GO Annotations Graph

• Symbol: Pik3ca
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
• ID: MGI:1206581

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	ISO	J:155856
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	ISO	J:164563
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	IBA	J:265628
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	IMP	J:158739
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	IDA	J:125968
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	IMP	J:327397
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	IDA	J:87902
Molecular Function	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0043560	insulin receptor substrate binding	IPI	J:109204
Molecular Function	GO:0043560	insulin receptor substrate binding	IPI	J:109204
Molecular Function	GO:0016301	kinase activity	ISO	J:217701
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0035004	phosphatidylinositol 3-kinase activity	IEA	J:72247
Molecular Function	GO:0052812	phosphatidylinositol-3,4-bisphosphate 5-kinase activity	IEA	J:72245
Molecular Function	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IEA	J:72245
Molecular Function	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS	Reactome:R-NUL-9616944
Molecular Function	GO:0005515	protein binding	IPI	J:292538
Molecular Function	GO:0005515	protein binding	IPI	J:136236
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:122866
Molecular Function	GO:0005515	protein binding	IPI	J:239186
Molecular Function	GO:0005515	protein binding	IPI	J:36742
Molecular Function	GO:0030295	protein kinase activator activity	IDA	J:173141
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	IMP	J:158739
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	IDA	J:125968
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	IMP	J:327397
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:72245
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027268
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9031553
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680646
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682158
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682182
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9031077
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9603412
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9616944
Cellular Component	GO:0014704	intercalated disc	IDA	J:292538
Cellular Component	GO:0030027	lamellipodium	IDA	J:87902
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	ISO	J:155856
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	IPI	J:36742
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	ISO	J:164563
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	IBA	J:265628
Cellular Component	GO:0005944	phosphatidylinositol 3-kinase complex, class IB	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0030036	actin cytoskeleton organization	IMP	J:292538
Biological Process	GO:0060612	adipose tissue development	IMP	J:213164
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0086003	cardiac muscle cell contraction	IMP	J:292538
Biological Process	GO:0016477	cell migration	IBA	J:265628
Biological Process	GO:0071333	cellular response to glucose stimulus	IMP	J:213164
Biological Process	GO:0071464	cellular response to hydrostatic pressure	IMP	J:292538
Biological Process	GO:0097009	energy homeostasis	IMP	J:213164
Biological Process	GO:0006006	glucose metabolic process	IMP	J:109024
Biological Process	GO:0008286	insulin receptor signaling pathway	IMP	J:158739
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IDA	J:125968
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IMP	J:327397
Biological Process	GO:0001889	liver development	IMP	J:213164
Biological Process	GO:0030835	negative regulation of actin filament depolymerization	IMP	J:292538
Biological Process	GO:2000811	negative regulation of anoikis	ISO	J:164563
Biological Process	GO:2000270	negative regulation of fibroblast apoptotic process	IDA	J:91529
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:84857
Biological Process	GO:0006909	phagocytosis	IEA	J:60000
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IMP	J:292538
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IBA	J:265628
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	ISO	J:155856
Biological Process	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	IBA	J:265628
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	IEA	J:72247
Biological Process	GO:0016310	phosphorylation	ISO	J:217701
Biological Process	GO:0044029	positive regulation of gene expression via CpG island demethylation	IDA	J:173141
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IDA	J:173141
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:285299
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:109024
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:109024
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:109024
Biological Process	GO:0110053	regulation of actin filament organization	IMP	J:292538
Biological Process	GO:0043457	regulation of cellular respiration	IMP	J:213164
Biological Process	GO:0010468	regulation of gene expression	IMP	J:146128
Biological Process	GO:2000653	regulation of genetic imprinting	IDA	J:173141
Biological Process	GO:0040014	regulation of multicellular organism growth	IMP	J:109024
Biological Process	GO:0001932	regulation of protein phosphorylation	IDA	J:91529
Biological Process	GO:0055119	relaxation of cardiac muscle	IMP	J:292538
Biological Process	GO:0035994	response to muscle stretch	IMP	J:292538
Biological Process	GO:0038203	TORC2 signaling	ISO	J:285299
Biological Process	GO:0038084	vascular endothelial growth factor signaling pathway	ISO	J:164563