GO Annotations Graph

• Symbol: Pikfyve
• Name: phosphoinositide kinase, FYVE type zinc finger containing
• ID: MGI:1335106

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	ISO	J:164563
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	IDA	J:292524
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	IDA	J:292526
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	IDA	J:135218
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	TAS	Reactome:R-NUL-1675886
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	TAS	Reactome:R-NUL-1675925
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	TAS	Reactome:R-NUL-1675982
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	IBA	J:265628
Molecular Function	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	IDA	J:51612
Molecular Function	GO:0052810	1-phosphatidylinositol-5-kinase activity	ISO	J:164563
Molecular Function	GO:0052810	1-phosphatidylinositol-5-kinase activity	IDA	J:135218
Molecular Function	GO:0052810	1-phosphatidylinositol-5-kinase activity	IDA	J:292526
Molecular Function	GO:0052810	1-phosphatidylinositol-5-kinase activity	IDA	J:292524
Molecular Function	GO:0052810	1-phosphatidylinositol-5-kinase activity	TAS	Reactome:R-NUL-1676051
Molecular Function	GO:0052810	1-phosphatidylinositol-5-kinase activity	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0016301	kinase activity	IDA	J:292523
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0016307	phosphatidylinositol phosphate kinase activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:137431
Molecular Function	GO:0005515	protein binding	IPI	J:292523
Molecular Function	GO:0005515	protein binding	IPI	J:147603
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:292526
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0008270	zinc ion binding	IDA	J:51612
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0031410	cytoplasmic vesicle	IBA	J:265628
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:135217
Cellular Component	GO:0005829	cytosol	IDA	J:135217
Cellular Component	GO:0031901	early endosome membrane	ISO	J:164563
Cellular Component	GO:0031901	early endosome membrane	TAS	Reactome:R-NUL-1675886
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0010008	endosome membrane	ISO	J:164563
Cellular Component	GO:0000139	Golgi membrane	TAS	Reactome:R-NUL-1675982
Cellular Component	GO:0031902	late endosome membrane	TAS	Reactome:R-NUL-1675925
Cellular Component	GO:0031902	late endosome membrane	TAS	Reactome:R-NUL-1676051
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:147603
Cellular Component	GO:0030670	phagocytic vesicle membrane	ISO	J:164563
Cellular Component	GO:0012506	vesicle membrane	IDA	J:51612
Cellular Component	GO:0012506	vesicle membrane	IBA	J:265628
Biological Process	GO:1903100	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process	IDA	J:292526
Biological Process	GO:1903100	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process	IDA	J:292524
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:51612
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0032438	melanosome organization	IMP	J:262141
Biological Process	GO:0032438	melanosome organization	ISO	J:164563
Biological Process	GO:0032438	melanosome organization	IBA	J:265628
Biological Process	GO:0032288	myelin assembly	IGI	J:177998
Biological Process	GO:0030593	neutrophil chemotaxis	ISO	J:164563
Biological Process	GO:0030593	neutrophil chemotaxis	IDA	J:251375
Biological Process	GO:0030593	neutrophil chemotaxis	IBA	J:265628
Biological Process	GO:0036289	peptidyl-serine autophosphorylation	IDA	J:292526
Biological Process	GO:0090382	phagosome maturation	IDA	J:289081
Biological Process	GO:0090382	phagosome maturation	ISO	J:164563
Biological Process	GO:0090385	phagosome-lysosome fusion	ISO	J:164563
Biological Process	GO:0090385	phagosome-lysosome fusion	IDA	J:251375
Biological Process	GO:0090385	phagosome-lysosome fusion	IBA	J:265628
Biological Process	GO:1904562	phosphatidylinositol 5-phosphate metabolic process	IDA	J:292524
Biological Process	GO:1904562	phosphatidylinositol 5-phosphate metabolic process	IDA	J:292526
Biological Process	GO:0046488	phosphatidylinositol metabolic process	IEA	J:72247
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0034504	protein localization to nucleus	ISO	J:164563
Biological Process	GO:0006612	protein targeting to membrane	IDA	J:292523
Biological Process	GO:0019065	receptor-mediated endocytosis of virus by host cell	ISO	J:164563
Biological Process	GO:2000785	regulation of autophagosome assembly	ISO	J:164563
Biological Process	GO:1903426	regulation of reactive oxygen species biosynthetic process	ISO	J:164563
Biological Process	GO:1903426	regulation of reactive oxygen species biosynthetic process	IDA	J:251375
Biological Process	GO:1903426	regulation of reactive oxygen species biosynthetic process	IBA	J:265628
Biological Process	GO:0042147	retrograde transport, endosome to Golgi	ISO	J:164563