GO Annotations Graph

• Symbol: Sh2b1
• Name: SH2B adaptor protein 1
• ID: MGI:1201407

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:172913
Molecular Function	GO:0005515	protein binding	IPI	J:200437
Molecular Function	GO:0005515	protein binding	IPI	J:200316
Molecular Function	GO:0035591	signaling adaptor activity	IEA	J:72247
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2671830
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2671841
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2671852
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0001726	ruffle	TAS	J:75465
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0030032	lamellipodium assembly	IDA	J:75465
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	IDA	J:172913
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	ISO	J:242251
Biological Process	GO:2000278	regulation of DNA biosynthetic process	IMP	J:172913
Biological Process	GO:0007165	signal transduction	IEA	J:72247