GO Annotations Graph

• Symbol: Fgf23
• Name: fibroblast growth factor 23
• ID: MGI:1891427

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005104	fibroblast growth factor receptor binding	IPI	J:110570
Molecular Function	GO:0005104	fibroblast growth factor receptor binding	IPI	J:110570
Molecular Function	GO:0008083	growth factor activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:117479
Molecular Function	GO:0005105	type 1 fibroblast growth factor receptor binding	IPI	J:117479
Molecular Function	GO:0005105	type 1 fibroblast growth factor receptor binding	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:206158
Biological Process	GO:0009887	animal organ morphogenesis	IBA	J:265628
Biological Process	GO:0055074	calcium ion homeostasis	IDA	J:201223
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IDA	J:201223
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IPI	J:110570
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IPI	J:110570
Biological Process	GO:0030643	intracellular phosphate ion homeostasis	IMP	J:94041
Biological Process	GO:0000165	MAPK cascade	IDA	J:206158
Biological Process	GO:0030502	negative regulation of bone mineralization	ISO	J:164563
Biological Process	GO:0046888	negative regulation of hormone secretion	ISO	J:155856
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0055062	phosphate ion homeostasis	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:117479
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:117479
Biological Process	GO:0010628	positive regulation of gene expression	IBA	J:265628
Biological Process	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	IGI	J:110570
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IBA	J:265628
Biological Process	GO:0010980	positive regulation of vitamin D 24-hydroxylase activity	ISO	J:164563
Biological Process	GO:0030500	regulation of bone mineralization	IMP	J:94041
Biological Process	GO:0030334	regulation of cell migration	IBA	J:265628
Biological Process	GO:0010966	regulation of phosphate transport	ISO	J:164563
Biological Process	GO:1904383	response to sodium phosphate	IDA	J:201223
Biological Process	GO:0042369	vitamin D catabolic process	ISO	J:164563