GO Annotations Graph

• Symbol: Tyrobp
• Name: TYRO protein tyrosine kinase binding protein
• ID: MGI:1277211

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0019209	kinase activator activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:73938
Molecular Function	GO:0005515	protein binding	IPI	J:49203
Molecular Function	GO:0005515	protein binding	IPI	J:147155
Molecular Function	GO:0005515	protein binding	IPI	J:116120
Molecular Function	GO:0005515	protein binding	IPI	J:219772
Molecular Function	GO:0005515	protein binding	IPI	J:144335
Molecular Function	GO:0005515	protein binding	IPI	J:84951
Molecular Function	GO:0005515	protein binding	IPI	J:197348
Molecular Function	GO:0005515	protein binding	IPI	J:193006
Molecular Function	GO:0005515	protein binding	IPI	J:219772
Molecular Function	GO:0005515	protein binding	IPI	J:124243
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:260524
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:49203
Cellular Component	GO:0009986	cell surface	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2326808
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2395436
Biological Process	GO:0030036	actin cytoskeleton organization	IMP	J:139490
Biological Process	GO:0043277	apoptotic cell clearance	IMP	J:96626
Biological Process	GO:0097190	apoptotic signaling pathway	IDA	J:140167
Biological Process	GO:0030900	forebrain development	IDA	J:140167
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0007229	integrin-mediated signaling pathway	IMP	J:116120
Biological Process	GO:0002281	macrophage activation involved in immune response	IMP	J:116120
Biological Process	GO:0002282	microglial cell activation involved in immune response	IMP	J:221150
Biological Process	GO:0002282	microglial cell activation involved in immune response	IMP	J:221150
Biological Process	GO:0002282	microglial cell activation involved in immune response	IBA	J:265628
Biological Process	GO:0002274	myeloid leukocyte activation	ISO	J:164563
Biological Process	GO:0030889	negative regulation of B cell proliferation	ISO	J:164563
Biological Process	GO:0030889	negative regulation of B cell proliferation	IMP	J:177613
Biological Process	GO:0030889	negative regulation of B cell proliferation	IBA	J:265628
Biological Process	GO:0032693	negative regulation of interleukin-10 production	IMP	J:221150
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	IMP	J:96801
Biological Process	GO:0032911	negative regulation of transforming growth factor beta1 production	IMP	J:221150
Biological Process	GO:0032911	negative regulation of transforming growth factor beta1 production	IBA	J:265628
Biological Process	GO:0032480	negative regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0002283	neutrophil activation involved in immune response	IMP	J:116120
Biological Process	GO:0002283	neutrophil activation involved in immune response	IBA	J:265628
Biological Process	GO:0030316	osteoclast differentiation	IGI	J:178250
Biological Process	GO:0030316	osteoclast differentiation	ISO	J:178250
Biological Process	GO:0030316	osteoclast differentiation	IDA	J:178250
Biological Process	GO:0030316	osteoclast differentiation	IMP	J:178250
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:221150
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:221150
Biological Process	GO:0110090	positive regulation of hippocampal neuron apoptotic process	IDA	J:140167
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IMP	J:221150
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:221150
Biological Process	GO:0034241	positive regulation of macrophage fusion	ISO	J:164563
Biological Process	GO:0034241	positive regulation of macrophage fusion	IMP	J:258167
Biological Process	GO:0034241	positive regulation of macrophage fusion	IBA	J:265628
Biological Process	GO:1904151	positive regulation of microglial cell mediated cytotoxicity	IMP	J:140167
Biological Process	GO:1904151	positive regulation of microglial cell mediated cytotoxicity	IBA	J:265628
Biological Process	GO:0032816	positive regulation of natural killer cell activation	IDA	J:49203
Biological Process	GO:0032816	positive regulation of natural killer cell activation	IBA	J:265628
Biological Process	GO:1901216	positive regulation of neuron death	IMP	J:221150
Biological Process	GO:2001206	positive regulation of osteoclast development	IMP	J:111212
Biological Process	GO:2000010	positive regulation of protein localization to cell surface	ISO	J:164563
Biological Process	GO:1902685	positive regulation of receptor localization to synapse	IMP	J:96801
Biological Process	GO:0032930	positive regulation of superoxide anion generation	IDA	J:140167
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:221150
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:2001204	regulation of osteoclast development	IGI	J:193006
Biological Process	GO:0048678	response to axon injury	IMP	J:221150
Biological Process	GO:0002223	stimulatory C-type lectin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0002222	stimulatory killer cell immunoglobulin-like receptor signaling pathway	ISO	J:164563