GO Annotations Graph

• Symbol: Il27ra
• Name: interleukin 27 receptor, alpha
• ID: MGI:1355318

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019955	cytokine binding	IBA	J:265628
Molecular Function	GO:0045509	interleukin-27 receptor activity	IBA	J:265628
Molecular Function	GO:0045509	interleukin-27 receptor activity	IDA	J:77522
Molecular Function	GO:0005515	protein binding	IPI	J:77522
Molecular Function	GO:0005515	protein binding	IPI	J:77522
Cellular Component	GO:0005737	cytoplasm	TAS	Reactome:R-MMU-8950729
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-8950729
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-8950409
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:65439
Biological Process	GO:0002692	negative regulation of cellular extravasation	IGI	J:212625
Biological Process	GO:0032700	negative regulation of interleukin-17 production	IGI	J:212625
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IGI	J:212625
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:2000408	negative regulation of T cell extravasation	IGI	J:212625
Biological Process	GO:2000317	negative regulation of T-helper 17 type immune response	IGI	J:212625
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IGI	J:212625
Biological Process	GO:0002829	negative regulation of type 2 immune response	IMP	J:65439
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response	IMP	J:65439
Biological Process	GO:0032729	positive regulation of type II interferon production	IMP	J:65439
Biological Process	GO:0048302	regulation of isotype switching to IgG isotypes	IMP	J:65439