GO Annotations Graph

• Symbol: Map2k1
• Name: mitogen-activated protein kinase kinase 1
• ID: MGI:1346866

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004708	MAP kinase kinase activity	ISO	J:155856
Molecular Function	GO:0004708	MAP kinase kinase activity	ISO	J:164563
Molecular Function	GO:0004708	MAP kinase kinase activity	IBA	J:265628
Molecular Function	GO:0004708	MAP kinase kinase activity	IDA	J:25190
Molecular Function	GO:0004708	MAP kinase kinase activity	IDA	J:25190
Molecular Function	GO:0004708	MAP kinase kinase activity	IMP	J:75391
Molecular Function	GO:0005078	MAP-kinase scaffold activity	ISO	J:164563
Molecular Function	GO:0031435	mitogen-activated protein kinase kinase kinase binding	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:210622
Molecular Function	GO:0005515	protein binding	IPI	J:64817
Molecular Function	GO:0005515	protein binding	IPI	J:175345
Molecular Function	GO:0005515	protein binding	ISO	J:187529
Molecular Function	GO:0030295	protein kinase activator activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	ISO	J:164563
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	IDA	J:25190
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	IDA	J:25190
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0004712	protein serine/threonine/tyrosine kinase activity	TAS	J:180564
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:60000
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0005938	cell cortex	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	J:180564
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-451681
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0032839	dendrite cytoplasm	ISO	J:155856
Cellular Component	GO:0005769	early endosome	TAS	J:180564
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:187529
Cellular Component	GO:0005925	focal adhesion	TAS	J:180564
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	TAS	J:180564
Cellular Component	GO:0005770	late endosome	TAS	J:180564
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005874	microtubule	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	TAS	J:180564
Cellular Component	GO:0005634	nucleus	TAS	J:180564
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Biological Process	GO:0060020	Bergmann glial cell differentiation	IGI	J:205567
Biological Process	GO:0048870	cell motility	IMP	J:54197
Biological Process	GO:0008283	cell population proliferation	ISO	J:155856
Biological Process	GO:0090398	cellular senescence	ISO	J:164563
Biological Process	GO:0021697	cerebellar cortex formation	IGI	J:205567
Biological Process	GO:0035987	endodermal cell differentiation	IDA	J:114676
Biological Process	GO:0060502	epithelial cell proliferation involved in lung morphogenesis	IGI	J:214083
Biological Process	GO:0060502	epithelial cell proliferation involved in lung morphogenesis	IGI	J:214083
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IGI	J:214083
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IGI	J:214083
Biological Process	GO:0060324	face development	IGI	J:144862
Biological Process	GO:0042593	glucose homeostasis	ISO	J:155856
Biological Process	GO:0048313	Golgi inheritance	ISO	J:155856
Biological Process	GO:0007507	heart development	IGI	J:144862
Biological Process	GO:0008286	insulin receptor signaling pathway	ISO	J:326634
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IMP	J:327220
Biological Process	GO:0030216	keratinocyte differentiation	IMP	J:75391
Biological Process	GO:0060711	labyrinthine layer development	IMP	J:54197
Biological Process	GO:0060425	lung morphogenesis	IGI	J:214083
Biological Process	GO:0000165	MAPK cascade	IBA	J:265628
Biological Process	GO:0032402	melanosome transport	ISO	J:155856
Biological Process	GO:0000278	mitotic cell cycle	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0034111	negative regulation of homotypic cell-cell adhesion	ISO	J:155856
Biological Process	GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:0030182	neuron differentiation	ISO	J:155856
Biological Process	GO:0030182	neuron differentiation	IBA	J:265628
Biological Process	GO:0030182	neuron differentiation	IMP	J:91751
Biological Process	GO:0048812	neuron projection morphogenesis	ISO	J:155856
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0060674	placenta blood vessel development	IMP	J:54197
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	ISO	J:155856
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:155856
Biological Process	GO:0050772	positive regulation of axonogenesis	IGI	J:213126
Biological Process	GO:0050772	positive regulation of axonogenesis	IGI	J:213126
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:1903226	positive regulation of endodermal cell differentiation	IDA	J:114676
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:98599
Biological Process	GO:0045933	positive regulation of muscle contraction	ISO	J:155856
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	ISO	J:145554
Biological Process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IMP	J:98599
Biological Process	GO:0006468	protein phosphorylation	IGI	J:143745
Biological Process	GO:0048679	regulation of axon regeneration	IGI	J:213126
Biological Process	GO:0048679	regulation of axon regeneration	IGI	J:213126
Biological Process	GO:2000641	regulation of early endosome to late endosome transport	TAS	J:180564
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0090170	regulation of Golgi inheritance	TAS	J:180564
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO	J:155856
Biological Process	GO:0032872	regulation of stress-activated MAPK cascade	TAS	J:180564
Biological Process	GO:0003056	regulation of vascular associated smooth muscle contraction	ISO	J:155856
Biological Process	GO:0048678	response to axon injury	ISO	J:155856
Biological Process	GO:0051384	response to glucocorticoid	ISO	J:155856
Biological Process	GO:0006979	response to oxidative stress	ISO	J:155856
Biological Process	GO:0048538	thymus development	IGI	J:144862
Biological Process	GO:0030878	thyroid gland development	IGI	J:144862
Biological Process	GO:0060440	trachea formation	IGI	J:214083
Biological Process	GO:0070328	triglyceride homeostasis	ISO	J:155856
Biological Process	GO:0044342	type B pancreatic cell proliferation	IMP	J:326637
Biological Process	GO:0047496	vesicle transport along microtubule	ISO	J:155856