IMP	J:184110
Biological Process	GO:1900451	positive regulation of glutamate receptor signaling pathway	ISO	J:155856
Biological Process	GO:1900451	positive regulation of glutamate receptor signaling pathway	IMP	J:184110
Biological Process	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	IMP	J:175320
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	IMP	J:175320
Biological Process	GO:0051835	positive regulation of synapse structural plasticity	IMP	J:175320
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	IMP	J:175320
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	IMP	J:184110
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	IMP	J:171113
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	IMP	J:184110
Biological Process	GO:0097107	postsynaptic density assembly	IMP	J:171113
Biological Process	GO:1904717	regulation of AMPA glutamate receptor clustering	IMP	J:173402
Biological Process	GO:2000822	regulation of behavioral fear response	IMP	J:171113
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis	IMP	J:184110
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis	IMP	J:184110
Biological Process	GO:2000821	regulation of grooming behavior	IMP	J:173402
Biological Process	GO:2000821	regulation of grooming behavior	IMP	J:171113
Biological Process	GO:1900452	regulation of long-term synaptic depression	IMP	J:184110
Biological Process	GO:1900271	regulation of long-term synaptic potentiation	IMP	J:173402
Biological Process	GO:0099175	regulation of postsynapse organization	ISO	J:155856
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:173402
Biological Process	GO:0097396	response to interleukin-17	IMP	J:289937
Biological Process	GO:0035176	social behavior	IMP	J:175320
Biological Process	GO:0035176	social behavior	ISO	J:164563
Biological Process	GO:0035176	social behavior	IMP	J:171113
Biological Process	GO:0035176	social behavior	IMP	J:289937
Biological Process	GO:0035176	social behavior	IMP	J:289937
Biological Process	GO:0035176	social behavior	IMP	J:289937
Biological Process	GO:0035176	social behavior	IMP	J:173402
Biological Process	GO:0021773	striatal medium spiny neuron differentiation	IMP	J:171113
Biological Process	GO:0007416	synapse assembly	IMP	J:171113
Biological Process	GO:0042297	vocal learning	ISO	J:164563
Biological Process	GO:0071625	vocalization behavior	IMP	J:175320
Biological Process	GO:0071625	vocalization behavior	ISO	J:164563
Biological Process	GO:0071625	vocalization behavior	IMP	J:173402

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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