GO Annotations Graph

• Symbol: Cx3cl1
• Name: C-X3-C motif chemokine ligand 1
• ID: MGI:1097153

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048020	CCR chemokine receptor binding	IBA	J:265628
Molecular Function	GO:0042056	chemoattractant activity	ISO	J:164563
Molecular Function	GO:0008009	chemokine activity	ISO	J:155856
Molecular Function	GO:0008009	chemokine activity	ISO	J:164563
Molecular Function	GO:0008009	chemokine activity	IBA	J:265628
Molecular Function	GO:0031737	CX3C chemokine receptor binding	IDA	J:145036
Molecular Function	GO:0031737	CX3C chemokine receptor binding	ISO	J:164563
Molecular Function	GO:0045237	CXCR1 chemokine receptor binding	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Cellular Component	GO:0044297	cell body	IDA	J:263392
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	IDA	J:263392
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	IDA	J:263392
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:267237
Biological Process	GO:0060055	angiogenesis involved in wound healing	IMP	J:130909
Biological Process	GO:0035425	autocrine signaling	ISO	J:155856
Biological Process	GO:0007155	cell adhesion	ISO	J:164563
Biological Process	GO:0060326	cell chemotaxis	ISO	J:164563
Biological Process	GO:0098609	cell-cell adhesion	ISO	J:155856
Biological Process	GO:0071347	cellular response to interleukin-1	IBA	J:265628
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IBA	J:265628
Biological Process	GO:0071346	cellular response to type II interferon	IBA	J:265628
Biological Process	GO:0070098	chemokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070098	chemokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0006935	chemotaxis	ISO	J:155856
Biological Process	GO:0006935	chemotaxis	ISO	J:164563
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IMP	J:145036
Biological Process	GO:0048245	eosinophil chemotaxis	IBA	J:265628
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IDA	J:145036
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IDA	J:132951
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0060080	inhibitory postsynaptic potential	ISO	J:155856
Biological Process	GO:0033622	integrin activation	ISO	J:164563
Biological Process	GO:0050902	leukocyte adhesive activation	IEA	J:72247
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	ISO	J:164563
Biological Process	GO:0048247	lymphocyte chemotaxis	IBA	J:265628
Biological Process	GO:0048247	lymphocyte chemotaxis	IDA	J:40832
Biological Process	GO:0001774	microglial cell activation	ISO	J:155856
Biological Process	GO:0061518	microglial cell proliferation	ISO	J:164563
Biological Process	GO:0002548	monocyte chemotaxis	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA	J:145036
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA	J:132951
Biological Process	GO:1900450	negative regulation of glutamate receptor signaling pathway	ISO	J:155856
Biological Process	GO:0110091	negative regulation of hippocampal neuron apoptotic process	ISO	J:164563
Biological Process	GO:0032690	negative regulation of interleukin-1 alpha production	ISO	J:155856
Biological Process	GO:1903979	negative regulation of microglial cell activation	ISO	J:155856
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0045906	negative regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0070050	neuron cellular homeostasis	ISO	J:155856
Biological Process	GO:0030593	neutrophil chemotaxis	IBA	J:265628
Biological Process	GO:0030593	neutrophil chemotaxis	IDA	J:40832
Biological Process	GO:0030168	platelet activation	ISO	J:155856
Biological Process	GO:0050918	positive chemotaxis	ISO	J:164563
Biological Process	GO:0032233	positive regulation of actin filament bundle assembly	ISO	J:164563
Biological Process	GO:0051041	positive regulation of calcium-independent cell-cell adhesion	ISO	J:164563
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:155856
Biological Process	GO:1903721	positive regulation of I-kappaB phosphorylation	ISO	J:164563
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:1904141	positive regulation of microglial cell migration	ISO	J:164563
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	ISO	J:155856
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:155856
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0032914	positive regulation of transforming growth factor beta1 production	IMP	J:130909
Biological Process	GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0002931	response to ischemia	ISO	J:155856
Biological Process	GO:0042060	wound healing	IMP	J:130909