Trex1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Trex1
three prime repair exonuclease 1
MGI:1328317

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008408	3'-5' exonuclease activity	ISO	J:164563
Molecular Function	GO:0008408	3'-5' exonuclease activity	IMP	J:92264
Molecular Function	GO:0008296	3'-5'-DNA exonuclease activity	IDA	J:197521
Molecular Function	GO:0008296	3'-5'-DNA exonuclease activity	ISO	J:164563
Molecular Function	GO:0008296	3'-5'-DNA exonuclease activity	IBA	J:265628
Molecular Function	GO:0032558	adenyl deoxyribonucleotide binding	IDA	J:121158
Molecular Function	GO:0003677	DNA binding	IDA	J:166550
Molecular Function	GO:0008301	DNA binding, bending	IDA	J:220965
Molecular Function	GO:0008311	double-stranded DNA 3'-5' DNA exonuclease activity	ISO	J:164563
Molecular Function	GO:0003690	double-stranded DNA binding	IDA	J:220965
Molecular Function	GO:0003690	double-stranded DNA binding	IDA	J:145965
Molecular Function	GO:0004527	exonuclease activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	IPI	J:121158
Molecular Function	GO:0000287	magnesium ion binding	IDA	J:220965
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:164563
Molecular Function	GO:0032405	MutLalpha complex binding	ISO	J:111285
Molecular Function	GO:0032407	MutSalpha complex binding	ISO	J:111285
Molecular Function	GO:0004518	nuclease activity	IEA	J:60000
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:197521
Molecular Function	GO:0005515	protein binding	IPI	J:197521
Molecular Function	GO:0005515	protein binding	IPI	J:145466
Molecular Function	GO:0042803	protein homodimerization activity	IPI	J:197521
Molecular Function	GO:0003697	single-stranded DNA binding	IDA	J:122553
Molecular Function	GO:0003697	single-stranded DNA binding	IDA	J:121158
Molecular Function	GO:0050699	WW domain binding	IDA	J:122553
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:173423
Cellular Component	GO:0005737	cytoplasm	IDA	J:122553
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:243357
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:233654
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:145466
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043596	nuclear replication fork	IDA	J:141548
Cellular Component	GO:0005634	nucleus	IDA	J:173423
Cellular Component	GO:0005634	nucleus	IDA	J:141548
Cellular Component	GO:0008250	oligosaccharyltransferase complex	IDA	J:233654
Cellular Component	GO:0032993	protein-DNA complex	IDA	J:220965
Biological Process	GO:0002253	activation of immune response	IMP	J:141548
Biological Process	GO:0002250	adaptive immune response	IMP	J:220965
Biological Process	GO:0043277	apoptotic cell clearance	IMP	J:207137
Biological Process	GO:0003228	atrial cardiac muscle tissue development	IMP	J:92264
Biological Process	GO:0001568	blood vessel development	IMP	J:220965
Biological Process	GO:0035781	CD86 biosynthetic process	IMP	J:207137
Biological Process	GO:0071480	cellular response to gamma radiation	IMP	J:141548
Biological Process	GO:0072711	cellular response to hydroxyurea	IMP	J:141548
Biological Process	GO:0035458	cellular response to interferon-beta	IDA	J:145965
Biological Process	GO:0071310	cellular response to organic substance	IMP	J:243357
Biological Process	GO:0034599	cellular response to oxidative stress	IMP	J:208222
Biological Process	GO:0034614	cellular response to reactive oxygen species	IMP	J:208222
Biological Process	GO:0071357	cellular response to type I interferon	IMP	J:251493
Biological Process	GO:0034644	cellular response to UV	IDA	J:173423
Biological Process	GO:0051607	defense response to virus	IMP	J:191073
Biological Process	GO:0051607	defense response to virus	IMP	J:166550
Biological Process	GO:0008340	determination of adult lifespan	IGI	J:239522
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:92264
Biological Process	GO:0008340	determination of adult lifespan	IGI	J:226998
Biological Process	GO:0006308	DNA catabolic process	IBA	J:265628
Biological Process	GO:0006308	DNA catabolic process	IMP	J:155554
Biological Process	GO:0006308	DNA catabolic process	IMP	J:220965
Biological Process	GO:0006308	DNA catabolic process	IDA	J:166550
Biological Process	GO:0006308	DNA catabolic process	IMP	J:145466
Biological Process	GO:0006308	DNA catabolic process	IMP	J:208222
Biological Process	GO:0000077	DNA damage checkpoint signaling	IMP	J:141548
Biological Process	GO:0006974	DNA damage response	IDA	J:173423
Biological Process	GO:0032508	DNA duplex unwinding	IDA	J:220965
Biological Process	GO:0006259	DNA metabolic process	IDA	J:197521
Biological Process	GO:0006304	DNA modification	IMP	J:209222
Biological Process	GO:0006260	DNA replication	IMP	J:173423
Biological Process	GO:1904161	DNA synthesis involved in UV-damage excision repair	IMP	J:208222
Biological Process	GO:0045184	establishment of protein localization	IMP	J:191073
Biological Process	GO:0051319	G2 phase	IMP	J:141548
Biological Process	GO:0006091	generation of precursor metabolites and energy	IMP	J:239522
Biological Process	GO:0003007	heart morphogenesis	IMP	J:92264
Biological Process	GO:0003015	heart process	IMP	J:92264
Biological Process	GO:0097281	immune complex formation	IMP	J:220965
Biological Process	GO:0006955	immune response	IMP	J:251493
Biological Process	GO:0002383	immune response in brain or nervous system	IMP	J:207137
Biological Process	GO:0002381	immunoglobulin production involved in immunoglobulin-mediated immune response	IMP	J:220965
Biological Process	GO:0006954	inflammatory response	IMP	J:243357
Biological Process	GO:0006954	inflammatory response	IMP	J:220965
Biological Process	GO:0006954	inflammatory response	IMP	J:92264
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	IMP	J:207137
Biological Process	GO:0045087	innate immune response	IMP	J:191073
Biological Process	GO:0032607	interferon-alpha production	IMP	J:207137
Biological Process	GO:0001822	kidney development	IMP	J:220965
Biological Process	GO:0002320	lymphoid progenitor cell differentiation	IMP	J:220965
Biological Process	GO:0002281	macrophage activation involved in immune response	IMP	J:207137
Biological Process	GO:0031571	mitotic G1 DNA damage checkpoint signaling	IMP	J:141548
Biological Process	GO:0031571	mitotic G1 DNA damage checkpoint signaling	IMP	J:208222
Biological Process	GO:0045824	negative regulation of innate immune response	ISO	J:164563
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	IMP	J:145466
Biological Process	GO:0002251	organ or tissue specific immune response	IMP	J:207137
Biological Process	GO:0050821	protein stabilization	IDA	J:233654
Biological Process	GO:0050790	regulation of catalytic activity	IMP	J:191073
Biological Process	GO:0031323	regulation of cellular metabolic process	IGI	J:239522
Biological Process	GO:0031323	regulation of cellular metabolic process	IMP	J:239522
Biological Process	GO:0031323	regulation of cellular metabolic process	IGI	J:239522
Biological Process	GO:0043457	regulation of cellular respiration	IMP	J:239522
Biological Process	GO:0019217	regulation of fatty acid metabolic process	IMP	J:239522
Biological Process	GO:0010468	regulation of gene expression	IGI	J:191073
Biological Process	GO:0010468	regulation of gene expression	IGI	J:191073
Biological Process	GO:0010468	regulation of gene expression	IMP	J:191073
Biological Process	GO:0010468	regulation of gene expression	IGI	J:191073
Biological Process	GO:0010468	regulation of gene expression	IGI	J:191073
Biological Process	GO:0006110	regulation of glycolytic process	IMP	J:239522
Biological Process	GO:0002637	regulation of immunoglobulin production	IMP	J:233654
Biological Process	GO:0002637	regulation of immunoglobulin production	IGI	J:226998
Biological Process	GO:0050727	regulation of inflammatory response	IGI	J:239522
Biological Process	GO:0050727	regulation of inflammatory response	IGI	J:239522
Biological Process	GO:0045088	regulation of innate immune response	IMP	J:233654
Biological Process	GO:0045088	regulation of innate immune response	IMP	J:166550
Biological Process	GO:0046890	regulation of lipid biosynthetic process	IGI	J:239522
Biological Process	GO:1905671	regulation of lysosome organization	IMP	J:191073
Biological Process	GO:0061635	regulation of protein complex stability	IMP	J:233654
Biological Process	GO:0050863	regulation of T cell activation	IGI	J:226998
Biological Process	GO:0032680	regulation of tumor necrosis factor production	IMP	J:207137
Biological Process	GO:0032479	regulation of type I interferon production	IGI	J:226998
Biological Process	GO:0032479	regulation of type I interferon production	IMP	J:166550
Biological Process	GO:0032479	regulation of type I interferon production	IMP	J:202906
Biological Process	GO:0009411	response to UV	IMP	J:243357
Biological Process	GO:0032197	retrotransposition	IMP	J:251493
Biological Process	GO:0002457	T cell antigen processing and presentation	IMP	J:207137
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	IMP	J:243357

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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