GO Annotations Graph

• Symbol: Acvr1b
• Name: activin A receptor, type 1B
• ID: MGI:1338944

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048185	activin binding	ISO	J:164563
Molecular Function	GO:0048185	activin binding	IBA	J:265628
Molecular Function	GO:0048185	activin binding	IPI	J:27756
Molecular Function	GO:0017002	activin receptor activity	ISO	J:164563
Molecular Function	GO:0016361	activin receptor activity, type I	ISO	J:164563
Molecular Function	GO:0016361	activin receptor activity, type I	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0019838	growth factor binding	ISO	J:164563
Molecular Function	GO:0034711	inhibin binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:140377
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:140377
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0046332	SMAD binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	TAS	J:46637
Cellular Component	GO:0048179	activin receptor complex	ISO	J:164563
Cellular Component	GO:0048179	activin receptor complex	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1225898
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	TAS	J:46637
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Biological Process	GO:0032924	activin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0032924	activin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0032924	activin receptor signaling pathway	IDA	J:106894
Biological Process	GO:0060936	cardiac fibroblast cell development	ISO	J:155856
Biological Process	GO:0007166	cell surface receptor signaling pathway	TAS	J:46637
Biological Process	GO:0071363	cellular response to growth factor stimulus	IBA	J:265628
Biological Process	GO:0009790	embryo development	IMP	J:46637
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0001942	hair follicle development	IMP	J:100691
Biological Process	GO:0001701	in utero embryonic development	IMP	J:94135
Biological Process	GO:0001701	in utero embryonic development	IMP	J:108723
Biological Process	GO:0007498	mesoderm development	ISO	J:37683
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:191209
Biological Process	GO:0007399	nervous system development	IBA	J:265628
Biological Process	GO:0038092	nodal signaling pathway	ISO	J:164563
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IDA	J:140377
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0032927	positive regulation of activin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:191209
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:1901165	positive regulation of trophoblast cell migration	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0009966	regulation of signal transduction	IDA	J:127541
Biological Process	GO:0007165	signal transduction	ISO	J:164563
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	IEA	J:72247