GO Annotations Graph

• Symbol: Mapk8
• Name: mitogen-activated protein kinase 8
• ID: MGI:1346861

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0008047	enzyme activator activity	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0035033	histone deacetylase regulator activity	ISO	J:164563
Molecular Function	GO:0004705	JUN kinase activity	ISO	J:164563
Molecular Function	GO:0004705	JUN kinase activity	IDA	J:61895
Molecular Function	GO:0004705	JUN kinase activity	ISO	J:155856
Molecular Function	GO:0004705	JUN kinase activity	IBA	J:265628
Molecular Function	GO:0004705	JUN kinase activity	IDA	J:148987
Molecular Function	GO:0004705	JUN kinase activity	IDA	J:96879
Molecular Function	GO:0016301	kinase activity	IDA	J:97560
Molecular Function	GO:0016301	kinase activity	IDA	J:97170
Molecular Function	GO:0016301	kinase activity	IDA	J:83953
Molecular Function	GO:0019894	kinesin binding	ISO	J:155856
Molecular Function	GO:0004707	MAP kinase activity	IEA	J:72247
Molecular Function	GO:0004707	MAP kinase activity	IEA	J:72245
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:77616
Molecular Function	GO:0005515	protein binding	IPI	J:172900
Molecular Function	GO:0005515	protein binding	IPI	J:66310
Molecular Function	GO:0005515	protein binding	IPI	J:64817
Molecular Function	GO:0005515	protein binding	IPI	J:200416
Molecular Function	GO:0005515	protein binding	IPI	J:95350
Molecular Function	GO:0005515	protein binding	IPI	J:97170
Molecular Function	GO:0005515	protein binding	IPI	J:230002
Molecular Function	GO:0005515	protein binding	IPI	J:57455
Molecular Function	GO:0004672	protein kinase activity	IDA	J:230002
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:251887
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:211909
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:230002
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:73065
Molecular Function	GO:0120283	protein serine/threonine kinase binding	ISO	J:164563
Molecular Function	GO:0004712	protein serine/threonine/tyrosine kinase activity	IMP	J:259122
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IMP	J:191610
Cellular Component	GO:0097441	basal dendrite	IMP	J:191610
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IMP	J:259122
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:211909
Cellular Component	GO:0005737	cytoplasm	IDA	J:90586
Cellular Component	GO:0005737	cytoplasm	IDA	J:249035
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-205060
Cellular Component	GO:0005829	cytosol	IDA	J:131696
Cellular Component	GO:0032839	dendrite cytoplasm	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IDA	J:131696
Cellular Component	GO:0043005	neuron projection	IDA	J:249035
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:211909
Cellular Component	GO:0005634	nucleus	IDA	J:97170
Cellular Component	GO:0005634	nucleus	IDA	J:90586
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0002102	podosome	IDA	J:211909
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:118605
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:118605
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0031982	vesicle	ISO	J:155856
Biological Process	GO:0097190	apoptotic signaling pathway	IGI	J:106899
Biological Process	GO:0034198	cellular response to amino acid starvation	ISO	J:164563
Biological Process	GO:0071216	cellular response to biotic stimulus	IMP	J:199058
Biological Process	GO:0071276	cellular response to cadmium ion	ISO	J:164563
Biological Process	GO:0070301	cellular response to hydrogen peroxide	IDA	J:198334
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:205449
Biological Process	GO:0071732	cellular response to nitric oxide	IMP	J:146389
Biological Process	GO:0034599	cellular response to oxidative stress	ISO	J:164563
Biological Process	GO:0034614	cellular response to reactive oxygen species	ISO	J:164563
Biological Process	GO:0048813	dendrite morphogenesis	IMP	J:99429
Biological Process	GO:0048263	determination of dorsal identity	ISO	J:137475
Biological Process	GO:0006954	inflammatory response	ISO	J:155856
Biological Process	GO:0007254	JNK cascade	ISO	J:164563
Biological Process	GO:0007254	JNK cascade	IDA	J:61895
Biological Process	GO:0007254	JNK cascade	IBA	J:265628
Biological Process	GO:0007254	JNK cascade	ISO	J:137475
Biological Process	GO:0007258	JUN phosphorylation	ISO	J:73065
Biological Process	GO:0007258	JUN phosphorylation	IMP	J:88294
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:118605
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:118605
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:73065
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:164563
Biological Process	GO:0001764	neuron migration	IMP	J:170348
Biological Process	GO:0031175	neuron projection development	ISO	J:155856
Biological Process	GO:0097150	neuronal stem cell population maintenance	ISO	J:73065
Biological Process	GO:0001503	ossification	IMP	J:97303
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:259122
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:230002
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IMP	J:88294
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	IBA	J:265628
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	IGI	J:106899
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0031281	positive regulation of cyclase activity	ISO	J:164563
Biological Process	GO:0090045	positive regulation of deacetylase activity	ISO	J:164563
Biological Process	GO:2000017	positive regulation of determination of dorsal identity	IDA	J:137089
Biological Process	GO:0045740	positive regulation of DNA replication	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0034352	positive regulation of glial cell apoptotic process	ISO	J:155856
Biological Process	GO:0031116	positive regulation of microtubule polymerization	ISO	J:155856
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	ISO	J:155856
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:2001224	positive regulation of neuron migration	ISO	J:155856
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	IDA	J:251887
Biological Process	GO:0071803	positive regulation of podosome assembly	IMP	J:211909
Biological Process	GO:0051247	positive regulation of protein metabolic process	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	IMP	J:259122
Biological Process	GO:1901485	positive regulation of transcription factor catabolic process	IMP	J:259122
Biological Process	GO:0097300	programmed necrotic cell death	IMP	J:146389
Biological Process	GO:0061833	protein localization to tricellular tight junction	IMP	J:230002
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IMP	J:186089
Biological Process	GO:0006468	protein phosphorylation	IDA	J:230002
Biological Process	GO:0006468	protein phosphorylation	IDA	J:97560
Biological Process	GO:0046605	regulation of centrosome cycle	ISO	J:155856
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:186089
Biological Process	GO:1904809	regulation of dense core granule transport	ISO	J:155856
Biological Process	GO:1902595	regulation of DNA replication origin binding	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0010468	regulation of gene expression	IMP	J:148987
Biological Process	GO:0045664	regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0032880	regulation of protein localization	ISO	J:164563
Biological Process	GO:0046686	response to cadmium ion	IGI	J:106899
Biological Process	GO:0009408	response to heat	ISO	J:155856
Biological Process	GO:0042542	response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:0009612	response to mechanical stimulus	IBA	J:265628
Biological Process	GO:0006970	response to osmotic stress	ISO	J:155856
Biological Process	GO:0006979	response to oxidative stress	ISO	J:164563
Biological Process	GO:0009411	response to UV	ISO	J:73065
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0007165	signal transduction	ISO	J:155856
Biological Process	GO:0051403	stress-activated MAPK cascade	ISO	J:164563
Biological Process	GO:0097050	type B pancreatic cell apoptotic process	ISO	J:155856