GO Annotations Graph

• Symbol: Nphs1
• Name: nephrosis 1, nephrin
• ID: MGI:1859637

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051393	alpha-actinin binding	ISO	J:155856
Molecular Function	GO:0050839	cell adhesion molecule binding	IBA	J:265628
Molecular Function	GO:0017022	myosin binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:171732
Molecular Function	GO:0005515	protein binding	IPI	J:73142
Molecular Function	GO:0005515	protein binding	IPI	J:140017
Molecular Function	GO:0005515	protein binding	IPI	J:99306
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0030507	spectrin binding	ISO	J:155856
Cellular Component	GO:0005604	basement membrane	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IDA	J:168261
Cellular Component	GO:0005911	cell-cell junction	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005925	focal adhesion	IDA	J:254431
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	TAS	J:73142
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-451756
Cellular Component	GO:0005886	plasma membrane	IDA	J:99306
Cellular Component	GO:0005886	plasma membrane	TAS	J:73411
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0036057	slit diaphragm	ISO	J:155856
Biological Process	GO:0007155	cell adhesion	IGI	J:171732
Biological Process	GO:0007155	cell adhesion	IGI	J:171732
Biological Process	GO:0098609	cell-cell adhesion	IBA	J:265628
Biological Process	GO:0007254	JNK cascade	IDA	J:73411
Biological Process	GO:0000165	MAPK cascade	IDA	J:73411
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0007517	muscle organ development	IEA	J:60000
Biological Process	GO:0007520	myoblast fusion	IMP	J:150083
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IGI	J:128987
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IGI	J:128987
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IGI	J:128987
Biological Process	GO:0035418	protein localization to synapse	ISO	J:164563
Biological Process	GO:0007519	skeletal muscle tissue development	IMP	J:150083
Biological Process	GO:0036060	slit diaphragm assembly	IMP	J:66970