GO Annotations Graph

• Symbol: Tlr1
• Name: toll-like receptor 1
• ID: MGI:1341295

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0071723	lipopeptide binding	ISO	J:155856
Molecular Function	GO:0071723	lipopeptide binding	IBA	J:265628
Molecular Function	GO:0038023	signaling receptor activity	IBA	J:265628
Molecular Function	GO:0035663	Toll-like receptor 2 binding	ISO	J:164563
Molecular Function	GO:0035663	Toll-like receptor 2 binding	IBA	J:265628
Molecular Function	GO:0004888	transmembrane signaling receptor activity	NAS	J:114793
Molecular Function	GO:0042497	triacyl lipopeptide binding	NAS	J:103395
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	NAS	J:114793
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0045335	phagocytic vesicle	NAS	J:82453
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Cellular Component	GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex	IBA	J:265628
Cellular Component	GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex	ISO	J:73065
Biological Process	GO:0007250	activation of NF-kappaB-inducing kinase activity	NAS	J:103395
Biological Process	GO:0071727	cellular response to triacyl bacterial lipopeptide	IBA	J:265628
Biological Process	GO:0071727	cellular response to triacyl bacterial lipopeptide	ISO	J:73065
Biological Process	GO:0006952	defense response	IMP	J:95726
Biological Process	GO:0042495	detection of triacyl bacterial lipopeptide	NAS	J:103395
Biological Process	GO:0042495	detection of triacyl bacterial lipopeptide	ISO	J:73065
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0042116	macrophage activation	NAS	J:82453
Biological Process	GO:0001774	microglial cell activation	ISO	J:155856
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	IEA	J:72247
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:103395
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0034137	positive regulation of toll-like receptor 2 signaling pathway	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:103395
Biological Process	GO:0001817	regulation of cytokine production	IEA	J:72247
Biological Process	GO:0032493	response to bacterial lipoprotein	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0034130	toll-like receptor 1 signaling pathway	IEA	J:72247
Biological Process	GO:0002224	toll-like receptor signaling pathway	ISO	J:155856
Biological Process	GO:0002224	toll-like receptor signaling pathway	ISO	J:164563
Biological Process	GO:0002224	toll-like receptor signaling pathway	IBA	J:265628