GO Annotations Graph

• Symbol: Ace2
• Name: angiotensin converting enzyme 2
• ID: MGI:1917258

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004180	carboxypeptidase activity	ISO	J:164563
Molecular Function	GO:0004180	carboxypeptidase activity	ISO	J:155856
Molecular Function	GO:0004180	carboxypeptidase activity	TAS	J:77232
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004181	metallocarboxypeptidase activity	ISO	J:164563
Molecular Function	GO:0008237	metallopeptidase activity	ISO	J:164563
Molecular Function	GO:0008237	metallopeptidase activity	IBA	J:265628
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:313957
Molecular Function	GO:0005515	protein binding	IPI	J:146850
Molecular Function	GO:0005515	protein binding	IPI	J:314372
Molecular Function	GO:0001618	virus receptor activity	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0031526	brush border membrane	ISO	J:164563
Cellular Component	GO:0031526	brush border membrane	IDA	J:146850
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:213091
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:213091
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0003051	angiotensin-mediated drinking behavior	ISO	J:164563
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:2000272	negative regulation of signaling receptor activity	ISO	J:164563
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0051957	positive regulation of amino acid transport	ISO	J:164563
Biological Process	GO:0060452	positive regulation of cardiac muscle contraction	IMP	J:77232
Biological Process	GO:1903598	positive regulation of gap junction assembly	ISO	J:164563
Biological Process	GO:1905737	positive regulation of L-proline import across plasma membrane	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IEA	J:72247
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0046813	receptor-mediated virion attachment to host cell	ISO	J:164563
Biological Process	GO:1903779	regulation of cardiac conduction	ISO	J:164563
Biological Process	GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	ISO	J:164563
Biological Process	GO:0022898	regulation of transmembrane transporter activity	ISO	J:164563
Biological Process	GO:0015827	tryptophan transport	IMP	J:186775
Biological Process	GO:0046718	viral entry into host cell	ISO	J:164563