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GO Annotations Graph
Symbol
Name
ID
Lrrk2
leucine-rich repeat kinase 2
MGI:1913975

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0003779actin bindingISOJ:164563
Molecular FunctionGO:0005524ATP bindingIEAJ:72247
Molecular FunctionGO:0005524ATP bindingIEAJ:60000
Molecular FunctionGO:1904713beta-catenin destruction complex bindingIPIJ:188340
Molecular FunctionGO:0030276clathrin bindingISOJ:164563
Molecular FunctionGO:0001948glycoprotein bindingISOJ:164563
Molecular FunctionGO:0005525GTP bindingISAJ:113152
Molecular FunctionGO:0005525GTP bindingISOJ:164563
Molecular FunctionGO:0034211GTP-dependent protein kinase activityISOJ:164563
Molecular FunctionGO:0034211GTP-dependent protein kinase activityISAJ:113152
Molecular FunctionGO:0005096GTPase activator activityISOJ:164563
Molecular FunctionGO:0003924GTPase activityISOJ:164563
Molecular FunctionGO:0042802identical protein bindingIPIJ:196255
Molecular FunctionGO:0042802identical protein bindingISOJ:164563
Molecular FunctionGO:0042802identical protein bindingIPIJ:196230
Molecular FunctionGO:0044325ion channel bindingISOJ:164563
Molecular FunctionGO:0016301kinase activityISOJ:164563
Molecular FunctionGO:0004708MAP kinase kinase activityISOJ:164563
Molecular FunctionGO:0000166nucleotide bindingIEAJ:60000
Molecular FunctionGO:0036479peroxidase inhibitor activityISOJ:164563
Molecular FunctionGO:0005515protein bindingIPIJ:183203
Molecular FunctionGO:0005515protein bindingIPIJ:213877
Molecular FunctionGO:0005515protein bindingIPIJ:188340
Molecular FunctionGO:0005515protein bindingIPIJ:183409
Molecular FunctionGO:0005515protein bindingIPIJ:188340
Molecular FunctionGO:0005515protein bindingIPIJ:183238
Molecular FunctionGO:0005515protein bindingIPIJ:209576
Molecular FunctionGO:0005515protein bindingIPIJ:196255
Molecular FunctionGO:0005515protein bindingIPIJ:206832
Molecular FunctionGO:0005515protein bindingIPIJ:169453
Molecular FunctionGO:0005515protein bindingIPIJ:186257
Molecular FunctionGO:0005515protein bindingIPIJ:204661
Molecular FunctionGO:0005515protein bindingIPIJ:206826
Molecular FunctionGO:0042803protein homodimerization activityISOJ:164563
Molecular FunctionGO:0051018protein kinase A bindingISOJ:164563
Molecular FunctionGO:0051018protein kinase A bindingIPIJ:206832
Molecular FunctionGO:0004672protein kinase activityIDAJ:206826
Molecular FunctionGO:0004672protein kinase activityISOJ:164563
Molecular FunctionGO:0004674protein serine/threonine kinase activityISOJ:73065
Molecular FunctionGO:0030159receptor signaling complex scaffold activityICJ:188340
Molecular FunctionGO:0017048Rho GTPase bindingIPIJ:183203
Molecular FunctionGO:0017048Rho GTPase bindingISOJ:164563
Molecular FunctionGO:0000149SNARE bindingISOJ:164563
Molecular FunctionGO:0017075syntaxin-1 bindingISOJ:164563
Molecular FunctionGO:0016740transferase activityIEAJ:60000
Molecular FunctionGO:0015631tubulin bindingISOJ:164563
Cellular ComponentGO:0044753amphisomeISOJ:164563
Cellular ComponentGO:0044754autolysosomeISOJ:164563
Cellular ComponentGO:0030424axonISOJ:155856
Cellular ComponentGO:0030424axonISOJ:164563
Cellular ComponentGO:0005901caveolaISOJ:164563
Cellular ComponentGO:0030054cell junctionIEAJ:60000
Cellular ComponentGO:0042995cell projectionIEAJ:60000
Cellular ComponentGO:0005737cytoplasmISOJ:155856
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0032473cytoplasmic side of mitochondrial outer membraneISOJ:164563
Cellular ComponentGO:0031410cytoplasmic vesicleIDAJ:210913
Cellular ComponentGO:0005829cytosolISOJ:164563
Cellular ComponentGO:0030425dendriteISOJ:164563
Cellular ComponentGO:0030425dendriteISOJ:155856
Cellular ComponentGO:0030425dendriteIDAJ:206832
Cellular ComponentGO:0032839dendrite cytoplasmISOJ:164563
Cellular ComponentGO:0005783endoplasmic reticulumISOJ:164563
Cellular ComponentGO:0005783endoplasmic reticulumIDAJ:210913
Cellular ComponentGO:0005768endosomeIDAJ:210913
Cellular ComponentGO:0070062extracellular exosomeISOJ:164563
Cellular ComponentGO:0005615extracellular spaceISOJ:164563
Cellular ComponentGO:0005794Golgi apparatusIDAJ:210913
Cellular ComponentGO:0005798Golgi-associated vesicleISOJ:164563
Cellular ComponentGO:0030426growth coneISOJ:164563
Cellular ComponentGO:0016234inclusion bodyISOJ:164563
Cellular ComponentGO:0005622intracellularISOJ:164563
Cellular ComponentGO:0043231intracellular membrane-bounded organelleISOJ:155856
Cellular ComponentGO:0030529intracellular ribonucleoprotein complexIDAJ:211935
Cellular ComponentGO:0005764lysosomeIDAJ:210913
Cellular ComponentGO:0016020membraneISOJ:155856
Cellular ComponentGO:0045121membrane raftIDAJ:121772
Cellular ComponentGO:0005902microvillusISOJ:164563
Cellular ComponentGO:0005743mitochondrial inner membraneIDAJ:210913
Cellular ComponentGO:0005759mitochondrial matrixIDAJ:210913
Cellular ComponentGO:0031966mitochondrial membraneISOJ:164563
Cellular ComponentGO:0005741mitochondrial outer membraneIDAJ:210913
Cellular ComponentGO:0005739mitochondrionISOJ:164563
Cellular ComponentGO:0097487multivesicular body, internal vesicleISOJ:164563
Cellular ComponentGO:0043005neuron projectionISOJ:164563
Cellular ComponentGO:0043005neuron projectionISOJ:155856
Cellular ComponentGO:0043025neuronal cell bodyISOJ:164563
Cellular ComponentGO:0043204perikaryonISOJ:164563
Cellular ComponentGO:0043204perikaryonISOJ:155856
Cellular ComponentGO:0005886plasma membraneISOJ:164563
Cellular ComponentGO:0005886plasma membraneIDAJ:121772
Cellular ComponentGO:0045202synapseIDAJ:183238
Cellular ComponentGO:0008021synaptic vesicleIDAJ:121772
Cellular ComponentGO:0043195terminal boutonICJ:169453
Cellular ComponentGO:0005802trans-Golgi networkIDAJ:206826
Cellular ComponentGO:0005802trans-Golgi networkIDAJ:121772
Cellular ComponentGO:1990909Wnt signalosomeISOJ:164563
Cellular ComponentGO:1990909Wnt signalosomeIDAJ:188340
Biological ProcessGO:0000187activation of MAPK activityISOJ:164563
Biological ProcessGO:0000186activation of MAPKK activityISOJ:164563
Biological ProcessGO:0006914autophagyIEAJ:60000
Biological ProcessGO:0019722calcium-mediated signalingISOJ:164563
Biological ProcessGO:0030154cell differentiationIEAJ:60000
Biological ProcessGO:0034613cellular protein localizationIMPJ:206832
Biological ProcessGO:1903351cellular response to dopamineISOJ:164563
Biological ProcessGO:0071287cellular response to manganese ionISOJ:164563
Biological ProcessGO:0034599cellular response to oxidative stressISOJ:164563
Biological ProcessGO:0009267cellular response to starvationISOJ:164563
Biological ProcessGO:0008340determination of adult lifespanISOJ:164563
Biological ProcessGO:0006897endocytosisISOJ:164563
Biological ProcessGO:0060079excitatory postsynaptic potentialIMPJ:206832
Biological ProcessGO:0035640exploration behaviorISOJ:164563
Biological ProcessGO:0007030Golgi organizationISOJ:164563
Biological ProcessGO:0007030Golgi organizationIGIJ:206826
Biological ProcessGO:0046039GTP metabolic processISOJ:164563
Biological ProcessGO:0048312intracellular distribution of mitochondriaISOJ:164563
Biological ProcessGO:0035556intracellular signal transductionIMPJ:206832
Biological ProcessGO:0035641locomotory exploration behaviorIMPJ:206832
Biological ProcessGO:0007040lysosome organizationISOJ:164563
Biological ProcessGO:0000165MAPK cascadeISOJ:164563
Biological ProcessGO:0051646mitochondrion localizationISOJ:164563
Biological ProcessGO:0007005mitochondrion organizationISOJ:164563
Biological ProcessGO:1902902negative regulation of autophagosome assemblyISOJ:164563
Biological ProcessGO:1902236negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayISOJ:164563
Biological ProcessGO:0090394negative regulation of excitatory postsynaptic potentialIMPJ:169453
Biological ProcessGO:0034260negative regulation of GTPase activityISOJ:183238
Biological ProcessGO:1903206negative regulation of hydrogen peroxide-induced cell deathISOJ:164563
Biological ProcessGO:0016242negative regulation of macroautophagyISOJ:164563
Biological ProcessGO:1901215negative regulation of neuron deathISOJ:164563
Biological ProcessGO:2000469negative regulation of peroxidase activityISOJ:164563
Biological ProcessGO:0032091negative regulation of protein bindingISOJ:164563
Biological ProcessGO:0001933negative regulation of protein phosphorylationIMPJ:206832
Biological ProcessGO:0010955negative regulation of protein processingISOJ:164563
Biological ProcessGO:1903215negative regulation of protein targeting to mitochondrionISOJ:164563
Biological ProcessGO:1903125negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylationISOJ:164563
Biological ProcessGO:0007528neuromuscular junction developmentISOJ:164563
Biological ProcessGO:0070997neuron deathISOJ:164563
Biological ProcessGO:0048812neuron projection morphogenesisISOJ:164563
Biological ProcessGO:0021772olfactory bulb developmentISOJ:164563
Biological ProcessGO:0018105peptidyl-serine phosphorylationISOJ:164563
Biological ProcessGO:0018107peptidyl-threonine phosphorylationISOJ:164563
Biological ProcessGO:0016310phosphorylationISOJ:164563
Biological ProcessGO:0010508positive regulation of autophagyISOJ:164563
Biological ProcessGO:0010508positive regulation of autophagyIMPJ:160542
Biological ProcessGO:0090263positive regulation of canonical Wnt signaling pathwayISOJ:164563
Biological ProcessGO:0060161positive regulation of dopamine receptor signaling pathwayISOJ:164563
Biological ProcessGO:0043547positive regulation of GTPase activityISOJ:164563
Biological ProcessGO:0043068positive regulation of programmed cell deathISOJ:164563
Biological ProcessGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic processIMPJ:160542
Biological ProcessGO:1902499positive regulation of protein autoubiquitinationISOJ:164563
Biological ProcessGO:0032092positive regulation of protein bindingISOJ:164563
Biological ProcessGO:0001934positive regulation of protein phosphorylationISOJ:164563
Biological ProcessGO:0031398positive regulation of protein ubiquitinationISOJ:164563
Biological ProcessGO:0046777protein autophosphorylationISOJ:164563
Biological ProcessGO:0046777protein autophosphorylationISAJ:113152
Biological ProcessGO:0006468protein phosphorylationISOJ:164563
Biological ProcessGO:0006468protein phosphorylationISAJ:113152
Biological ProcessGO:0072593reactive oxygen species metabolic processISOJ:164563
Biological ProcessGO:0010506regulation of autophagyISOJ:164563
Biological ProcessGO:2000172regulation of branching morphogenesis of a nerveISOJ:164563
Biological ProcessGO:1903169regulation of calcium ion transmembrane transportISOJ:164563
Biological ProcessGO:0060828regulation of canonical Wnt signaling pathwayIPIJ:188340
Biological ProcessGO:0061001regulation of dendritic spine morphogenesisIGIJ:206832
Biological ProcessGO:0061001regulation of dendritic spine morphogenesisISOJ:164563
Biological ProcessGO:0060159regulation of dopamine receptor signaling pathwayIMPJ:206832
Biological ProcessGO:0035564regulation of kidney sizeIMPJ:160542
Biological ProcessGO:0040012regulation of locomotionISOJ:164563
Biological ProcessGO:0035751regulation of lysosomal lumen pHISOJ:164563
Biological ProcessGO:0042391regulation of membrane potentialISOJ:164563
Biological ProcessGO:0051900regulation of mitochondrial depolarizationISOJ:164563
Biological ProcessGO:1902692regulation of neuroblast proliferationISOJ:164563
Biological ProcessGO:1901214regulation of neuron deathISOJ:164563
Biological ProcessGO:0014041regulation of neuron maturationISOJ:164563
Biological ProcessGO:0010738regulation of protein kinase A signalingIMPJ:206832
Biological ProcessGO:0051966regulation of synaptic transmission, glutamatergicIMPJ:206832
Biological ProcessGO:2000300regulation of synaptic vesicle exocytosisISOJ:164563
Biological ProcessGO:1902803regulation of synaptic vesicle transportIMPJ:169453
Biological ProcessGO:0006979response to oxidative stressISOJ:164563
Biological ProcessGO:0007264small GTPase mediated signal transductionIEAJ:72247
Biological ProcessGO:0036465synaptic vesicle recyclingTASJ:169453
Biological ProcessGO:0022028tangential migration from the subventricular zone to the olfactory bulbISOJ:164563
Biological ProcessGO:1904887Wnt signalosome assemblyISOJ:164563
Biological ProcessGO:1904887Wnt signalosome assemblyICJ:188340


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory