GO Annotations Graph

• Symbol: Trpm2
• Name: transient receptor potential cation channel, subfamily M, member 2
• ID: MGI:1351901

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0047631	ADP-ribose diphosphatase activity	IEA	J:72247
Molecular Function	GO:0005262	calcium channel activity	IEA	J:60000
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0015278	calcium-release channel activity	ISO	J:164563
Molecular Function	GO:0099604	ligand-gated calcium channel activity	ISO	J:164563
Molecular Function	GO:0099604	ligand-gated calcium channel activity	IMP	J:178425
Molecular Function	GO:0099604	ligand-gated calcium channel activity	IBA	J:265628
Molecular Function	GO:0005384	manganese ion transmembrane transporter activity	IDA	J:137259
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0072571	mono-ADP-D-ribose binding	ISO	J:164563
Molecular Function	GO:0005261	monoatomic cation channel activity	ISO	J:164563
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0005272	sodium channel activity	IEA	J:60000
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	IDA	J:178425
Cellular Component	GO:0005765	lysosomal membrane	IDA	J:178425
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:178425
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:137259
Biological Process	GO:0098703	calcium ion import across plasma membrane	IMP	J:178425
Biological Process	GO:0098703	calcium ion import across plasma membrane	ISO	J:155856
Biological Process	GO:0097553	calcium ion transmembrane import into cytosol	ISO	J:164563
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	IEA	J:60000
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	IMP	J:178425
Biological Process	GO:0071277	cellular response to calcium ion	ISO	J:164563
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:164563
Biological Process	GO:0071415	cellular response to purine-containing compound	IMP	J:178425
Biological Process	GO:0071502	cellular response to temperature stimulus	IMP	J:235274
Biological Process	GO:0002407	dendritic cell chemotaxis	IMP	J:178425
Biological Process	GO:0097028	dendritic cell differentiation	IMP	J:178425
Biological Process	GO:0006828	manganese ion transport	IDA	J:137259
Biological Process	GO:0006812	monoatomic cation transport	IEA	J:72247
Biological Process	GO:0034220	monoatomic ion transmembrane transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0032024	positive regulation of insulin secretion	ISO	J:155856
Biological Process	GO:1903223	positive regulation of oxidative stress-induced neuron death	ISO	J:155856
Biological Process	GO:0051289	protein homotetramerization	ISO	J:164563
Biological Process	GO:2000249	regulation of actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0051489	regulation of filopodium assembly	ISO	J:164563
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IMP	J:178425
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IBA	J:265628
Biological Process	GO:0009408	response to heat	IMP	J:235274
Biological Process	GO:0033194	response to hydroperoxide	IDA	J:137259
Biological Process	GO:0006979	response to oxidative stress	IEA	J:72247
Biological Process	GO:0014074	response to purine-containing compound	ISO	J:164563
Biological Process	GO:0006814	sodium ion transport	IEA	J:60000
Biological Process	GO:0001659	temperature homeostasis	IMP	J:235274
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247
Biological Process	GO:0071577	zinc ion transmembrane transport	ISO	J:164563