Map3k7 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Map3k7
mitogen-activated protein kinase kinase kinase 7
MGI:1346877

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:1990450	linear polyubiquitin binding	ISO	J:164563
Molecular Function	GO:0000287	magnesium ion binding	IEA	J:72247
Molecular Function	GO:0004707	MAP kinase activity	ISO	J:164563
Molecular Function	GO:0004708	MAP kinase kinase activity	IDA	J:80766
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	ISO	J:164563
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	ISO	J:155856
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	IBA	J:265628
Molecular Function	GO:0008349	MAP kinase kinase kinase kinase activity	IMP	J:163789
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:236517
Molecular Function	GO:0005515	protein binding	IPI	J:150837
Molecular Function	GO:0005515	protein binding	IPI	J:279494
Molecular Function	GO:0005515	protein binding	IPI	J:148055
Molecular Function	GO:0005515	protein binding	IPI	J:201312
Molecular Function	GO:0005515	protein binding	IPI	J:206842
Molecular Function	GO:0005515	protein binding	IPI	J:120934
Molecular Function	GO:0005515	protein binding	IPI	J:259108
Molecular Function	GO:0005515	protein binding	IPI	J:245318
Molecular Function	GO:0005515	protein binding	IPI	J:179005
Molecular Function	GO:0005515	protein binding	IPI	J:166091
Molecular Function	GO:0005515	protein binding	IPI	J:84524
Molecular Function	GO:0005515	protein binding	IPI	J:208236
Molecular Function	GO:0005515	protein binding	IPI	J:84524
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:259108
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-MMU-209329
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0030971	receptor tyrosine kinase binding	IPI	J:259108
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:205449
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0140672	ATAC complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-209329
Cellular Component	GO:0008385	IkappaB kinase complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0014069	postsynaptic density	IDA	J:187362
Biological Process	GO:0007250	activation of NF-kappaB-inducing kinase activity	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IMP	J:107401
Biological Process	GO:0043276	anoikis	IMP	J:238448
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0097190	apoptotic signaling pathway	IGI	J:102721
Biological Process	GO:0097190	apoptotic signaling pathway	IMP	J:102721
Biological Process	GO:0060348	bone development	IMP	J:163789
Biological Process	GO:0043966	histone H3 acetylation	ISO	J:164563
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IGI	J:102721
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IGI	J:102721
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IGI	J:102721
Biological Process	GO:0007252	I-kappaB phosphorylation	ISO	J:164563
Biological Process	GO:0007252	I-kappaB phosphorylation	IGI	J:102721
Biological Process	GO:0007252	I-kappaB phosphorylation	IGI	J:102721
Biological Process	GO:0038173	interleukin-17A-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0007254	JNK cascade	IDA	J:262344
Biological Process	GO:0007254	JNK cascade	ISO	J:164563
Biological Process	GO:0007254	JNK cascade	IBA	J:265628
Biological Process	GO:0007254	JNK cascade	IGI	J:102721
Biological Process	GO:0007254	JNK cascade	IGI	J:102721
Biological Process	GO:0007254	JNK cascade	IGI	J:102721
Biological Process	GO:0000165	MAPK cascade	ISO	J:164563
Biological Process	GO:0000165	MAPK cascade	ISO	J:155856
Biological Process	GO:0000165	MAPK cascade	IMP	J:163789
Biological Process	GO:0000165	MAPK cascade	IDA	J:84524
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	IGI	J:102721
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	IMP	J:102721
Biological Process	GO:0060546	negative regulation of necroptotic process	IMP	J:182381
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	IMP	J:182381
Biological Process	GO:1902443	negative regulation of ripoptosome assembly involved in necroptotic process	IGI	J:182381
Biological Process	GO:1902443	negative regulation of ripoptosome assembly involved in necroptotic process	IGI	J:182381
Biological Process	GO:0001841	neural tube formation	IMP	J:102721
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:163789
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IDA	J:259108
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:155856
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IGI	J:102721
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IGI	J:102721
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IGI	J:102721
Biological Process	GO:0032743	positive regulation of interleukin-2 production	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	IGI	J:102721
Biological Process	GO:0046330	positive regulation of JNK cascade	IGI	J:102721
Biological Process	GO:0046330	positive regulation of JNK cascade	IGI	J:102721
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:164563
Biological Process	GO:0016239	positive regulation of macroautophagy	IMP	J:238448
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0002726	positive regulation of T cell cytokine production	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IDA	J:251915
Biological Process	GO:0006468	protein phosphorylation	IDA	J:80766
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	IMP	J:182381
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0051403	stress-activated MAPK cascade	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IMP	J:102271

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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