Alox8 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Alox8
arachidonate 8-lipoxygenase
MGI:1098228

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Wed Mar 2 12:11:24 2016.

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0018559	1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0034827	1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018557	1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018566	1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018561	2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018556	2,2',3-trihydroxybiphenyl dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018542	2,3-dihydroxy DDT 1,2-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018563	2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018571	2,3-dihydroxy-p-cumate dioxygenase activity	IEA	J:72245
Molecular Function	GO:0034955	2,3-dihydroxydiphenyl ether dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018574	2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018573	2-aminophenol 1,6-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0034834	2-mercaptobenzothiazole dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018562	3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018568	3,4-dihydroxyphenanthrene dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018572	3,5-dichlorocatechol 1,2-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0034803	3-hydroxy-2-naphthoate 2,3-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0034810	4,5-dihydroxybenzo(a)pyrene dioxygenase activity	IEA	J:72245
Molecular Function	GO:0034922	4,5-dihydroxypyrene dioxygenase activity	IEA	J:72245
Molecular Function	GO:0034936	4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0047074	4-hydroxycatechol 1,2-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018558	5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity	IEA	J:72245
Molecular Function	GO:0034543	5-aminosalicylate dioxygenase activity	IEA	J:72245
Molecular Function	GO:0034814	7,8-dihydroxy benzo(a)pyrene dioxygenase activity	IEA	J:72245
Molecular Function	GO:0034812	9,10-dihydroxybenzo(a)pyrene dioxygenase activity	IEA	J:72245
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ISO	J:164563
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ISO	J:155856
Molecular Function	GO:0047677	arachidonate 8(R)-lipoxygenase activity	IEA	J:72245
Molecular Function	GO:0036403	arachidonate 8(S)-lipoxygenase activity	IDA	J:200515
Molecular Function	GO:0034806	benzo(a)pyrene 11,12-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0034808	benzo(a)pyrene 4,5-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0034813	benzo(a)pyrene 7,8-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0034811	benzo(a)pyrene 9,10-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0018564	carbazole 1,9a-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0019114	catechol dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018575	chlorocatechol 1,2-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018565	dihydroxydibenzothiophene dioxygenase activity	IEA	J:72245
Molecular Function	GO:0019117	dihydroxyfluorene dioxygenase activity	IEA	J:72245
Molecular Function	GO:0051213	dioxygenase activity	IEA	J:60000
Molecular Function	GO:0034956	diphenyl ether 1,2-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018569	hydroquinone 1,2-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0005506	iron ion binding	ISO	J:164563
Molecular Function	GO:0016165	linoleate 13S-lipoxygenase activity	ISO	J:164563
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	J:72247
Molecular Function	GO:0018570	p-cumate 2,3-dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018555	phenanthrene dioxygenase activity	IEA	J:72245
Molecular Function	GO:0034934	phenanthrene-4-carboxylate dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018560	protocatechuate 3,4-dioxygenase type II activity	IEA	J:72245
Molecular Function	GO:0034920	pyrene dioxygenase activity	IEA	J:72245
Molecular Function	GO:0034895	pyridine-3,4-diol dioxygenase activity	IEA	J:72245
Molecular Function	GO:0018567	styrene dioxygenase activity	IEA	J:72245
Molecular Function	GO:0034935	tetrachlorobenzene dioxygenase activity	IEA	J:72245
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0019898	extrinsic component of membrane	ISO	J:164563
Cellular Component	GO:0005622	intracellular	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0019369	arachidonic acid metabolic process	IDA	J:43206
Biological Process	GO:0019369	arachidonic acid metabolic process	ISO	J:164563
Biological Process	GO:0019369	arachidonic acid metabolic process	ISO	J:155856
Biological Process	GO:0051122	hepoxilin biosynthetic process	ISO	J:155856
Biological Process	GO:0043651	linoleic acid metabolic process	IDA	J:43206
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0019372	lipoxygenase pathway	ISO	J:155856
Biological Process	GO:0019372	lipoxygenase pathway	IDA	J:43206
Biological Process	GO:0045786	negative regulation of cell cycle	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell proliferation	ISO	J:164563
Biological Process	GO:0045926	negative regulation of growth	ISO	J:164563
Biological Process	GO:0055114	oxidation-reduction process	IEA	J:60000
Biological Process	GO:0055114	oxidation-reduction process	IEA	J:72247
Biological Process	GO:0090197	positive regulation of chemokine secretion	ISO	J:164563
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation	IMP	J:133831
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	ISO	J:164563
Biological Process	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway	IMP	J:133831

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 03/02/2021 MGI 6.16